QuickView for FEOM2 (gene)

Gene Symbol:

PHOX2A Homo sapiens

Full name:

paired like homeobox 2a

Synonyms:

ARIX, CFEOM2, FEOM2, NCAM2, PMX2A, paired mesoderm homeobox protein 2A, ARIX1 homeodomain protein, aristaless homeobox homolog, aristaless homeobox protein homolog, arix homeodomain protein, paired-like homeobox 2A

Genomic Location:

Chr 11: 71627769-71632852

Description:

The protein encoded by this gene contains a paired-like homeodomain most similar to that of the Drosophila aristaless gene product. The encoded protein plays a central role in development of the autonomic nervous system. It regulates the expression of tyrosine hydroxylase and dopamine beta-hydroxylase, two catecholaminergic biosynthetic enzymes ess...

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The protein encoded by this gene contains a paired-like homeodomain most similar to that of the Drosophila aristaless gene product. The encoded protein plays a central role in development of the autonomic nervous system. It regulates the expression of tyrosine hydroxylase and dopamine beta-hydroxylase, two catecholaminergic biosynthetic enzymes essential for the differentiation and maintenance of the noradrenergic neurotransmitter phenotype. The encoded protein has also been shown to regulate transcription of the alpha3 nicotinic acetylcholine receptor gene. Mutations in this gene have been associated with autosomal recessive congenital fibrosis of the extraocular muscles.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Canis lupus familiaris ,  Bos taurus ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

NKX25_01 ,  GATA_Q6 ,  GATA_C ,  ZF5_01 ,  CAGGTG_E12_Q6 ,  SP1_Q4_01 ,  WYAAANNRNNNGCG_UNKNOWN ,  SP3_Q3 ,  GGGCGGR_SP1_Q6 ,  SP1_Q6 ,  HEN1_02 ,  LXR_Q3 ,  SP1_Q6_01 ,  SP1_Q2_01

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Cytogenetic Map:

11q13.4

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