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QuickView for hyaluronan (compound)

Name: Hyaluronan
Name (isomeric): DB08818
Drug Type: small molecule
Sodium hyaluronate; Hyaluronic acid sodium salt; Hyaluronate; Hyaluronic acid
Brand: Viscure, Yardel, Recosyn, Hylo-Comod, Synvisc, Hyalart, Euflexxa, Monovisc, Legend, Hyalgan, AMO Vitrax, AMVISIC Plus, Gonilert, Cystistar
Category: Anti-inflammatory Agents
CAS number: 9067-32-7
Indication: Used to treat knee pain in patients with joint inflammation (osteoarthritis). It is usually used in patients who have not responded to other treatments such as acetaminophen, exercise, or physical therapy. Sodium hyaluronate may also be used in plastic surgery to reduce wrinkles on the face or as a filler in other parts of the body. May be used in ophthalmology to assist in the extraction of cataracts, the implantation of intraocular lenses, corneal transplants, glaucoma filtration, retinal attachment and in the treatment of dry eyes. Finally, Sodium hyaluronate is also used to coat the bladder lining in treating interstitial cystitis.
Pharmacology: Hyaluronan is similar to a substance that occurs naturally in the joints. It may work by acting as a lubricant and shock absorber in the joint, helping the knee to move smoothly, thereby lessening pain.
Mechanism of Action:
Hyaluronan functions as a tissue lubricant and is thought to play an important role in modulating the interactions between adjacent tissues. Sodium hyaluronate is a polysaccharide which is distributed widely in the extracellular matrix of connective tissue in man. It forms a viscoelastic solution in water which makes it suitable for aqueous and vit...
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Absorption: Hyaluronan is absorbed and diffuses slowly out of the injection site.
Biotransformation: Hyaluronan is degraded by a family of enzymes called hyaluronidases.
Route of elimination: Hyaluronan is eliminated via the canal of Schlemm.
Toxicity: >2400 mg/kg (mouse, oral, sodium salt) >4000 mg/kg (mouse, subcutaneous, sodium salt) 1500 mg/kg (mouse, intraperitoneal, sodium salt)
Affected organisms: Humans and other mammals