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QuickView for Ketazolam (compound)

Name: ketazolam
PubChem Compound ID: 33746
Molecular formula: C20H17ClN2O3
Molecular weight: 368.813 g/mol
DEA No. 2772; U 28774; 4H-(1,3)Oxazino(3,2-d)(1,4)benzodiazepine-4,7(6H)-dione, 8,12b-dihydro-11-chloro-2,8-dimethyl-12b-phenyl-; 11-Chloro-8,12b-dihydro-2,8-dimethyl-12b-phenyl-4H-(1,3)oxazino(3,2-d)(1,4)benzodiazepine-4,7(6H)-dione; NSC 338158; Anxon; 4H-(1,3)Oxazino(3,2-d)(1,4)benzodiazepine-4,7(6H)-dione, 11-chloro-8,12b-dihydro-2,8-dimethyl-12b-phenyl- (8CI)(9CI); 4H-(1,3)-Oxazino(3,2-d)(1,4)benzodiazepine-4,7(6H)-dione, 11-chloro-8,12b-dihydro-2,8-dimethyl-; EINECS 248-346-3; Ketazolam [USAN:BAN:INN].
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Name: ketazolam
Name (isomeric): DB01587
Drug Type: small molecule
Category: Benzodiazepines, Anti-anxiety Agents
CAS number: 27223-35-4
Indication: Ketazolam could be used for the treatment of anxiety. In approved countries, it is indicated for the treatment of anxiety, tension, irritability and similar stress related symptoms.
Benzodiazepines enhance the effect of the neurotransmitter gamma-aminobutyric acid (GABA), which results in sedative, hypnotic, anxiolytic, anticonvulsant, muscle relaxant and amnesic action. Benzodiazepines bind nonspecifically to benzodiazepine receptors which mediate sleep, affects muscle relaxation, anticonvulsant activity, motor coordination, ...
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Mechanism of Action:
Benzodiazepines share a similar chemical structure and their effects in humans are mainly produced by the allosteric modification of a specific kind of neurotransmitter receptor, the GABAA receptor, which increases the conductance of this inhibitory channel; this results in the various therapeutic effects as well as adverse effects of benzodiazepin...
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Biotransformation: Ketazolam breaks down in the blood to diazepam which breaks down to demoxepam which breaks down to desmethyldiazepam.
Route of elimination: Diazepam and its metabolites are excreted mainly in the urine, predominantly as their glucuronide conjugates.
Half Life: 26-200 hours
Toxicity: Symptoms of overdose include somnolence, confusion, coma, and diminished reflexes. Respiration, pulse and blood pressure should be monitored.
Food interaction:
Avoid excessive quantities of coffee or tea (caffeine).
Avoid taking with grapefruit or grapefruit juice as grapefruit can significantly increase serum levels of this product.
Avoid alcohol
Take with food.
Drug interaction:
CimetidineCimetidine may increase the effect of the benzodiazepine, ketazolam.
OmeprazoleOmeprazole may increase the effect of the benzodiazepine, ketazolam.
ClozapineIncreased risk of toxicity