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QuickView for Kog1;jsessionid=5FF72406106ED25F8E2BA24EBD5FD91E;jsessionid=B6700F831FE5E582370CB5180BBB986A (gene)


Gene Symbol:
Rptor Mus musculus Mus musculus
Full name:
regulatory associated protein of MTOR, complex 1
Synonyms:
4932417H02Rik, Rap, Raptor, mKIAA1303, regulatory-associated protein of mTOR, p150 target of rapamycin (TOR)-scaffold protein
Genomic Location:
Chr 11: 119465124-119758796
Description:
This gene encodes a subunit of mammalian target of rapamycin complex 1 (mTORC1), a component of the mTOR signaling pathway, which regulates cell growth in response to nutrient and energy levels. The encoded protein may regulate the assembly, localization, and substrate binding of the mTORC1 complex. Homozygous knockout mice for this gene exhibit em...
Orthologs:
Homo sapiens Rattus norvegicus D. melanogaster C. elegans Saccharomyces cerevisiae Macaca mulatta Schizosaccharomyces pombe Gallus gallus Pan troglodytes Bos taurus Danio rerio Canis lupus familiaris
External Links:
Entrez Gene





GO Molecular Function

sequence-specific DNA binding | protein kinase activator activity | kinase binding | enzyme activator activity | protein kinase regulator activity | transcription regulatory region DNA binding | protein serine/threonine kinase inhibitor activity | kinase regulator activity | 14-3-3 protein binding | protein kinase inhibitor activity | protein kinase binding | enzyme binding | nucleic acid binding | protein-containing complex binding | enzyme inhibitor activity | molecular function regulator | protein binding, bridging | DNA binding | sequence-specific double-stranded DNA binding | organic cyclic compound binding | molecular adaptor activity | protein binding | double-stranded DNA binding | transcription factor binding | kinase inhibitor activity | kinase activator activity | rDNA binding | RNA polymerase III type 1 promoter DNA binding | TFIIIC-class transcription factor binding | RNA polymerase III type 2 promoter DNA binding | enzyme regulator activity | RNA polymerase III regulatory region DNA binding | heterocyclic compound binding | RNA polymerase III type 3 promoter DNA binding

GO Biological Process

response to extracellular stimulus | negative regulation of phosphorylation | regulation of cell cycle process | protein kinase activator activity | positive regulation of macromolecule biosynthetic process | response to nutrient levels | TORC1 signaling | negative regulation of peptide secretion | intracellular signal transduction | enzyme activator activity | regulation of localization | regulation of cell cycle G1/S phase transition | protein kinase regulator activity | positive regulation of G1/S transition of mitotic cell cycle | positive regulation of peptidyl-threonine phosphorylation | negative regulation of cellular process | negative regulation of kinase activity | positive regulation of epithelial cell proliferation | protein serine/threonine kinase inhibitor activity | cellular response to extracellular stimulus | negative regulation of protein phosphorylation | regulation of G1/S transition of mitotic cell cycle | positive regulation of phosphate metabolic process | negative regulation of protein secretion | positive regulation of endothelial cell proliferation | regulation of peptide hormone secretion | positive regulation of cellular biosynthetic process | cellular process | negative regulation of signaling | positive regulation of peptidyl-serine phosphorylation | kinase regulator activity | TOR signaling | protein kinase inhibitor activity | response to leucine | positive regulation of protein kinase activity | negative regulation of secretion | cellular response to starvation | regulation of cell cycle | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | negative regulation of hormone secretion | negative regulation of establishment of protein localization | negative regulation of cellular metabolic process | regulation of transcription by RNA polymerase III | regulation of cellular process | positive regulation of cell growth | regulation of metabolic process | positive regulation of cell cycle phase transition | positive regulation of cellular protein metabolic process | cellular response to organonitrogen compound | cellular component organization | regulation of peptide secretion | response to stimulus | enzyme inhibitor activity | negative regulation of protein transport | regulation of mitotic cell cycle phase transition | regulation of insulin secretion | positive regulation of protein metabolic process | response to stress | negative regulation of protein kinase activity | regulation of cell proliferation | regulation of cell cycle phase transition | response to starvation | positive regulation of transcription by RNA polymerase III | negative regulation of transport | regulation of protein transport | negative regulation of metabolic process | regulation of cellular component size | positive regulation of protein serine/threonine kinase activity | positive regulation of RNA biosynthetic process | regulation of peptide transport | regulation of TOR signaling | activation of protein kinase activity | molecular function regulator | regulation of nucleic acid-templated transcription | response to nitrogen compound | cellular response to nutrient levels | regulation of signal transduction | negative regulation of secretion by cell | negative regulation of phosphate metabolic process | negative regulation of catalytic activity | response to amino acid | regulation of catalytic activity | regulation of protein serine/threonine kinase activity | regulation of phosphorylation | regulation of hormone levels | regulation of hormone secretion | positive regulation of cell cycle | positive regulation of mitotic cell cycle | regulation of gene expression | cellular response to stress | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | regulation of nitrogen compound metabolic process | positive regulation of intracellular signal transduction | negative regulation of protein serine/threonine kinase activity | regulation of cellular protein metabolic process | negative regulation of peptide hormone secretion | cellular response to leucine | cellular response to amino acid stimulus | positive regulation of cell cycle G1/S phase transition | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | regulation of protein metabolic process | positive regulation of signal transduction | positive regulation of TOR signaling | positive regulation of cell proliferation | regulation of protein phosphorylation | regulation of RNA metabolic process | regulation of mitotic cell cycle | positive regulation of molecular function | regulation of establishment of protein localization | positive regulation of protein modification process | regulation of growth | response to organic substance | kinase inhibitor activity | regulation of kinase activity | regulation of intracellular signal transduction | kinase activator activity | positive regulation of mitotic cell cycle phase transition | regulation of RNA biosynthetic process | regulation of secretion | regulation of endothelial cell proliferation | negative regulation of cellular protein metabolic process | regulation of protein secretion | positive regulation of kinase activity | regulation of phosphate metabolic process | regulation of peptidyl-serine phosphorylation | negative regulation of protein metabolic process | regulation of cell communication | negative regulation of molecular function | negative regulation of insulin secretion | signaling | positive regulation of growth | regulation of transcription, DNA-templated | regulation of epithelial cell proliferation | positive regulation of phosphorylation | regulation of cell size | enzyme regulator activity | positive regulation of cell cycle process | regulation of cell growth | regulation of transport | positive regulation of transcription, DNA-templated | positive regulation of nucleic acid-templated transcription | response to organonitrogen compound | positive regulation of metabolic process | cellular response to organic substance | regulation of protein localization | regulation of cellular component organization | positive regulation of signaling | signal transduction | regulation of signaling | positive regulation of gene expression | regulation of phosphorus metabolic process

GO Cellular Component

dendrite | intracellular membrane-bounded organelle | neuron projection | somatodendritic compartment | cytoplasmic stress granule | cell body | cell | nuclear lumen | neuronal cell body | ribonucleoprotein granule | cytoplasm | intracellular organelle | dendritic tree | protein-containing complex | cell projection | nucleoplasm | vacuole | ribonucleoprotein complex | TORC1 complex | lytic vacuole | membrane-bounded organelle | nucleus | organelle | cytoplasmic ribonucleoprotein granule | lysosome | membrane-enclosed lumen | cytosol | intracellular