QuickView for morula;jsessionid=E8CE20C138D27C42DCB211C76FCC714C;jsessionid=40CDC2231DD0155296A2912C1BB246E8;jsessionid=845E2721611C131D9AD7E6439C4F39A5;jsessionid=A79644F2E2313D827AF22133F085D149 (gene)

Gene Symbol:

ANAPC2 Homo sapiens

Full name:

anaphase promoting complex subunit 2

Synonyms:

APC2, anaphase-promoting complex subunit 2, cyclosome subunit 2

Genomic Location:

Chr 9: 139189057-139202878

Description:

A large protein complex, termed the anaphase-promoting complex (APC), or the cyclosome, promotes metaphase-anaphase transition by ubiquitinating its specific substrates such as mitotic cyclins and anaphase inhibitor, which are subsequently degraded by the 26S proteasome. Biochemical studies have shown that the vertebrate APC contains eight subunits...

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A large protein complex, termed the anaphase-promoting complex (APC), or the cyclosome, promotes metaphase-anaphase transition by ubiquitinating its specific substrates such as mitotic cyclins and anaphase inhibitor, which are subsequently degraded by the 26S proteasome. Biochemical studies have shown that the vertebrate APC contains eight subunits. The composition of the APC is highly conserved in organisms from yeast to humans. The product of this gene is a component of the complex and shares sequence similarity with a recently identified family of proteins called cullins, which may also be involved in ubiquitin-mediated degradation.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Saccharomyces cerevisiae ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CMYB_01 ,  CREB_02

Cytogenetic Map:

9q34.3

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