QuickView for RB1;jsessionid=BB236F7730C72FD55BC405789529EDCF;jsessionid=26C7A6932B415979FCB13C884E042358 (gene)
- Gene Symbol:
- Rb1
Mus musculus - Full name:
- RB transcriptional corepressor 1
- Synonyms:
- Rb, Rb-1, pRb, retinoblastoma-associated protein, pp105, retinoblastoma 1
- Genomic Location:
- Chr 14: 73595309-73725547
- Orthologs:
- Homo sapiens , Rattus norvegicus , Macaca mulatta , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Bos taurus , Danio rerio
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan):
GO Molecular Function
sequence-specific DNA binding | kinase binding | transcription regulatory region DNA binding | RNA polymerase II transcription factor activity, sequence-specific DNA binding | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | proximal promoter sequence-specific DNA binding | enzyme binding | RNA polymerase II activating transcription factor binding | nucleic acid binding | disordered domain specific binding | importin-alpha family protein binding | protein domain specific binding | ubiquitin-like protein ligase binding | RNA polymerase II regulatory region DNA binding | DNA binding | sequence-specific double-stranded DNA binding | transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | identical protein binding | organic cyclic compound binding | transcription regulatory region sequence-specific DNA binding | phosphoprotein binding | protein binding | double-stranded DNA binding | DNA-binding transcription factor activity | transcription factor binding | ubiquitin protein ligase binding | RNA polymerase II transcription factor binding | activating transcription factor binding | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | heterocyclic compound binding
GO Biological Process
RNA metabolic process | negative regulation of phosphorylation | regulation of supramolecular fiber organization | cell morphogenesis | regulation of cell cycle process | negative regulation of hepatocyte apoptotic process | positive regulation of macromolecule biosynthetic process | positive regulation of cellular component organization | regulation of cellular localization | muscle tissue development | regulation of localization | regulation of cell cycle G1/S phase transition | regulation of programmed cell death | erythrocyte homeostasis | epithelial cell apoptotic process | regulation of immune system process | myeloid cell differentiation | neuron death | negative regulation of cellular process | negative regulation of kinase activity | RNA polymerase II transcription factor activity, sequence-specific DNA binding | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | positive regulation of developmental process | negative regulation of RNA biosynthetic process | cell differentiation | nervous system development | regulation of extracellular matrix organization | negative regulation of protein phosphorylation | regulation of G1/S transition of mitotic cell cycle | neurogenesis | regulation of organelle organization | generation of neurons | tissue homeostasis | enucleate erythrocyte differentiation | regulation of chromosome segregation | positive regulation of cellular biosynthetic process | cellular process | negative regulation of inflammatory response | localization | chromatin organization | cell maturation | negative regulation of signaling | neuron development | negative regulation of G1/S transition of mitotic cell cycle | regulation of mitotic nuclear division | immune system development | negative regulation of nucleic acid-templated transcription | regulation of chromosome separation | macromolecule localization | negative regulation of apoptotic process | regulation of cell cycle | regulation of myeloid cell differentiation | positive regulation of nitrogen compound metabolic process | negative regulation of myofibroblast differentiation | regulation of smoothened signaling pathway | negative regulation of cellular metabolic process | tissue development | regulation of binding | regulation of myeloid leukocyte differentiation | regulation of cell differentiation | muscle structure development | anatomical structure homeostasis | muscle cell differentiation | skeletal muscle organ development | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | positive regulation of extracellular matrix organization | positive regulation of cell cycle phase transition | organic cyclic compound metabolic process | RNA biosynthetic process | cellular aromatic compound metabolic process | cellular component organization | response to stimulus | negative regulation of epithelial cell apoptotic process | positive regulation of collagen fibril organization | cell morphogenesis involved in neuron differentiation | regulation of cellular protein localization | regulation of mitotic cell cycle phase transition | chromosome segregation | positive regulation of immune system process | sister chromatid biorientation | cellular response to xenobiotic stimulus | negative regulation of protein kinase activity | skeletal muscle tissue development | cellular nitrogen compound biosynthetic process | regulation of cell proliferation | multicellular organismal homeostasis | regulation of cell cycle phase transition | programmed cell death | regulation of transcription regulatory region DNA binding | cellular localization | cellular nitrogen compound metabolic process | cell cycle G1/S phase transition | regulation of DNA binding | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | hemopoiesis | cellular biosynthetic process | myeloid cell homeostasis | positive regulation of macrophage differentiation | regulation of nucleic acid-templated transcription | apoptotic process | system development | nitrogen compound metabolic process | regulation of signal transduction | negative regulation of mitotic cell cycle phase transition | positive regulation of organelle organization | negative regulation of phosphate metabolic process | multicellular organism development | negative regulation of catalytic activity | positive regulation of mitotic metaphase/anaphase transition | positive regulation of chromosome separation | sister chromatid segregation | negative regulation of cold-induced thermogenesis | regulation of catalytic activity | regulation of phosphorylation | maintenance of mitotic sister chromatid cohesion | positive regulation of chromosome organization | positive regulation of cell cycle | positive regulation of mitotic cell cycle | regulation of gene expression | mitotic sister chromatid cohesion | cell cycle | positive regulation of cellular metabolic process | glial cell apoptotic process | regulation of mitotic sister chromatid separation | regulation of nitrogen compound metabolic process | neuron apoptotic process | regulation of transcription by RNA polymerase II | transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | protein localization to organelle | positive regulation of cell differentiation | positive regulation of myeloid cell differentiation | regulation of cohesin loading | homeostasis of number of cells | biosynthetic process | cell division | aortic valve morphogenesis | regulation of cellular protein metabolic process | aromatic compound biosynthetic process | hepatocyte apoptotic process | digestive tract development | response to xenobiotic stimulus | mitotic cell cycle phase transition | regulation of epithelial cell apoptotic process | cell morphogenesis involved in differentiation | nuclear chromosome segregation | regulation of lipid kinase activity | striated muscle tissue development | regulation of cellular metabolic process | regulation of protein kinase activity | semi-lunar valve development | regulation of protein metabolic process | regulation of transcription involved in G1/S transition of mitotic cell cycle | heart development | homeostatic process | G1/S transition of mitotic cell cycle | regulation of protein phosphorylation | regulation of RNA metabolic process | striated muscle cell differentiation | regulation of mitotic cell cycle | neuron maturation | positive regulation of molecular function | regulation of sister chromatid cohesion | neuron differentiation | heart valve development | negative regulation of epithelial cell proliferation | DNA-binding transcription factor activity | regulation of growth | digestive system development | regulation of hemopoiesis | cell cycle arrest | protein localization to chromosome, centromeric region | regulation of kinase activity | regulation of sister chromatid segregation | anatomical structure development | positive regulation of mitotic cell cycle phase transition | mitotic cell cycle | nuclear division | cell projection organization | metabolic process | positive regulation of supramolecular fiber organization | regulation of RNA biosynthetic process | developmental maturation | negative regulation of transcription, DNA-templated | negative regulation of programmed cell death | negative regulation of mitotic cell cycle | cellular protein localization | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | nucleobase-containing compound metabolic process | neuron projection development | heart valve morphogenesis | organic substance metabolic process | cell death | negative regulation of biosynthetic process | negative regulation of gene expression | animal organ development | negative regulation of cellular protein metabolic process | gene expression | positive regulation of chromosome segregation | regulation of phosphate metabolic process | regulation of chromosome organization | mitotic nuclear division | positive regulation of binding | transcription, DNA-templated | attachment of spindle microtubules to kinetochore | negative regulation of cell cycle | regulation of protein localization to chromatin | negative regulation of protein metabolic process | regulation of mitotic sister chromatid segregation | regulation of cell communication | negative regulation of cell cycle G1/S phase transition | regulation of macrophage differentiation | negative regulation of molecular function | negative regulation of signal transduction | regulation of transcription, DNA-templated | myoblast differentiation | cell development | positive regulation of DNA binding | protein localization | regulation of epithelial cell proliferation | anatomical structure morphogenesis | cellular macromolecule localization | cellular macromolecule biosynthetic process | regulation of developmental process | developmental process | organelle organization | negative regulation of smoothened signaling pathway | erythrocyte differentiation | positive regulation of cell cycle process | regulation of cell growth | sister chromatid cohesion | positive regulation of mitotic sister chromatid separation | negative regulation of transcription by RNA polymerase II | tube development | positive regulation of transcription, DNA-templated | aortic valve development | negative regulation of cell proliferation | regulation of mitotic metaphase/anaphase transition | positive regulation of nucleic acid-templated transcription | cell cycle phase transition | positive regulation of transcription by RNA polymerase II | heterocycle metabolic process | regulation of lipid metabolic process | positive regulation of metabolic process | chromosome organization | positive regulation of myeloid leukocyte differentiation | immune system process | cellular metabolic process | hematopoietic or lymphoid organ development | negative regulation of cell cycle process | regulation of protein localization | regulation of cell death | negative regulation of cell death | circulatory system development | regulation of inflammatory response | mitotic sister chromatid segregation | skeletal muscle cell differentiation | negative regulation of cell differentiation | regulation of cellular component organization | negative regulation of transcription involved in G1/S transition of mitotic cell cycle | muscle organ development | positive regulation of mitotic nuclear division | protein localization to chromosome | regulation of signaling | positive regulation of gene expression | positive regulation of transcription regulatory region DNA binding | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process
GO Cellular Component
nuclear transcription factor complex | chromosome | intracellular membrane-bounded organelle | catalytic complex | RNA polymerase II transcription factor complex | transcription elongation factor complex | protein kinase complex | cell | nuclear lumen | transcription factor complex | Rb-E2F complex | cyclin/CDK positive transcription elongation factor complex | spindle | intracellular organelle | nuclear body | carboxy-terminal domain protein kinase complex | protein-containing complex | PML body | nucleoplasm | chromatin | nuclear cyclin-dependent protein kinase holoenzyme complex | transferase complex | microtubule cytoskeleton | serine/threonine protein kinase complex | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | cyclin-dependent protein kinase holoenzyme complex | cytoskeleton | intracellular
