QuickView for MSH3;jsessionid=59BC7DB9F2875615DA16615EB49CE25E (gene)
- Gene Symbol:
- MSH3
Homo sapiens - Full name:
- mutS homolog 3
- Synonyms:
- DUP, FAP4, MRP1, DNA mismatch repair protein Msh3, divergent upstream protein, hMSH3, mismatch repair protein 1
- Genomic Location:
- Chr 5: 79986050-80208390
- Description:
-
The protein encoded by this gene forms a heterodimer with MSH2 to form MutS beta, part of the post-replicative DNA mismatch repair system. MutS beta initiates mismatch repair by binding to a mismatch and then forming a complex with MutL alpha heterodimer. This gene contains a polymorphic 9 bp tandem repeat sequence in the first exon. The repeat is ...
- Orthologs:
- Mus musculus , Rattus norvegicus , Saccharomyces cerevisiae , Macaca mulatta , Schizosaccharomyces pombe , Canis lupus familiaris , Danio rerio , Bos taurus , Pan troglodytes , Gallus gallus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- Cytogenetic Map:
-
5q14.1
GO Molecular Function
sequence-specific DNA binding | heteroduplex DNA loop binding | dinucleotide insertion or deletion binding | single base insertion or deletion binding | DNA secondary structure binding | enzyme binding | nucleic acid binding | ribonucleotide binding | nucleotide binding | hydrolase activity | single-stranded DNA binding | mismatched DNA binding | Y-form DNA binding | carbohydrate derivative binding | ATPase activity | pyrophosphatase activity | dinucleotide repeat insertion binding | catalytic activity | ATP binding | anion binding | DNA insertion or deletion binding | adenyl nucleotide binding | nucleoside-triphosphatase activity | ATPase activity, coupled | DNA binding | sequence-specific double-stranded DNA binding | purine nucleotide binding | identical protein binding | damaged DNA binding | ion binding | organic cyclic compound binding | guanine/thymine mispair binding | purine ribonucleoside triphosphate binding | protein binding | protein homodimerization activity | double-stranded DNA binding | double-strand/single-strand DNA junction binding | protein dimerization activity | oxidized purine DNA binding | hydrolase activity, acting on acid anhydrides | single guanine insertion binding | single thymine insertion binding | purine ribonucleotide binding | adenyl ribonucleotide binding | DNA-dependent ATPase activity | drug binding | oxidized DNA binding | centromeric DNA binding | heterocyclic compound binding | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | small molecule binding
GO Biological Process
negative regulation of cellular process | regulation of DNA replication | negative regulation of DNA metabolic process | cellular process | DNA-dependent DNA replication maintenance of fidelity | positive regulation of catalytic activity | negative regulation of cellular metabolic process | regulation of cellular process | regulation of metabolic process | organic cyclic compound metabolic process | cellular aromatic compound metabolic process | DNA-dependent DNA replication | cellular component organization | negative regulation of DNA replication | response to stimulus | regulation of DNA recombination | response to stress | reproduction | cellular nitrogen compound metabolic process | negative regulation of metabolic process | cellular biosynthetic process | DNA recombination | DNA repair | nitrogen compound metabolic process | reproductive process | cellular response to DNA damage stimulus | regulation of catalytic activity | cellular response to stress | cell cycle | regulation of nitrogen compound metabolic process | positive regulation of hydrolase activity | biosynthetic process | mismatch repair | regulation of DNA-dependent DNA replication | maintenance of DNA repeat elements | regulation of cellular metabolic process | positive regulation of helicase activity | positive regulation of molecular function | negative regulation of DNA-dependent DNA replication | DNA metabolic process | reciprocal meiotic recombination | nuclear division | metabolic process | nucleobase-containing compound metabolic process | organic substance metabolic process | negative regulation of biosynthetic process | mitotic recombination | meiosis I | negative regulation of DNA recombination | meiotic cell cycle | replication fork arrest | meiotic mismatch repair | cellular macromolecule biosynthetic process | homologous recombination | organelle organization | heterocycle metabolic process | chromosome organization | cellular metabolic process | DNA replication | removal of nonhomologous ends | macromolecule metabolic process
GO Cellular Component
intracellular membrane-bounded organelle | DNA repair complex | cell | nuclear lumen | intracellular organelle | protein-containing complex | nucleoplasm | membrane-bounded organelle | nucleus | organelle | MutSbeta complex | membrane-enclosed lumen | mismatch repair complex | intracellular | membrane
