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QuickView for 5-oxoproline (compound)

Summary
General Info

PubChem

PubChem Compound 439685

Name:	Pyrrolidonecarboxylic Acid
PubChem Compound ID:	439685
Description:	A cyclized derivative of L-GLUTAMIC ACID. Elevated blood levels may be associated with problems of GLUTAMINE or GLUTATHIONE metabolism.
Molecular formula:	C₅H₇NO₃
Molecular weight:	129.114 g/mol
Synonyms:	C02237; D-Pyroglutamic acid; (2R)-5-oxopyrrolidine-2-carboxylic acid; 4042-36-8; D-5-Pyrrolidone-2-carboxylic acid; 5-Oxo-D-proline; CHEBI:16924

DrugBank

Identification

Name:	Pyrrolidonecarboxylic Acid
Name (isomeric):	DB03088
Drug Type:	small molecule
Description:	A cyclized derivative of L-GLUTAMIC ACID. Elevated blood levels may be associated with problems of GLUTAMINE or GLUTATHIONE metabolism.
CAS number:	98-79-3

Targets

Vascular endothelial growth factor A

Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis, and induces permeabilization of blood vessels. Binds to the VEGFR1/Flt-1 and VEGFR2/Kdr receptors, heparan sulfate and heparin. Neuropilin-1 binds isoforms VEGF-165 and VEGF-145

UniProt ID:

P15692

Gene:

VEGFA

Actions:

unknown

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
View Article

Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34.
View Article

Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
View Article

Pancreatic alpha-amylase

Endohydrolysis of 1,4-alpha-D-glucosidic linkages in oligosaccharides and polysaccharides

UniProt ID:	P04746
Gene:	AMY2A
Actions:	unknown

Ig lambda-1 chain C regions

UniProt ID:

P0CG04

Gene:

IGLC1

Actions:

unknown

References:

Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
View Article

RNASE4 protein

UniProt ID:	Q53X86
Gene:	RNASE4
Actions:	unknown

Ig lambda chain V-II region MGC

UniProt ID:	P01709
Actions:	unknown

Trefoil factor 2

UniProt ID:

Q03403

Gene:

TFF2

Actions:

unknown

References:

Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
View Article

Cytochrome c2

Cytochrome c2 is found mainly in purple, non-sulfur, photosynthetic bacteria where it functions as the electron donor to the oxidized bacteriochlorophyll in the photophosphorylation pathway. However, it may also have a role in the respiratory chain and is found in some non-photosynthetic bacteria

UniProt ID:	P00091
Gene:	cycA
Actions:	unknown

Disintegrin and metalloproteinase domain-containing protein 28

May play a role in the adhesive and proteolytic events that occur during lymphocyte emigration or may function in ectodomain shedding of lymphocyte surface target proteins, such as FASL and CD40L. May be involved in sperm maturation

UniProt ID:

Q9UKQ2

Gene:

ADAM28

Actions:

unknown

References:

Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
View Article

Glycoside hydrolase

UniProt ID:	Q7SIE2
Actions:	unknown

Dissimilatory copper-containing nitrite reductase

UniProt ID:	O68601
Gene:	nir
Actions:	unknown

Glycoside hydrolase

UniProt ID:	Q7SIE3
Actions:	unknown

Keratin-associated protein 5-2

UniProt ID:

Q701N4

Gene:

KRTAP5-2

Actions:

unknown

References:

Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
View Article

Orexin

UniProt ID:

O43612

Gene:

HCRT

Actions:

unknown

References:

Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
View Article

Small inducible cytokine A8

Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils. May play a role in neoplasia and inflammatory host responses. This protein can bind heparin. The processed form MCP-2(6-76) does not show monocyte chemotactic activity, but inhibits the chemotactic effect most predominantly of CCL7, and also of CCL2 and CCL5 and CCL8

UniProt ID:	P80075
Gene:	CCL8
Actions:	unknown

Cytochrome c'

Cytochrome c' is the most widely occurring bacterial c- type cytochrome. Cytochromes c' are high-spin proteins and the heme has no sixth ligand. Their exact function is not known

UniProt ID:	P00138
Actions:	unknown

Alpha-amylase 2B

UniProt ID:

P19961

Gene:

AMY2B

Actions:

unknown

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
View Article

Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34.
View Article

Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
View Article

Angiogenin

May function as a tRNA-specific ribonuclease that binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus, thereby promoting the endothelial invasiveness necessary for blood vessel formation. Angiogenin induces vascularization of normal and malignant tissues. Abolishes protein synthesis by specifically hydrolyzing cellular tRNAs

UniProt ID:

P03950

Gene:

ANG

Actions:

unknown

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
View Article

Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34.
View Article

Chondroitinase B

Cleaves the glycosaminoglycan, dermatan sulfate

UniProt ID:

Q46079

Gene:

cslB

Actions:

unknown

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
View Article

Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34.
View Article

Salivary alpha-amylase

Endohydrolysis of 1,4-alpha-D-glucosidic linkages in oligosaccharides and polysaccharides

UniProt ID:

P04745

Gene:

AMY1A

Actions:

unknown

References:

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
View Article

Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34.
View Article

Enzymes

Pancreatic alpha-amylase

Endohydrolysis of 1,4-alpha-D-glucosidic linkages in oligosaccharides and polysaccharides

UniProt ID:	P04746
Gene:	AMY2A

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