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QuickView for Dicyclomine (compound)

Summary
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PubChem

PubChem Compound 3042

PubChem Compound 3042

Name:	Dicyclomine
PubChem Compound ID:	3042
Description:	A muscarinic antagonist used as an antispasmodic and in urinary incontinence. It has little effect on glandular secretion or the cardiovascular system. It does have some local anesthetic properties and is used in gastrointestinal, biliary, and urinary tract spasms.
Molecular formula:	C₁₉H₃₅NO₂
Molecular weight:	309.487 g/mol
Synonyms:	Diocyl; DivK1c_000162; (1,1'-Bicyclohexyl)-1-carboxylic acid, 2-(diethylamino)ethyl ester; Di-syntramine; .beta.-Diethylaminoethyl-1-cyclohexylhexahydrobenzoate hydrochloride; Bentylol hydrochloride; SPBio_000440; Atumin; KBio2_003982; Kolantyl hydrochloride. show more » Diocyl; DivK1c_000162; (1,1'-Bicyclohexyl)-1-carboxylic acid, 2-(diethylamino)ethyl ester; Di-syntramine; .beta.-Diethylaminoethyl-1-cyclohexylhexahydrobenzoate hydrochloride; Bentylol hydrochloride; SPBio_000440; Atumin; KBio2_003982; Kolantyl hydrochloride; Prestwick0_000048; Spectrum_000934; GU8471000; [1,1'-Bicyclohexyl]-1-carboxylic acid, 2- (diethylamino)ethyl ester, hydrochloride; Prestwick1_000048; Wyovin; NCGC00016300-01; Dicycloverin hydrochloride; Dicyclomine hydrochloride; Merbentyl; Bentylol; (BICYCLOHEXYL)-1-CARBOXYLIC ACID, 2-(DIETHYLAMINO)ETHYL ESTER, HYDROCHLORIDE; KBio2_001414; Spectrum3_000388; Cyclohexanecarboxylic acid, 1-cyclohexyl-, 2-(diethylamino)ethyl ester; CAS-67-92-5; KBioSS_001414; [Bicyclohexyl]-1-carboxylic acid, 2- (diethylamino)ethyl ester hydrochloride; Dicycloverine; Wyovin hydrochloride; 1-Cyclohexylcyclohexanecarboxylic acid 2-(diethylamino)ethyl ester; KBio3_001395; Oxityl-P; Procyclomin; KBioGR_001057; .beta.-Diethylaminoethyl 1-cyclohexylcyclohexanecarboxylate hydrochloride; Bis(cyclohexyl)carboxylic acid diethylaminoethyl ester hydrochloride; (Bicyclohexyl)-1-carboxylic acid, 2-(diethylamino)ethyl ester; J.L. 998; Mamiesan; NSC404381; [1,1'-Bicyclohexyl]-1-carboxylic acid, 2-(diethylamino)ethyl ester; Diocyl hydrochloride; Bentomine; HSDB 3058; Dicycloverinum [INN-Latin]; Dicyclomine; KBio2_006550; Bentyl hydrochloride; NINDS_000162; Dicicloverina [INN-Spanish]; Diethylaminocarbethoxybicyclohexyl hydrochloride; 104959-55-9; SPBio_002096; NCGC00015368-01; Dyspas; KBio1_000162; 67-92-5; Lopac-D-7909; EINECS 201-009-4; Spectrum2_000590; Dicycloverine hydrochloride; Dicycloverin; 77-19-0; Spectrum4_000509; C06951; Sawamin show less «

DrugBank

Identification

Name:	Dicyclomine
Name (isomeric):	DB00804
Drug Type:	small molecule
Description:	A muscarinic antagonist used as an antispasmodic and in urinary incontinence. It has little effect on glandular secretion or the cardiovascular system. It does have some local anesthetic properties and is used in gastrointestinal, biliary, and urinary tract spasms.
Brand:	Dyspas, Bentyl, Dicyclomine Hydrochloride, Di-Syntramine, Diocyl Hydrochloride, Diethylaminocarbethoxybicyclohexyl Hydrochloride, Merbentyl, Dicicloverina [INN-Spanish], Dicycloverine Hydrochloride, Dicycloverine, Bentyl Hydrochloride, Mamiesan, Bentomine, Dicycloverin, Dicyclomine Hcl, Diocyl, Bentylol Hydrochloride, Dicycloverin Hydrochloride, Kolantyl Hydrochloride, Sawamin, Procyclomin, Spasmoban, Atumin, Oxityl-P, Dicycloverinum [INN-Latin], Wyovin Hydrochloride, Formulex, Bentylol, Wyovin
Category:	Muscarinic Antagonists, Parasympatholytics, Anticholinergic Agents, Antispasmodics, Antimuscarinics
CAS number:	77-19-0

Pharmacology

Indication:	For the treatment of functional bowel/irritable bowel syndrome including Colicky abdominal pain; diverticulitis
Pharmacology:	Dicyclomine is an anticholinergic drug, a medication that reduces the effect of acetylcholine, a chemical released from nerves that stimulates muscles, by blocking the receptors for acetylcholine on smooth muscle (a type of muscle). It also has a direct relaxing effect on smooth muscle. Dicyclomine is used to treat or prevent spasm in the muscles o... show more » Dicyclomine is an anticholinergic drug, a medication that reduces the effect of acetylcholine, a chemical released from nerves that stimulates muscles, by blocking the receptors for acetylcholine on smooth muscle (a type of muscle). It also has a direct relaxing effect on smooth muscle. Dicyclomine is used to treat or prevent spasm in the muscles of the gastrointestinal tract in the irritable bowel syndrome. In addition, Dicyclomine inhibits gastrointestinal propulsive motility and decreases gastric acid secretion and controls excessive pharyngeal, tracheal and bronchial secretions. show less «
Mechanism of Action:	Action is achieved via a dual mechanism: (1) a specific anticholinergic effect (antimuscarinic) at the acetylcholine-receptor sites and (2) a direct effect upon smooth muscle (musculotropic).
Protein binding:	>99%
Route of elimination:	The principal route of elimination is via the urine (79.5% of the dose). Excretion also occurs in the feces, but to a lesser extent (8.4%).
Affected organisms:	Humans and other mammals

Interactions

Food interaction:

Avoid alcohol.

Take this medication 30 minutes before meals.

Drug interaction:

Trimethobenzamide	Trimethobenzamide and Dicyclomine, two anticholinergics, may cause additive anticholinergic effects and enhance their adverse/toxic effects. Monitor for enhanced anticholinergic effects.
Tacrine	The therapeutic effects of the central acetylcholinesterase inhibitor, Tacrine, and/or the anticholinergic, Dicyclomine, may be reduced due to antagonism. The interaction may be beneficial when the anticholinergic action is a side effect. Monitor for decreased efficacy of both agents.
Donepezil	Possible antagonism of action
Trospium	Trospium and Dicyclomine, two anticholinergics, may cause additive anticholinergic effects and enhanced adverse/toxic effects. Monitor for enhanced anticholinergic effects.
Rivastigmine	Possible antagonism of action

Targets

Muscarinic acetylcholine receptor M1

Muscarinic acetylcholine receptor M2

Enzymes

Cytochrome P450 1A1