QuickView for Hif-1a;jsessionid=98E78F8D57293491000D013BE664D6F3;jsessionid=2C895902792A07DC05D70581D19A4C7B;jsessionid=53ACE338966D43544FEF957E694529B2;jsessionid=A3504870749F1B59546C89BB6B05E45F (gene)

Gene Symbol:

Hif1a Mus musculus

Full name:

hypoxia inducible factor 1, alpha subunit

Synonyms:

AA959795, HIF-1-alpha, HIF1-alpha, HIF1alpha, MOP1, bHLHe78, hypoxia-inducible factor 1-alpha, ARNT-interacting protein

Genomic Location:

Chr 12: 75009017-75047878

Description:

This gene encodes the alpha subunit which, along with the beta subunit, forms a heterodimeric transcription factor that regulates the cellular and developmental response to reduced oxygen tension. The transcription factor has been shown to regulate genes involved in several biological processes, including erythropoiesis and angiogenesis which aid i...

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This gene encodes the alpha subunit which, along with the beta subunit, forms a heterodimeric transcription factor that regulates the cellular and developmental response to reduced oxygen tension. The transcription factor has been shown to regulate genes involved in several biological processes, including erythropoiesis and angiogenesis which aid in increased delivery of oxygen to hypoxic regions. The transcription factor also plays a role in the induction of genes involved in cell proliferation and survival, energy metabolism, apoptosis, and glucose and iron metabolism. Alternative splicing results in multiple transcript variants encoding different isoforms.

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Orthologs:

Homo sapiens ,  Rattus norvegicus ,  Macaca mulatta ,  Bos taurus ,  Gallus gallus ,  Danio rerio ,  Canis lupus familiaris ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

AACTTT_UNKNOWN ,  HEN1_01 ,  MYCMAX_02 ,  NFY_01 ,  CCCNNNNNNAAGWT_UNKNOWN ,  AREB6_01 ,  TGIF_01 ,  HIF1_Q5 ,  AP2ALPHA_01 ,  AP2GAMMA_01 ,  ARNT_02 ,  TCF1P_Q6 ,  ZF5_01 ,  CACBINDINGPROTEIN_Q6 ,  CACCCBINDINGFACTOR_Q6 ,  SREBP1_Q6 ,  NFY_Q6_01 ,  SREBP_Q3 ,  YY1_Q6 ,  USF_Q6_01 ,  CP2_02 ,  GCACTTT_MIR175P_MIR20A_MIR106A_MIR106B_MIR20B_MIR519D ,  TGCACTT_MIR519C_MIR519B_MIR519A ,  CACTTTG_MIR520G_MIR520H ,  AAGCCAT_MIR135A_MIR135B ,  ACACTGG_MIR199A_MIR199B ,  GCACCTT_MIR18A_MIR18B ,  ACTGCAG_MIR173P ,  GGTGAAG_MIR412 ,  AGCATTA_MIR155 ,  RNGTGGGC_UNKNOWN ,  TTTTGAG_MIR373 ,  ATCATGA_MIR433 ,  WTGAAAT_UNKNOWN ,  WTTGKCTG_UNKNOWN ,  CAGCTG_AP4_Q5 ,  CAGGTG_E12_Q6 ,  TTGTTT_FOXO4_01 ,  TGACAGNY_MEIS1_01 ,  CACGTG_MYC_Q2 ,  TGGAAA_NFAT_Q4_01 ,  GATTGGY_NFY_Q6_01 ,  GGGTGGRR_PAX4_03 ,  TCANNTGAY_SREBP1_01 ,  GCCATNTTG_YY1_Q6

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-135 ,  Predicted Gene Targets for miR-138 ,  Predicted Gene Targets for miR-18 ,  Predicted Gene Targets for miR-19 ,  Predicted Gene Targets for miR-199 ,  Predicted Gene Targets for miR-20 ,  Predicted Gene Targets for miR-433-3p ,  Predicted Gene Targets for miR-155 ,  Predicted Gene Targets for miR-376c ,  Predicted Gene Targets for miR-495

miRNA binding sites
(Source: miRecords):

mmu-miR-31 Targeted Genes

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