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Name: Chlorthalidone
PubChem Compound ID: 2732
Description: A benzenesulfonamide-phthalimidine that tautomerizes to a BENZOPHENONES form. It is considered a thiazide-like diuretic.
Molecular formula: C14H11ClN2O4S
Molecular weight: 338.767 g/mol
Hygroton; Natriuran; Thalitone; (+-)-Chlorthalidone; 1-Oxo-3-(3-sulfamyl-4-chlorophenyl)-3-hydroxyisoindoline; Chlortalidonum [INN-Latin]; Isoren; D00272; 5-22-07-00602 (Beilstein Handbook Reference); G-33182.
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Name: Chlorthalidone
Name (isomeric): DB00310
Drug Type: small molecule
Description: A benzenesulfonamide-phthalimidine that tautomerizes to a BENZOPHENONES form. It is considered a thiazide-like diuretic.
Clodronic Acid; Chlorphthalidone; Chlorphthalidolone; Chlorothalidone; Chlorthalidon; Chlortalidone
Brand: Isoren, Zambesil, Igroton, Higroton, Natriuran, Hydro-Long, Oradil, Renon, Tenoretic, Hygroton, Thalitone, Phthalamudine, Phthalamodine, Saluretin
Brand name mixture: Tenoretic(chlorthalidone + atenolol)
Category: Sodium Chloride Symporter Inhibitors, Diuretics, Antihypertensive Agents
CAS number: 77-36-1
Indication: For management of hypertension either as the sole therapeutic agent or to enhance the effect of other antihypertensive drugs in the more severe forms of hypertension.
Pharmacology: Chlorthalidone, a monosulfonamyl diuretic, differs form other thiazide diuretics in that a double ring system is incorporated into its structure. Chlorthalidone is used alone or with atenolol in the management of hypertension and edema.
Mechanism of Action: Chlorthalidone inhibits sodium ion transport across the renal tubular epithelium in the cortical diluting segment of the ascending limb of the loop of Henle. By increasing the delivery of sodium to the distal renal tubule, Chlorthalidone indirectly increases potassium excretion via the sodium-potassium exchange mechanism.
Absorption: Absorbed relatively rapidly after oral administration.
Protein binding: High (75% [58% to albumin])
Biotransformation: Liver
Route of elimination: The major portion of the drug is excreted unchanged by the kidneys.
Half Life: 40 hours
Toxicity: Symptoms of overdose include nausea, weakness, dizziness and disturbances of electrolyte balance.
Affected organisms: Humans and other mammals
Food interaction:
Take with food (increases availability).
Drug interaction:
DigitoxinPossible electrolyte variations and arrhythmias
DeslanosidePossible electrolyte variations and arrhythmias
TenoxicamTenoxicam may antagonize the blood pressure lowering effect of Chlorthalidone. Monitor for changes in the therapeutic effect of Chlorthalidone if Tenoxicam is initiated, discontinued or dose changed.
LithiumThe thiazide diuretic, chlorthalidone, may increase serum levels of lithium.
DofetilideIncreased risk of cardiotoxicity and arrythmias
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