Import Your Data

FAQ

More QuickView FAQs

QuickView

0
Meta-
Analysis

Bookmark Forward

QuickView for Methantheline (compound)

Summary
General Info

PubChem

PubChem Compound 4097

PubChem Compound 4097

Name:	methantheline
PubChem Compound ID:	4097
Molecular formula:	C₂₁H₂₆NO₃⁺
Molecular weight:	340.436 g/mol
Synonyms:	Ammonium, diethyl (2-hydroxyethyl)methyl-, bromide, xanthene-9-carboxylate; MTB 51; nchembio747-comp13; Metaxan; Methantheline bromide; .beta.-Diethylaminoethyl 9-xanthenecarboxylate methobromide; Banthine; Methanthelinium; Methelina; SPBio_002966. show more » Ammonium, diethyl (2-hydroxyethyl)methyl-, bromide, xanthene-9-carboxylate; MTB 51; nchembio747-comp13; Metaxan; Methantheline bromide; .beta.-Diethylaminoethyl 9-xanthenecarboxylate methobromide; Banthine; Methanthelinium; Methelina; SPBio_002966; .beta.-Diethylaminoethyl xanthene-9-carboxylate methobromide; Xanteline; CAS-53-46-3; Dixamone bromide; Frenogastrico; Ethanaminium, N,N-diethyl-N-methyl-2-[ (9H-xanthen-9-ylcarbonyl)oxy]-, bromide; Gastrosedan; Ethanaminium, N,N-diethyl-N-methyl-2-((9H-xanthen-9-ylcarbonyl)oxy)-; Methantheline; Resobantin; Prestwick1_001066; C07849; Diethyl(2-hydroxyethyl)methylammoniumbromide xanthene-9-carboxylate; SC 2910; Asabaine; Methanthelinum; Prestwick0_001066; NCGC00016239-01; N,N-Diethyl-N-methyl-2-[(9H-xanthen-9-ylcarbonyl)oxy]ethanaminium; Banthine bromide; Ulcudexter; Doladene; 5818-17-7; Banthin; NSC32145; Methanthelinium bromide; Methanide; Avagal; Methanthine bromide; Metantyl; 53-46-3; Xanthene-9-carboxylic acid, ester with diethyl(2-hydroxyethyl)methylammonium bromide; Mantheline; Ulcine; Vagamin; Gastron; Vagantin show less «

DrugBank

Identification

Name:	methantheline
Name (isomeric):	DB00940
Drug Type:	small molecule
Synonyms:	Banthine Bromide; Methanthelinium; MTB 51; Methantheline Bromide; Methanthelinum; Methanthelinium Bromide; Methanthine Bromide
Brand:	Vagamin, Resobantin, Methanide, Gastron, Avagal, Dixamone Bromide, Methelina, Doladene, Mantheline, Vagantin, Ulcine, Xanteline, Banthine, Gastrin I, Frenogastrico, Gastrin-1 Human, Metaxan, Metantyl, Banthin, Asabaine, Gastrosedan, Ulcudexter
Category:	Anticholinergic Agents, Antispasmodics
CAS number:	5818-17-7

Pharmacology

Indication:	For the treatment of peptic ulcer disease, irritable bowel syndrome, pancreatitis, gastritis, biliary dyskinesia, pylorosplasm, and reflex neurogenic bladder in children.
Pharmacology:	Methantheline is a synthetic quarternary ammonium antimuscarinic used to relieve cramps or spasms of the stomach, intestines, and bladder. It can be used together with antacids or other medicines, such as H2-receptor antagonists, in the treatment of peptic ulcer. Methantheline inhibits muscarinic actions at postganglionic parasympathetic neuroeffec... show more » Methantheline is a synthetic quarternary ammonium antimuscarinic used to relieve cramps or spasms of the stomach, intestines, and bladder. It can be used together with antacids or other medicines, such as H2-receptor antagonists, in the treatment of peptic ulcer. Methantheline inhibits muscarinic actions at postganglionic parasympathetic neuroeffector sites. show less «
Mechanism of Action:	Methantheline inhibits the muscarinic actions of acetylcholine on structures innervated by postganglionic cholinergic nerves as well as on smooth muscles that respond to acetylcholine but lack cholinergic innervation. These postganglionic receptor sites are present in the autonomic effector cells of the smooth muscle, cardiac muscle, sinoatrial and... show more » Methantheline inhibits the muscarinic actions of acetylcholine on structures innervated by postganglionic cholinergic nerves as well as on smooth muscles that respond to acetylcholine but lack cholinergic innervation. These postganglionic receptor sites are present in the autonomic effector cells of the smooth muscle, cardiac muscle, sinoatrial and atrioventricular nodes, and exocrine glands. Depending on the dose, anticholinergics may reduce the motility and secretory activity of the gastrointestinal system, and the tone of the ureter and urinary bladder and may have a slight relaxant action on the bile ducts and gallbladder. show less «
Absorption:	Rapidly absorbed.
Biotransformation:	Hepatic, by enzymatic hydrolysis.
Toxicity:	Symptoms of overdose: blurred vision (continuing) or changes in near vision, clumsiness or unsteadiness, confusion, convulsions, difficulty in breathing, muscle weakness (severe), or tiredness (severe), dizziness, drowsiness (severe), dryness of mouth, nose, or throat (severe), fast heartbeat, fever, hallucinations, slurred speech, unusual excitement, nervousness, restlessness, or irritability, unusual warmth, dryness, and flushing of skin.
Affected organisms:	Humans and other mammals

Interactions

Drug interaction:

Triprolidine	Triprolidine and Methantheline, two anticholinergics, may cause additive anticholinergic effects and enhance their adverse/toxic effects. Monitor for enhanced anticholinergic effects.
Tacrine	The therapeutic effects of the central acetylcholinesterase inhibitor, Tacrine, and/or the anticholinergic, Methantheline, may be reduced due to antagonism. The interaction may be beneficial when the anticholinergic action is a side effect. Monitor for decreased efficacy of both agents.
Haloperidol	The anticholinergic increases the risk of psychosis and tardive dyskinesia
Trospium	Trospium and Methantheline, two anticholinergics, may cause additive anticholinergic effects and enhanced adverse/toxic effects. Monitor for enhanced anticholinergic effects.
Trimethobenzamide	Trimethobenzamide and Methantheline, two anticholinergics, may cause additive anticholinergic effects and enhance their adverse/toxic effects. Monitor for enhanced anticholinergic effects.

Targets

Muscarinic acetylcholine receptor M1

Histamine H2 receptor