QuickView for PLAG1 (gene)

Gene Symbol:

PLAG1 Homo sapiens

Full name:

PLAG1 zinc finger

Synonyms:

PSA, SGPA, ZNF912, zinc finger protein PLAG1, COL1A2/PLAG1 fusion, HAS2/PLAG1 fusion, pleiomorphic adenoma gene 1

Genomic Location:

Chr 8: 57236037-57286392

Description:

Pleomorphic adenoma gene 1 encodes a zinc finger protein with 2 putative nuclear localization signals. PLAG1, which is developmentally regulated, has been shown to be consistently rearranged in pleomorphic adenomas of the salivary glands. PLAG1 is activated by the reciprocal chromosomal translocations involving 8q12 in a subset of salivary gland pl...

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Pleomorphic adenoma gene 1 encodes a zinc finger protein with 2 putative nuclear localization signals. PLAG1, which is developmentally regulated, has been shown to be consistently rearranged in pleomorphic adenomas of the salivary glands. PLAG1 is activated by the reciprocal chromosomal translocations involving 8q12 in a subset of salivary gland pleomorphic adenomas. Three transcript variants encoding two different isoforms have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  FOXO1_02 ,  POU6F1_01 ,  AACWWCAANK_UNKNOWN ,  RTAAACA_FREAC2_01 ,  HNF4ALPHA_Q6 ,  PAX4_04 ,  ATAAGCT_MIR21 ,  GTGCCAT_MIR183 ,  FREAC7_01 ,  HNF3ALPHA_Q6 ,  TFIIA_Q6 ,  AREB6_02 ,  FOX_Q2 ,  AAAGGGA_MIR204_MIR211 ,  TGAATGT_MIR181A_MIR181B_MIR181C_MIR181D ,  HFH3_01 ,  SREBP1_02 ,  AP3_Q6 ,  FOXO4_01 ,  PR_01 ,  GATA_Q6 ,  TTTTGAG_MIR373 ,  GATA_C ,  CACGTG_MYC_Q2 ,  CTACTGT_MIR199A ,  FOXD3_01 ,  AGCACTT_MIR93_MIR302A_MIR302B_MIR302C_MIR302D_MIR372_MIR373_MIR520E_MIR520A_MIR526B_MIR520B_MIR520C_MIR520D ,  CIZ_01 ,  LXR_DR4_Q3 ,  GTGACTT_MIR224 ,  EVI1_04 ,  CAGTGTT_MIR141_MIR200A ,  TGTTTAC_MIR30A5P_MIR30C_MIR30D_MIR30B_MIR30E5P ,  GATAAGR_GATA_C ,  CTTTGA_LEF1_Q2 ,  GATA1_04 ,  ACTGTGA_MIR27A_MIR27B ,  GGGAGGRR_MAZ_Q6 ,  AR_02 ,  TATAAA_TATA_01 ,  EVI1_03 ,  MYCMAX_02 ,  DBP_Q6 ,  FOXO3_01 ,  CDX2_Q5 ,  CAGGTG_E12_Q6 ,  CAGCTTT_MIR320 ,  YY1_01 ,  GR_Q6 ,  EVI1_02 ,  NKX62_Q2 ,  HNF3_Q6 ,  SP3_Q3 ,  ZID_01 ,  GTCTTCC_MIR7 ,  EVI1_05 ,  ATGCTGC_MIR103_MIR107 ,  GCACTTT_MIR175P_MIR20A_MIR106A_MIR106B_MIR20B_MIR519D ,  HNF3B_01 ,  FOXJ2_01 ,  AGTCTTA_MIR499 ,  AREB6_01 ,  TGCTGAY_UNKNOWN ,  YKACATTT_UNKNOWN ,  OCT1_03 ,  CCCNNGGGAR_OLF1_01 ,  AAGWWRNYGGC_UNKNOWN ,  NKX25_02 ,  FOXO1_01 ,  RAAGNYNNCTTY_UNKNOWN ,  TAATAAT_MIR126 ,  CTTTAAR_UNKNOWN ,  HFH4_01 ,  ATACTGT_MIR144 ,  OCT1_06 ,  YCATTAA_UNKNOWN ,  AGGGCCA_MIR328 ,  NCX_01 ,  GTGCCTT_MIR506 ,  HLF_01 ,  TCTATGA_MIR376A_MIR376B ,  NMYC_01 ,  OCT1_02 ,  FREAC2_01 ,  POU3F2_02 ,  TTGTTT_FOXO4_01 ,  CEBP_C ,  PIT1_Q6 ,  GATA4_Q3 ,  GAGCCAG_MIR149 ,  TATA_01 ,  CTGYNNCTYTAA_UNKNOWN ,  AAGCACT_MIR520F ,  RYAAAKNNNNNNTTGW_UNKNOWN ,  TCCATTKW_UNKNOWN ,  ISRE_01 ,  CDC5_01 ,  FOXM1_01 ,  TGGTGCT_MIR29A_MIR29B_MIR29C ,  AACTTT_UNKNOWN ,  MZF1_02 ,  GGCAGTG_MIR3243P ,  TGACATY_UNKNOWN ,  TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497 ,  DR4_Q2 ,  HNF1_Q6 ,  ACCATTT_MIR522 ,  FOXO4_02 ,  HNF6_Q6 ,  TATTATA_MIR374 ,  GTCAACC_MIR3805P

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-1 ,  Predicted Gene Targets for miR-103 ,  Predicted Gene Targets for miR-128 ,  Predicted Gene Targets for miR-144 ,  Predicted Gene Targets for miR-15 ,  Predicted Gene Targets for miR-18 ,  Predicted Gene Targets for miR-181 ,  Predicted Gene Targets for miR-183 ,  Predicted Gene Targets for miR-19 ,  Predicted Gene Targets for miR-193 ,  Predicted Gene Targets for miR-20 ,  Predicted Gene Targets for miR-141 ,  Predicted Gene Targets for miR-204 ,  Predicted Gene Targets for miR-21 ,  Predicted Gene Targets for miR-218 ,  Predicted Gene Targets for miR-224 ,  Predicted Gene Targets for miR-24 ,  Predicted Gene Targets for miR-26 ,  Predicted Gene Targets for miR-27 ,  Predicted Gene Targets for miR-30 ,  Predicted Gene Targets for miR-320 ,  Predicted Gene Targets for miR-324-3p ,  Predicted Gene Targets for miR-328 ,  Predicted Gene Targets for miR-365 ,  Predicted Gene Targets for miR-369-3p ,  Predicted Gene Targets for miR-381 ,  Predicted Gene Targets for miR-503 ,  Predicted Gene Targets for miR-7 ,  Predicted Gene Targets for miR-93 ,  Predicted Gene Targets for miR-376 ,  Predicted Gene Targets for miR-124a ,  Predicted Gene Targets for miR-149 ,  Predicted Gene Targets for miR-155 ,  Predicted Gene Targets for miR-29 ,  Predicted Gene Targets for miR-374 ,  Predicted Gene Targets for miR-375 ,  Predicted Gene Targets for miR-380-5p ,  Predicted Gene Targets for miR-410 ,  Predicted Gene Targets for miR-493-5p ,  Predicted Gene Targets for miR-499 ,  Predicted Gene Targets for miR-543

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miRNA binding sites
(Source: miRecords):

hsa-miR-26a Targeted Genes

Cytogenetic Map:

8q12.1

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