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QuickView for Rabeprazole (compound)

Name: rabeprazole
PubChem Compound ID: 10786084
Molecular formula: C18H20N3NaO3S
Molecular weight: 381.426 g/mol
Name: rabeprazole
Name (isomeric): DB01129
Drug Type: small molecule
Rebeprazole sodium; rabeprazole sodium; Irsogladine Maleate
Brand: AcipHex, Pariet
Category: Anti-Ulcer Agents, Enzyme Inhibitors
CAS number: 117976-89-3
Indication: For the treatment of acid-reflux disorders (GERD), peptic ulcer disease, H. pylori eradication, and prevention of gastroinetestinal bleeds with NSAID use.
Rabeprazole prevents the production of acid in the stomach. It reduces symptoms and prevents injury to the esophagus or stomach in patients with gastroesophageal reflux disease (GERD) or ulcers. Rabeprazole is also useful in conditions that produce too much stomach acid such as Zollinger-Ellison syndrome. Rabeprazole may also be used with antibioti...
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Mechanism of Action:
Rabeprazole belongs to a class of antisecretory compounds (substituted benzimidazole proton-pump inhibitors) that do not exhibit anticholinergic or histamine H2-receptor antagonist properties, but suppress gastric acid secretion by inhibiting the gastric H+/K+ATPase (hydrogen-potassium adenosine triphosphatase) at the secretor...
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Absorption: Absolute bioavailability is approximately 52%.
Protein binding: 96.3% (bound to human plasma proteins)
Biotransformation: Hepatic
Route of elimination: Following a single 20 mg oral dose of 14C-labeled rabeprazole, approximately 90% of the drug was eliminated in the urine, primarily as thioether carboxylic acid; its glucuronide, and mercapturic acid metabolites.
Half Life: 1-2 hours (in plasma)
Affected organisms: Humans and other mammals
Food interaction:
Take without regard to meals.
Take without regard to meals. Food may slow absorption rate but extent of absorption is not affected.
Drug interaction:
TretinoinThe moderate CYP2C8 inhibitor, Rabaprazole, may decrease the metabolism and clearance of oral Tretinoin. Monitor for changes in Tretinoin effectiveness and adverse/toxic effects if Rabaprazole is initiated, discontinued to dose changed.
IndinavirOmeprazole decreases the absorption of indinavir
CefditorenProton pump inhibitors such as rabeprazole may decrease the serum concentration of cefditoren. If possible, avoid use of cefditoren with proton pump inhibitors (PPIs). Consider alternative methods to minimize/control acid reflux (eg, diet modification) or alternative antimicrobial therapy if use of PPIs can not be avoided.
ItraconazoleThe proton pump inhibitor, rabeprazole, may decrease the absorption of itraconazole.
DigoxinRabeprazole increases the effect of digoxin
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