QuickView for nandrolone decanoate (compound)

Summary
General Info

PubChem

PubChem Compound 4432

Name:	nandrolone decanoate
PubChem Compound ID:	4432
Molecular formula:	C₂₈H₄₄O₃
Molecular weight:	428.647 g/mol
Synonyms:	Estr-4-en-3-one, 17-.beta.-hydroxy-, decanoate; Estr-4-en-3-one, 17-[(1-oxodecyl)oxy]-, (17.beta.)-

DrugBank

Identification

Name:	nandrolone decanoate
Name (isomeric):	DB08804
Drug Type:	small molecule
Synonyms:	Norandrostenolone decanoate; Nortestosterone decanoate
Brand:	Deca Durabolin, Retabolil, Deca-Durabol, Deca-durabolin
Category:	Anabolic Agents, Androgens
CAS number:	360-70-3

Pharmacology

Indication:	For the treatment of refractory deficient red cell production anemias, breast carcinoma, hereditary angioedema, antithrombin III deficiency, fibrinogen excess, growth failure and Turner's syndrome. It is also indicated in the prophylaxis of hereditary angioedema.
Pharmacology:	Nandrolone is an anabolic steroid occurring naturally in the human body, albeit in small quantities. Nandrolone increases production and urinary excretion of erythropoietin. It may also have a direct action on bone marrow. Nandrolone binds to the androgen receptor to a greater degree than testosterone, but due to its inability to act on the muscle ... show more » Nandrolone is an anabolic steroid occurring naturally in the human body, albeit in small quantities. Nandrolone increases production and urinary excretion of erythropoietin. It may also have a direct action on bone marrow. Nandrolone binds to the androgen receptor to a greater degree than testosterone, but due to its inability to act on the muscle in ways unmediated by the receptor, has less overall effect on muscle growth. show less «
Mechanism of Action:	Nandrolone is an androgen receptor agonist. The drug bound to the receptor complexes which allows it to enter the nucleus and bind directly to specific nucleotide sequences of the chromosomal DNA. The areas of binding are called hormone response elements (HREs), and influence transcriptional activity of certain genes, producing the androgen effects... show more » Nandrolone is an androgen receptor agonist. The drug bound to the receptor complexes which allows it to enter the nucleus and bind directly to specific nucleotide sequences of the chromosomal DNA. The areas of binding are called hormone response elements (HREs), and influence transcriptional activity of certain genes, producing the androgen effects. show less «
Protein binding:	58%
Biotransformation:	Nandrolone is unusual in that unlike most anabolic steroids, it is not broken down into the more reactive DHT by the enzyme 5α-reductase, but rather into a less effective product known as Dihydronandrolone.
Affected organisms:	Humans and other mammals

Interactions

Drug interaction:

Warfarin

Nandrolone may increase the serum concentration and anticoagulant effect of warfarin. Monitor for changes in prothrombin time and therapeutic effects of warfarin if nandrolone is initiated, discontinued or dose changed.

Targets

Androgen receptor