Name: | Cyclacillin |
---|---|
PubChem Compound ID: | 19003 |
Description: | A cyclohexylamido analog of PENICILLANIC ACID. |
Molecular formula: | C15H23N3O4S |
Molecular weight: | 341.427 g/mol |
Synonyms: |
AIDS-007678; Cyclapen-W; Vastcillin; Ciclacillin (JP15); CAS-3485-14-1; C12766; Syngacillin; NSC 88789; 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-(1-aminocyclohexanecarboxamido)-3,3-dimethyl-7-oxo- (8CI); Ciclacilina [INN-Spanish].
show more » |
Name: | Cyclacillin |
---|---|
Name (isomeric): | DB01000 |
Drug Type: | small molecule |
Description: | A cyclohexylamido analog of PENICILLANIC ACID. |
Synonyms: |
Ciclacilina [INN-Spanish]; Ciclacillum; Ciclacilline [INN-French]; Ciclacillin; Aminocyclohexylpenicillin; Ciclacillinum [INN-Latin]
|
Brand: | Vipicil, Cyclapen, Calthor, Orfilina, Bastcillin, Vastcillin, Wyvital, Ultracillin, Syngacillin, Cyclapen-W, Citosarin |
Category: | Anti-Bacterial Agents, Penicillins |
CAS number: | 3485-14-1 |
Indication: | For the treatment of bacterial infections caused by susceptible organisms. |
---|---|
Pharmacology: |
Cyclacillin, a penicillin, is a cyclohexylamido analog of penicillanic acid. Cyclacillin is more resistant to beta-lactamase hydrolysis than ampicillin, is much better absorbed when given by mouth and, as a result, the levels reached in the blood and in the urine are considerably higher than those obtained with the same dose of ampicillin. Cyclacil...
show more » |
Mechanism of Action: | The bactericidal activity of cyclacillin results from the inhibition of cell wall synthesis via affinity for penicillin-binding proteins (PBPs). Cyclacillin is stable in the presence of a variety of b-lactamases, including penicillinases and some cephalosporinases. |
Absorption: | Moderately absorbed. |
Toxicity: | Symptoms of overdose include severe diarrhea, nausea and vomiting. |
Affected organisms: | Enteric bacteria and other eubacteria |
Drug interaction: |
|
---|