QuickView for HNPCC;jsessionid=EB451450E5E9ACED2131B18507A1285B (gene)
- Gene Symbol:
- MLH1
Bos taurus - Full name:
- mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)
- Synonyms:
- MGC140127
- Genomic Location:
- Chr 22: 10500212-10593819
- Orthologs:
- Homo sapiens , Mus musculus , Rattus norvegicus , D. melanogaster , C. elegans , Saccharomyces cerevisiae , Macaca mulatta , Schizosaccharomyces pombe , Danio rerio , Gallus gallus , Canis lupus familiaris , Pan troglodytes
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
GO Molecular Function
MutSalpha complex binding | nucleic acid binding | protein-containing complex binding | ribonucleotide binding | nucleotide binding | mismatched DNA binding | carbohydrate derivative binding | chromatin binding | ATP binding | anion binding | adenyl nucleotide binding | DNA binding | purine nucleotide binding | ion binding | organic cyclic compound binding | guanine/thymine mispair binding | purine ribonucleoside triphosphate binding | double-stranded DNA binding | purine ribonucleotide binding | adenyl ribonucleotide binding | drug binding | heterocyclic compound binding | small molecule binding
GO Biological Process
positive regulation of immune response | RNA metabolic process | double-strand break repair | adaptive immune response | meiotic metaphase plate congression | regulation of B cell activation | developmental process involved in reproduction | intracellular signal transduction | establishment of localization | regulation of immune system process | negative regulation of cellular process | positive regulation of developmental process | positive regulation of lymphocyte activation | microtubule cytoskeleton organization | cell differentiation | male gamete generation | intrinsic apoptotic signaling pathway in response to DNA damage | male meiosis chromosome segregation | male meiotic nuclear division | positive regulation of DNA recombination | negative regulation of DNA metabolic process | microtubule-based process | regulation of isotype switching to IgG isotypes | cellular process | synapsis | organic substance catabolic process | establishment of organelle localization | localization | positive regulation of immune effector process | resolution of meiotic recombination intermediates | positive regulation of adaptive immune response | immune system development | multicellular organismal reproductive process | positive regulation of nitrogen compound metabolic process | spindle midzone assembly | spindle assembly | establishment of localization in cell | negative regulation of cellular metabolic process | gamete generation | intrinsic apoptotic signaling pathway | regulation of immune response | regulation of cellular process | leukocyte activation | regulation of metabolic process | catabolic process | organelle localization | organic cyclic compound metabolic process | positive regulation of isotype switching to IgA isotypes | cellular aromatic compound metabolic process | meiotic telomere clustering | cellular component organization | establishment of chromosome localization | mRNA catabolic process | response to stimulus | female gamete generation | regulation of DNA recombination | female meiosis chromosome segregation | chromosome segregation | positive regulation of immune system process | positive regulation of immunoglobulin production | response to stress | leukocyte activation involved in immune response | germ cell development | programmed cell death | positive regulation of cell activation | reproduction | cellular localization | cellular nitrogen compound metabolic process | double-strand break repair via nonhomologous end joining | negative regulation of metabolic process | cellular component assembly | mRNA metabolic process | nuclear-transcribed mRNA catabolic process | DNA recombination | nucleobase-containing compound catabolic process | meiotic chromosome segregation | DNA repair | meiotic chromosome separation | apoptotic process | organelle assembly | adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains | system development | nitrogen compound metabolic process | reproductive process | multicellular organism development | telomere localization | cellular response to DNA damage stimulus | leukocyte mediated immunity | somatic recombination of immunoglobulin gene segments | regulation of gene expression | cellular response to stress | cell cycle | RNA catabolic process | positive regulation of cellular metabolic process | regulation of lymphocyte activation | regulation of nitrogen compound metabolic process | oogenesis | nuclear-transcribed mRNA poly(A) tail shortening | meiotic spindle midzone assembly | B cell activation | metaphase plate congression | positive regulation of immunoglobulin mediated immune response | positive regulation of isotype switching | nuclear chromosome segregation | cell communication | regulation of cellular metabolic process | cell activation involved in immune response | meiotic metaphase I plate congression | aromatic compound catabolic process | chromosome localization to nuclear envelope involved in homologous chromosome segregation | positive regulation of B cell activation | apoptotic signaling pathway | lymphocyte activation | multicellular organism reproduction | homologous chromosome segregation | DNA metabolic process | reciprocal meiotic recombination | cellular macromolecule catabolic process | anatomical structure development | nuclear division | metabolic process | regulation of isotype switching | immunoglobulin production involved in immunoglobulin mediated immune response | immunoglobulin production | regulation of adaptive immune response | positive regulation of leukocyte activation | regulation of mitotic recombination | somatic diversification of immunoglobulins | immune response | nucleobase-containing compound metabolic process | organic substance metabolic process | cell death | negative regulation of gene expression | regulation of cell activation | cytoskeleton organization | chromosome organization involved in meiotic cell cycle | meiosis I | cell activation | negative regulation of DNA recombination | somatic recombination of immunoglobulin genes involved in immune response | meiotic cell cycle | negative regulation of mitotic recombination | signaling | regulation of immunoglobulin production | cell development | B cell activation involved in immune response | somatic cell DNA recombination | homologous recombination | regulation of developmental process | B cell mediated immunity | positive regulation of DNA metabolic process | developmental process | organelle organization | spermatogenesis | positive regulation of isotype switching to IgG isotypes | heterocycle metabolic process | positive regulation of metabolic process | chromosome organization | isotype switching | immunoglobulin mediated immune response | immune system process | cellular metabolic process | chromosome separation | spindle organization | nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay | sexual reproduction | signal transduction | female meiotic nuclear division | macromolecule metabolic process | multicellular organismal process
GO Cellular Component
condensed nuclear chromosome | chromosome | intracellular membrane-bounded organelle | cell | nuclear lumen | intracellular organelle | germ cell nucleus | recombination nodule | nucleoplasm | nuclear chromosome | membrane-bounded organelle | nucleus | late recombination nodule | organelle | membrane-enclosed lumen | intracellular | male germ cell nucleus | condensed chromosome
