Name: | Acepromazine |
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PubChem Compound ID: | 5476753 |
Description: | A phenothiazine that is used in the treatment of PSYCHOSES. |
Molecular formula: | C23H26N2O5S |
Molecular weight: | 442.529 g/mol |
Synonyms: |
Acepromazine hydrogen maleate; 61-00-7; Ethanone, 1-[10-[3- (dimethylamino)propyl]-10H-phenothiazin-2-yl]-, (Z)-2-butenedioate (1:1); 2664-15-5; Plegicil; Phenothiazine, 2-acetyl-10-[3-(dimethylamino)propyl]-, maleate; Notensil maleate; Pregicil; Notensil; NSC264522.
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Name: | Acepromazine |
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Name (isomeric): | DB01614 |
Drug Type: | small molecule |
Description: | A phenothiazine that is used in the treatment of PSYCHOSES. |
Synonyms: |
10-(3-dimethylaminopropyl)phenothiazin-3-yl methyl ketone; Acetylpromazine; 10-(3-dimethylaminopropyl)phenothiazine-3-ethylone; ACP
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Brand: | Atravet, Acezine 2 |
Category: | Sedatives and Hypnotics, Dopamine Antagonists, Antipsychotic Agents |
CAS number: | 61-00-7 |
Indication: | Acepromazine was first used in humans in the 1950s as an antipsychotic agent. It is now rarely used in humans. Acepromazine is frequently used in animals as a sedative and antiemetic. Its principal value is in quietening and calming anxious animals. |
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Pharmacology: |
Acepromazine is one of the phenothiazine derivative psychotropic drugs. Acepromazine has actions at all levels of the central nervous system-primarily at subcortical levels-as well as on multiple organ systems. Acepromazine has strong antiadrenergic and weaker peripheral anticholinergic activity; ganglionic blocking action is relatively slight. It ...
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Mechanism of Action: |
Acepromazine acts as an antagonist (blocking agent) on different postsysnaptic receptors -on dopaminergic-receptors (subtypes D1, D2, D3 and D4 - different antipsychotic properties on productive and unproductive symptoms), on serotonergic-receptors (5-HT1 and 5-HT2, with anxiolytic, antidepressive and antiaggressive properties as well as an attenua...
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Half Life: | 3 hours in horses. |
Toxicity: | Agitation, coma, convulsions, difficulty breathing, difficulty swallowing, dry mouth, extreme sleepiness, fever, intestinal blockage, irregular heart rate, low blood pressure, restlessness |
Affected organisms: | Humans and other mammals |
Food interaction: |
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