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QuickView for Oxacillin (compound)

Name: Oxacillin
PubChem Compound ID: 1548982
Description: An antibiotic similar to FLUCLOXACILLIN used in resistant staphylococci infections.
Molecular formula: C19H18N3O5S-
Molecular weight: 400.429 g/mol
Name: Oxacillin
Name (isomeric): DB00713
Drug Type: small molecule
Description: An antibiotic similar to FLUCLOXACILLIN used in resistant staphylococci infections.
Oxacillin Sodium
Brand: Bactocill
Category: Anti-Bacterial Agents, Penicillins
CAS number: 66-79-5
Indication: Used in the treatment of resistant staphylococci infections.
Oxacillin is a penicillin beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually gram-positive, organisms. The name "penicillin" can either refer to several variants of penicillin available, or to the group of antibiotics derived from the penicillins. Oxacillin has in vitro activity against gram-positive...
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Mechanism of Action: By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, Oxacillin inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that Oxacillin interferes with an autolysin inhibitor.
Protein binding: 94.2 +/- 2.1% (binds to serum protein, mainly albumin)
Route of elimination: Oxacillin Sodium is rapidly excreted as unchanged drug in the urine by glomerular filtration and active tubular secretion.
Half Life: 20 to 30 minutes
Affected organisms: Enteric bacteria and other eubacteria
Drug interaction:
Ethinyl EstradiolThis anti-infectious agent could decrease the effect of the oral contraceptive
DoxycyclinePossible antagonism of action
DemeclocyclinePossible antagonism of action
MinocyclinePossible antagonism of action
TetracyclinePossible antagonism of action