QuickView for RB1 (gene)

Gene Symbol:

RB1 Homo sapiens

Full name:

RB transcriptional corepressor 1

Synonyms:

OSRC, PPP1R130, RB, p105-Rb, pRb, pp110, retinoblastoma-associated protein, GOS563 exon 17 substitution mutation causes premature stop, exon 17 tumor GOS561 substitution mutation causes premature stop, prepro-retinoblastoma-associated protein, protein phosphatase 1, regulatory subunit 130, retinoblastoma 1, retinoblastoma suspectibility protein

Genomic Location:

Chr 13: 47775884-47954027

Description:

The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause o...

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The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TAGGTCA_MIR192_MIR215 ,  ATACCTC_MIR202 ,  GCACTTT_MIR175P_MIR20A_MIR106A_MIR106B_MIR20B_MIR519D ,  CTCTGGA_MIR520A_MIR525 ,  TGCACTT_MIR519C_MIR519B_MIR519A

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for let-7 ,  Predicted Gene Targets for miR-143 ,  Predicted Gene Targets for miR-192 ,  Predicted Gene Targets for miR-20 ,  Predicted Gene Targets for miR-33 ,  Predicted Gene Targets for miR-7

miRNA binding sites
(Source: miRecords):

hsa-miR-106a Targeted Genes

Cytogenetic Map:

13q14.2

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