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QuickView for Pipecuronium (compound)
PubChem
| Name: | Pipecuronium |
|---|---|
| PubChem Compound ID: | 4475098 |
| Description: | A piperazinyl androstane derivative which is a non-depolarizing neuromuscular blocking agent (NEUROMUSCULAR NONDEPOLARIZING AGENTS). It is used as a muscle relaxant during ANESTHESIA and surgical procedures. |
| Molecular formula: | C35H62N4O4+2 |
| Molecular weight: | 602.891 g/mol |
DrugBank
Identification
| Name: | Pipecuronium |
|---|---|
| Name (isomeric): | DB01338 |
| Drug Type: | small molecule |
| Description: | A piperazinyl androstane derivative which is a non-depolarizing neuromuscular blocking agent (NEUROMUSCULAR NONDEPOLARIZING AGENTS). It is used as a muscle relaxant during ANESTHESIA and surgical procedures. |
| Synonyms: |
Pipecuronium bromide; Pipecurium
|
| Brand: | Raplon |
| Category: | Neuromuscular Nondepolarizing Agents, Nicotinic Antagonists |
| CAS number: | 68399-58-6 |
Pharmacology
| Indication: | Used as a muscle relaxant during anesthesia and surgical procedures. |
|---|---|
| Pharmacology: |
Pipecuronium is a nondepolarizing neuromuscular blocking agent. Neuromuscular blocking agents produce skeletal muscle paralysis by blocking neural transmission at the myoneural junction. The paralysis is selective initially and usually appears in the following muscles consecutively: levator muscles of eyelids, muscles of mastication, limb muscles, ...
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| Mechanism of Action: | Nondepolarizing neuromuscular blocking agents inhibit neuromuscular transmission by competing with acetylcholine for the cholinergic receptors of the motor end plate, thereby reducing the response of the end plate to acetylcholine. This type of neuromuscular block is usually antagonized by anticholinesterase agents. |
| Half Life: | Distribution Normal renal function: 6.22 (range, 1.34 to 10.66) minutes. Renal function impairment: 4.33 (range, 1.69 to 6.17) minutes. Elimination Normal renal function: 1.7 (range, 0.9 to 2.7) hours. The elimination half-life is not altered by hypothermia and bypass. Renal function impairment: 4 (range, 2 to 8.2) hours. [PharmGKB] |
| Affected organisms: | Humans and other mammals |
Interactions
| Drug interaction: |
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Targets
