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QuickView for Deslanoside (compound)

Name: Deslanoside
PubChem Compound ID: 11766385
Description: Deacetyllanatoside C. A cardiotonic glycoside from the leaves of Digitalis lanata.
Molecular formula: C47H74O19
Molecular weight: 943.079 g/mol
Name: Deslanoside
Name (isomeric): DB01078
Drug Type: small molecule
Description: Deacetyllanatoside C. A cardiotonic glycoside from the leaves of Digitalis lanata.
Brand: Cedilanid-d, Deacetyllanatoside C
Category: Cardiotonic Agents, Enzyme Inhibitors, Anti-Arrhythmia Agents
CAS number: 17598-65-1
Indication: For the treatment and management of Congestive cardiac insufficiency, arrhythmias and heart failure.
Pharmacology: Deslanoside is a cardiac glycoside used to treat congestive heart failure and supraventricular arrhythmias due to reentry mechanisms, and to control ventricular rate in the treatment of chronic atrial fibrillation.
Mechanism of Action:
Deslanoside inhibits the Na-K-ATPase membrane pump, resulting in an increase in intracellular sodium and calcium concentrations. Increased intracellular concentrations of calcium may promote activation of contractile proteins (e.g., actin, myosin). Deslanoside also acts on the electrical activity of the heart, increasing the slope of phase 4 depola...
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Absorption: Little absorption from the gastrointestinal tract (40%).
Protein binding: 20%
Half Life: 36 hours
Toxicity: Symptoms of overdose include ventricular tachycardia, ventricular fibrillation, progressive bradyarrhythmias, or heart block.
Affected organisms: Humans and other mammals
Drug interaction:
Ethacrynic acidPossible electrolyte variations and arrhythmias
HydrochlorothiazidePossible electrolyte variations and arrhythmias
MetolazonePossible electrolyte variations and arrhythmias
ChlorthalidonePossible electrolyte variations and arrhythmias
FurosemidePossible electrolyte variations and arrhythmias
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