Name: | Phenoxybenzamine |
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PubChem Compound ID: | 4768 |
Description: | An alpha-adrenergic antagonist with long duration of action. It has been used to treat hypertension and as a peripheral vasodilator. |
Molecular formula: | C18H22ClNO |
Molecular weight: | 303.826 g/mol |
Synonyms: |
DivK1c_000800; N-(2-Chloroethyl)-N-(1-methyl-2-phenoxyethyl)benzenemethanamine hydrochloride; NSC37448; 59-96-1; N-Phenoxyisopropyl-N-benzyl-beta-chloroethylamine; KBio2_003426; 4-12-00-02204 (Beilstein Handbook Reference); Dibenzylene; Benzyl(2-chloroethyl)-(1-methyl-2-phenoxyethyl)amine; Dibenzyline.
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Name: | Phenoxybenzamine |
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Name (isomeric): | DB00925 |
Drug Type: | small molecule |
Description: | An alpha-adrenergic antagonist with long duration of action. It has been used to treat hypertension and as a peripheral vasodilator. |
Synonyms: |
Phenoxybenzamine Hcl; Phenoxybenzaminum [INN-Latin]; Fenossibenzamina [Dcit]; POB HCl; Phenoxybenzamine Hydrochloride; Fenoxibenzamina [INN-Spanish]
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Brand: | Dibenzyline Hydrochloride, Benzylyt, Dibenzyline, Dibenylin, Dibenyline, Bensylyt, Dibenzyran, Dibenzylene, Bensylyt Nen, Bensylyte |
Category: | Vasodilator Agents, Adrenergic alpha-Antagonists, Antihypertensive Agents |
CAS number: | 59-96-1 |
Indication: | For the treatment of phaeochromocytoma (malignant), benign prostatic hypertrophy and malignant essential hypertension. |
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Pharmacology: |
Phenoxybenzamine is indicated for the control of episodes of hypertension and sweating that occur with a disease called pheochromocytoma. If tachycardia is excessive, it may be necessary to use a beta-blocking agent concomitantly. Phenoxybenzamine is a long-acting, adrenergic, alpha-receptor blocking agent which can produce and maintain "chemical s...
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Mechanism of Action: | Phenoxybenzamine produces its therapeutic actions by blocking alpha receptors, leading to a muscle relaxation and a widening of the blood vessels. This widening of the blood vessels results in a lowering of blood pressure. |
Absorption: | Twenty to 30 percent of orally administered phenoxybenzamine appears to be absorbed in the active form. |
Half Life: | 24 hours |
Toxicity: | Symptoms of overdose are largely the result of block of the sympathetic nervous system and of the circulating epinephrine. They may include postural hypotension resulting in dizziness or fainting, tachycardia, particularly postural, vomiting; lethargy, and shock. |
Affected organisms: | Humans and other mammals |
Drug interaction: |
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