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    Aim: Intracranial aneurysm is often asymptomatic until the time of rupture. Elevated homocysteine is reported in vascular diseases. Identifying early events in homocysteine metabolism through methylation map genes may prevent fatality. Materials & methods: In the present study, we investigated the role of variants in methylation map genes in ethnically matched 480 individuals that can influence the homocysteine levels and promote development of aneurysm. Results: The study demonstrates that the genetic variants in folate cycle and methionine cycle genes such as MTHFR, MTRR, MTR, BHMT and DNMT1 are associated with the risk of aneurysm. Conclusion: The associated allelic variants in these genes have functional relevance and are predictive of decreased expression indicative of altered methylation levels that may result in elevated homocysteine.


    Chathathayil Mohammedali Shafeeque, Sanish Sathyan, Koramannil Radha Saradalekshmi, Sasi Premkumar, Jacob P Allapatt, Moinak Banerjee. Methylation map genes can be critical in determining the methylome of intracranial aneurysm patients. Epigenomics. 2020 May;12(10):859-871

    PMID: 32266834

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