QuickView for Bendroflumethiazide (compound)

Bendroflumetiazide [DCIT]; NINDS_000274; 3,4-Dihydro-3-(phenylmethyl)-6-(trifluoromethyl)-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide; FT 81; Spectrum2_001524; BHFT; Nikion; Plusuril; Relan beta; Spectrum_001386.
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Bendroflumetiazide [DCIT]; NINDS_000274; 3,4-Dihydro-3-(phenylmethyl)-6-(trifluoromethyl)-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide; FT 81; Spectrum2_001524; BHFT; Nikion; Plusuril; Relan beta; Spectrum_001386; KBio1_000274; KBio3_002536; Salural; Bendroflumethiazide (JAN/USP); KBio2_004434; SPBio_002827; Rauzide; Orsile; Sodiuretic; Salures; 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 3,4-dihydro-3-(phenylmethyl)-6-(trifluoromethyl)-, 1,1-dioxide; Pluryl; Sinesalin; Bendroflumethiazide [INN]; 4-27-00-08041 (Beilstein Handbook Reference); Be 724-A; Thiazidico; Neo-naclex; Benzhydroflumethiazide; Spectrum3_001558; Bendroflumethiazidum [INN-Latin]; SPBio_001308; BRN 0373316; Bendroflumethiazide; Bendroflumetiazida [INN-Spanish]; Niagaril; Pluryle; Bristuric; C07758; Prestwick1_000784; Naturetin (TN); Flumesil; FT 8; 3-Benzyl-3,4-dihydro-6-(trifluoromethyl)-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide; Urlea; D00650; KBio2_001866; Benzylhydroflumethiazide; Centyl; Benzylrodiuran; BENDROFUMETHIAZIDE; Repicin; Spectrum4_000774; Bentride; Prestwick_992; KBioGR_001188; HSDB 3293; KBioSS_001866; UNM000000601501; 3-Benzyl-6-trifluoromethyl-7-sulfamoyl-3,4-dihydro-1,2,4-benzothiadiazine, 1,1-dioxide; Neo-rontyl; Aprinox; Prestwick0_000784; KBio2_007002; Benuron; Livesan; MLS000028558; Bendrofluazide; EINECS 200-800-1; Poliuron; DivK1c_000274; Naturetin; 73-48-3; 6-Trifluoromethyl-3-benzyl-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine, 1,1-dioxide; Intolex; Berkozide; SMR000058802; BL H368; Rautrax N; 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 3-benzyl-3,4-dihydro-6-(trifluoromethyl)-, 1,1-dioxide; Bristuron; nchembio747-comp20; Corzide
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Bendrofluazide; Benzhydroflumethiazide; Bendroflumethiazidum [INN-Latin]; BHFT; Benzydroflumethiazide; Bendroflumetiazida [INN-Spanish]; Bendroflumethazide; Benzylhydroflumethiazide; Bendrofumethiazide

Bendroflumethiazide, a thiazide diuretic, removes excess water from the body by increasing how often you urinate (pass water) and also widens the blood vessels which helps to reduce blood pressure. It inhibits Na⁺/Cl^- reabsorption from the distal convoluted tubules in the kidneys. Thiazides also cause loss of potassium and an ...
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Bendroflumethiazide, a thiazide diuretic, removes excess water from the body by increasing how often you urinate (pass water) and also widens the blood vessels which helps to reduce blood pressure. It inhibits Na⁺/Cl^- reabsorption from the distal convoluted tubules in the kidneys. Thiazides also cause loss of potassium and an increase in serum uric acid. Thiazides are often used to treat hypertension, but their hypotensive effects are not necessarily due to their diuretic activity. Thiazides have been shown to prevent hypertension-related morbidity and mortality although the mechanism is not fully understood. Thiazides cause vasodilation by activating calcium-activated potassium channels (large conductance) in vascular smooth muscles and inhibiting various carbonic anhydrases in vascular tissue.
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As a diuretic, bendroflumethiazide inhibits active chloride reabsorption at the early distal tubule via the Na-Cl cotransporter, resulting in an increase in the excretion of sodium, chloride, and water. Thiazides like bendroflumethiazide also inhibit sodium ion transport across the renal tubular epithelium through binding to the thiazide sensitive ...
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As a diuretic, bendroflumethiazide inhibits active chloride reabsorption at the early distal tubule via the Na-Cl cotransporter, resulting in an increase in the excretion of sodium, chloride, and water. Thiazides like bendroflumethiazide also inhibit sodium ion transport across the renal tubular epithelium through binding to the thiazide sensitive sodium-chloride transporter. This results in an increase in potassium excretion via the sodium-potassium exchange mechanism. The antihypertensive mechanism of bendroflumethiazide is less well understood although it may be mediated through its action on carbonic anhydrases in the smooth muscle or through its action on the large-conductance calcium-activated potassium (KCa) channel, also found in the smooth muscle.
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