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QuickView for Cyclacillin (compound)

Name: Cyclacillin
PubChem Compound ID: 19003
Description: A cyclohexylamido analog of PENICILLANIC ACID.
Molecular formula: C15H23N3O4S
Molecular weight: 341.427 g/mol
AIDS-007678; Cyclapen-W; Vastcillin; Ciclacillin (JP15); CAS-3485-14-1; C12766; Syngacillin; NSC 88789; 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-(1-aminocyclohexanecarboxamido)-3,3-dimethyl-7-oxo- (8CI); Ciclacilina [INN-Spanish].
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Name: Cyclacillin
Name (isomeric): DB01000
Drug Type: small molecule
Description: A cyclohexylamido analog of PENICILLANIC ACID.
Ciclacilina [INN-Spanish]; Ciclacillum; Ciclacilline [INN-French]; Ciclacillin; Aminocyclohexylpenicillin; Ciclacillinum [INN-Latin]
Brand: Vipicil, Cyclapen, Calthor, Orfilina, Bastcillin, Vastcillin, Wyvital, Ultracillin, Syngacillin, Cyclapen-W, Citosarin
Category: Anti-Bacterial Agents, Penicillins
CAS number: 3485-14-1
Indication: For the treatment of bacterial infections caused by susceptible organisms.
Cyclacillin, a penicillin, is a cyclohexylamido analog of penicillanic acid. Cyclacillin is more resistant to beta-lactamase hydrolysis than ampicillin, is much better absorbed when given by mouth and, as a result, the levels reached in the blood and in the urine are considerably higher than those obtained with the same dose of ampicillin. Cyclacil...
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Mechanism of Action: The bactericidal activity of cyclacillin results from the inhibition of cell wall synthesis via affinity for penicillin-binding proteins (PBPs). Cyclacillin is stable in the presence of a variety of b-lactamases, including penicillinases and some cephalosporinases.
Absorption: Moderately absorbed.
Toxicity: Symptoms of overdose include severe diarrhea, nausea and vomiting.
Affected organisms: Enteric bacteria and other eubacteria
Drug interaction:
Ethinyl EstradiolThis anti-infectious agent could decrease the effect of the oral contraceptive
DoxycyclinePossible antagonism of action
DemeclocyclinePossible antagonism of action
MinocyclinePossible antagonism of action
TetracyclinePossible antagonism of action