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QuickView for Acepromazine (compound)


PubChem
Name: Acepromazine
PubChem Compound ID: 5476753
Description: A phenothiazine that is used in the treatment of PSYCHOSES.
Molecular formula: C23H26N2O5S
Molecular weight: 442.529 g/mol
Synonyms:
Acepromazine hydrogen maleate; 61-00-7; Ethanone, 1-[10-[3- (dimethylamino)propyl]-10H-phenothiazin-2-yl]-, (Z)-2-butenedioate (1:1); 2664-15-5; Plegicil; Phenothiazine, 2-acetyl-10-[3-(dimethylamino)propyl]-, maleate; Notensil maleate; Pregicil; Notensil; NSC264522.
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DrugBank
Identification
Name: Acepromazine
Name (isomeric): DB01614
Drug Type: small molecule
Description: A phenothiazine that is used in the treatment of PSYCHOSES.
Synonyms:
10-(3-dimethylaminopropyl)phenothiazin-3-yl methyl ketone; Acetylpromazine; 10-(3-dimethylaminopropyl)phenothiazine-3-ethylone; ACP
Brand: Atravet, Acezine 2
Category: Sedatives and Hypnotics, Dopamine Antagonists, Antipsychotic Agents
CAS number: 61-00-7
Pharmacology
Indication: Acepromazine was first used in humans in the 1950s as an antipsychotic agent. It is now rarely used in humans. Acepromazine is frequently used in animals as a sedative and antiemetic. Its principal value is in quietening and calming anxious animals.
Pharmacology:
Acepromazine is one of the phenothiazine derivative psychotropic drugs. Acepromazine has actions at all levels of the central nervous system-primarily at subcortical levels-as well as on multiple organ systems. Acepromazine has strong antiadrenergic and weaker peripheral anticholinergic activity; ganglionic blocking action is relatively slight. It ...
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Mechanism of Action:
Acepromazine acts as an antagonist (blocking agent) on different postsysnaptic receptors -on dopaminergic-receptors (subtypes D1, D2, D3 and D4 - different antipsychotic properties on productive and unproductive symptoms), on serotonergic-receptors (5-HT1 and 5-HT2, with anxiolytic, antidepressive and antiaggressive properties as well as an attenua...
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Half Life: 3 hours in horses.
Toxicity: Agitation, coma, convulsions, difficulty breathing, difficulty swallowing, dry mouth, extreme sleepiness, fever, intestinal blockage, irregular heart rate, low blood pressure, restlessness
Affected organisms: Humans and other mammals
Interactions
Food interaction:
Avoid alcohol
Take with food to reduce irritation
Drug interaction:
DonepezilPossible antagonism of action
GalantaminePossible antagonism of action

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