Name: | ketazolam |
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PubChem Compound ID: | 33746 |
Molecular formula: | C20H17ClN2O3 |
Molecular weight: | 368.813 g/mol |
Synonyms: |
DEA No. 2772; U 28774; 4H-(1,3)Oxazino(3,2-d)(1,4)benzodiazepine-4,7(6H)-dione, 8,12b-dihydro-11-chloro-2,8-dimethyl-12b-phenyl-; 11-Chloro-8,12b-dihydro-2,8-dimethyl-12b-phenyl-4H-(1,3)oxazino(3,2-d)(1,4)benzodiazepine-4,7(6H)-dione; NSC 338158; Anxon; 4H-(1,3)Oxazino(3,2-d)(1,4)benzodiazepine-4,7(6H)-dione, 11-chloro-8,12b-dihydro-2,8-dimethyl-12b-phenyl- (8CI)(9CI); 4H-(1,3)-Oxazino(3,2-d)(1,4)benzodiazepine-4,7(6H)-dione, 11-chloro-8,12b-dihydro-2,8-dimethyl-; EINECS 248-346-3; Ketazolam [USAN:BAN:INN].
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Name: | ketazolam |
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Name (isomeric): | DB01587 |
Drug Type: | small molecule |
Category: | Benzodiazepines, Anti-anxiety Agents |
CAS number: | 27223-35-4 |
Indication: | Ketazolam could be used for the treatment of anxiety. In approved countries, it is indicated for the treatment of anxiety, tension, irritability and similar stress related symptoms. |
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Pharmacology: |
Benzodiazepines enhance the effect of the neurotransmitter gamma-aminobutyric acid (GABA), which results in sedative, hypnotic, anxiolytic, anticonvulsant, muscle relaxant and amnesic action.
Benzodiazepines bind nonspecifically to benzodiazepine receptors which mediate sleep, affects muscle relaxation, anticonvulsant activity, motor coordination, ...
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Mechanism of Action: |
Benzodiazepines share a similar chemical structure and their effects in humans are mainly produced by the allosteric modification of a specific kind of neurotransmitter receptor, the GABAA receptor, which increases the conductance of this inhibitory channel; this results in the various therapeutic effects as well as adverse effects of benzodiazepin...
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Biotransformation: | Ketazolam breaks down in the blood to diazepam which breaks down to demoxepam which breaks down to desmethyldiazepam. |
Route of elimination: | Diazepam and its metabolites are excreted mainly in the urine, predominantly as their glucuronide conjugates. |
Half Life: | 26-200 hours |
Toxicity: | Symptoms of overdose include somnolence, confusion, coma, and diminished reflexes. Respiration, pulse and blood pressure should be monitored. |
Food interaction: |
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Drug interaction: |
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