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PubChem
Name: Gallamine Triethiodide
PubChem Compound ID: 3450
Description: A synthetic nondepolarizing blocking drug. The actions of gallamine triethiodide are similar to those of TUBOCURARINE, but this agent blocks the cardiac vagus and may cause sinus tachycardia and, occasionally, hypertension and increased cardiac output. It should be used cautiously in patients at risk from increased heart rate but may be preferred for patients with bradycardia. (From AMA Drug Evaluations Annual, 1992, p198)
Molecular formula: C30H60N3O3+3
Molecular weight: 510.816 g/mol
Synonyms:
NCGC00015482-01; 1,2, 3-Tris (2-diethylaminoethoxy)benzene tris(ethyliodide); Retensin; NCGC00015482-02; Sincurarine; Spectrum3_000439; 1,2, 3-Tri(.beta.-diethylaminoethoxy)benzene triethiodide; F 2559; Gallamine triiodoethylate; Spectrum4_000561.
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DrugBank
Identification
Name: Gallamine Triethiodide
Name (isomeric): DB00483
Drug Type: small molecule
Description: A synthetic nondepolarizing blocking drug. The actions of gallamine triethiodide are similar to those of TUBOCURARINE, but this agent blocks the cardiac vagus and may cause sinus tachycardia and, occasionally, hypertension and increased cardiac output. It should be used cautiously in patients at risk from increased heart rate but may be preferred for patients with bradycardia. (From AMA Drug Evaluations Annual, 1992, p198)
Synonyms:
Gallamin; Gallamine Iodide; Gallamone Triethiodide; Gallamin Triethiodide; Triiodoethylate de Gallamine; Gallamine; Benzcurine Iodide; Gallamonum; Benzkurin; Gallamine Triiodoethylate.
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Brand: Remyolan, Flacedil, Fourneau 2559, Sincurarine, Syncurarine, Pyrolaxon, Parexyl, Retensin, Pirolakson, Relaxan, Miowas G, Tricuran, Gallaflex, Flaxedil
Category: Neuromuscular Nondepolarizing Agents, Nicotinic Antagonists, Skeletal Muscle Relaxants
CAS number: 65-29-2
Pharmacology
Indication: For use as adjuncts to anesthesia to induce skeletal muscle relaxation and to facilitate the management of patients undergoing mechanical ventilation
Pharmacology:
Gallamine Triethiodide is a nondepolarizing neuromuscular blocking drug (NDMRD) used as an adjunct to anesthesia to induce skeletal muscle relaxation. The actions of gallamine triethiodide are similar to those of tubocurarine, but this agent blocks the cardiac vagus and may cause sinus tachycardia and, occasionally, hypertension and increased cardi...
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Mechanism of Action:
It competes with acetylcholine (ACh) molecules and binds to muscarinic acetylcholine receptors on the post-synaptic membrane of the motor endplate. It acts by combining with the cholinergic receptor sites in muscle and competitively blocking the transmitter action of acetylcholine. It blocks the action of ACh and prevents activation of the muscle c...
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Affected organisms: Humans and other mammals

Targets