QuickView for Tcfubf;jsessionid=E62AFA7AA3AC15CCA5308F9C4A77DC75 (gene)
- Gene Symbol:
- UBTF
Homo sapiens - Full name:
- upstream binding transcription factor, RNA polymerase I
- Synonyms:
- CONDBA, NOR-90, UBF, UBF-1, UBF1, UBF2, nucleolar transcription factor 1, 90-kDa nucleolus organizer region autoantigen, autoantigen NOR-90
- Genomic Location:
- Chr 17: 39637927-39653776
- Description:
-
This gene encodes a member of the HMG-box DNA-binding protein family. The encoded protein plays a critical role in ribosomal RNA transcription as a key component of the pre-initiation complex, mediating the recruitment of RNA polymerase I to rDNA promoter regions. The encoded protein may also play important roles in chromatin remodeling and pre-rRN...
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Danio rerio , Pan troglodytes , Canis lupus familiaris , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites: -
MYOD_Q6_01 , PAX4_04 , RYTTCCTG_ETS2_B , ZF5_01 , AACTGAC_MIR223 , NGFIC_01 , AP2GAMMA_01 , AP2ALPHA_01 , HEB_Q6 , GGGAGGRR_MAZ_Q6
- miRNA binding sites
(Source: TargetScan):
- Cytogenetic Map:
-
17q21.31
GO Molecular Function
sequence-specific DNA binding | transcription regulatory region DNA binding | RNA polymerase II transcription factor activity, sequence-specific DNA binding | core promoter binding | proximal promoter sequence-specific DNA binding | nucleic acid binding | RNA polymerase I regulatory region sequence-specific DNA binding | RNA polymerase I upstream control element sequence-specific DNA binding | chromatin binding | RNA polymerase I regulatory region DNA binding | DNA binding | sequence-specific double-stranded DNA binding | scaffold protein binding | organic cyclic compound binding | transcription regulatory region sequence-specific DNA binding | protein binding | double-stranded DNA binding | DNA-binding transcription factor activity | core promoter sequence-specific DNA binding | heterocyclic compound binding | RNA polymerase I CORE element sequence-specific DNA binding | RNA binding
GO Biological Process
RNA metabolic process | DNA-templated transcription, initiation | positive regulation of macromolecule biosynthetic process | regulation of transcription by RNA polymerase I | transcription initiation from RNA polymerase I promoter | RNA polymerase II transcription factor activity, sequence-specific DNA binding | positive regulation of cellular biosynthetic process | cellular process | positive regulation of nitrogen compound metabolic process | regulation of cellular process | regulation of metabolic process | organic cyclic compound metabolic process | RNA biosynthetic process | cellular aromatic compound metabolic process | cellular component organization | transcription by RNA polymerase I | cellular nitrogen compound biosynthetic process | protein-DNA complex assembly | cellular nitrogen compound metabolic process | positive regulation of RNA biosynthetic process | cellular component assembly | cellular biosynthetic process | regulation of nucleic acid-templated transcription | nitrogen compound metabolic process | regulation of signal transduction | regulation of gene expression | positive regulation of cellular metabolic process | regulation of nitrogen compound metabolic process | regulation of transcription by RNA polymerase II | biosynthetic process | aromatic compound biosynthetic process | cellular protein-containing complex assembly | DNA-templated transcriptional preinitiation complex assembly | regulation of cellular metabolic process | regulation of RNA metabolic process | DNA-templated transcription, termination | regulation of glucose mediated signaling pathway | protein-containing complex assembly | DNA-binding transcription factor activity | metabolic process | regulation of RNA biosynthetic process | RNA polymerase I transcriptional preinitiation complex assembly | nucleobase-containing compound metabolic process | organic substance metabolic process | gene expression | positive regulation of transcription by RNA polymerase I | transcription, DNA-templated | regulation of cell communication | regulation of transcription, DNA-templated | cellular macromolecule biosynthetic process | positive regulation of transcription, DNA-templated | positive regulation of nucleic acid-templated transcription | heterocycle metabolic process | positive regulation of metabolic process | cellular metabolic process | RNA polymerase I CORE element sequence-specific DNA binding | termination of RNA polymerase I transcription | regulation of signaling | positive regulation of gene expression | macromolecule metabolic process
GO Cellular Component
intracellular membrane-bounded organelle | fibrillar center | cell | nuclear lumen | nucleolus | intracellular organelle | nucleoplasm | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | intracellular
