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QuickView for Oxacillin (compound)
PubChem
| Name: | Oxacillin |
|---|---|
| PubChem Compound ID: | 1548982 |
| Description: | An antibiotic similar to FLUCLOXACILLIN used in resistant staphylococci infections. |
| Molecular formula: | C19H18N3O5S- |
| Molecular weight: | 400.429 g/mol |
| Synonyms: |
ZINC01530747
|
DrugBank
Identification
| Name: | Oxacillin |
|---|---|
| Name (isomeric): | DB00713 |
| Drug Type: | small molecule |
| Description: | An antibiotic similar to FLUCLOXACILLIN used in resistant staphylococci infections. |
| Synonyms: |
Oxacillin Sodium
|
| Brand: | Bactocill |
| Category: | Anti-Bacterial Agents, Penicillins |
| CAS number: | 66-79-5 |
Pharmacology
| Indication: | Used in the treatment of resistant staphylococci infections. |
|---|---|
| Pharmacology: |
Oxacillin is a penicillin beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually gram-positive, organisms. The name "penicillin" can either refer to several variants of penicillin available, or to the group of antibiotics derived from the penicillins. Oxacillin has in vitro activity against gram-positive...
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| Mechanism of Action: | By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, Oxacillin inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that Oxacillin interferes with an autolysin inhibitor. |
| Protein binding: | 94.2 +/- 2.1% (binds to serum protein, mainly albumin) |
| Route of elimination: | Oxacillin Sodium is rapidly excreted as unchanged drug in the urine by glomerular filtration and active tubular secretion. |
| Half Life: | 20 to 30 minutes |
| Affected organisms: | Enteric bacteria and other eubacteria |
Interactions
| Drug interaction: |
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Targets
Transporters
