QuickView for RBR-2;jsessionid=D75B3EBA8F2B27F2523007FA3911E340;jsessionid=6582004E436FCFFD50E63C6C81E2B5FB (gene)

Gene Symbol:

KDM5B Homo sapiens

Full name:

lysine demethylase 5B

Synonyms:

CT31, JARID1B, PLU-1, PLU1, PPP1R98, PUT1, RBBP2H1A, RBP2-H1, lysine-specific demethylase 5B, cancer/testis antigen 31, histone demethylase JARID1B, jumonji, AT rich interactive domain 1B, jumonji/ARID domain-containing protein 1B, lysine (K)-specific demethylase 5B, protein phosphatase 1, regulatory subunit 98, putative DNA/chromatin binding motif, retinoblastoma-binding protein 2 homolog 1, retinoblastoma-binding protein 2, homolog 1A

Genomic Location:

Chr 1: 200963155-201044172

Description:

This gene encodes a lysine-specific histone demethylase that belongs to the jumonji/ARID domain-containing family of histone demethylases. The encoded protein is capable of demethylating tri-, di- and monomethylated lysine 4 of histone H3. This protein plays a role in the transcriptional repression or certain tumor suppressor genes and is upregulat...

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This gene encodes a lysine-specific histone demethylase that belongs to the jumonji/ARID domain-containing family of histone demethylases. The encoded protein is capable of demethylating tri-, di- and monomethylated lysine 4 of histone H3. This protein plays a role in the transcriptional repression or certain tumor suppressor genes and is upregulated in certain cancer cells. This protein may also play a role in genome stability and DNA repair. Alternate splicing results in multiple transcript variants.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  C. elegans ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TTTGCAG_MIR518A2 ,  ATGTACA_MIR493 ,  GCACCTT_MIR18A_MIR18B ,  GACAGGG_MIR339

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-135 ,  Predicted Gene Targets for miR-18 ,  Predicted Gene Targets for miR-339 ,  Predicted Gene Targets for miR-137 ,  Predicted Gene Targets for miR-29 ,  Predicted Gene Targets for miR-376c ,  Predicted Gene Targets for miR-486 ,  Predicted Gene Targets for miR-493-5p

Cytogenetic Map:

1q32.1

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