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QuickView for Phenoxybenzamine (compound)


PubChem
Name: Phenoxybenzamine
PubChem Compound ID: 4768
Description: An alpha-adrenergic antagonist with long duration of action. It has been used to treat hypertension and as a peripheral vasodilator.
Molecular formula: C18H22ClNO
Molecular weight: 303.826 g/mol
Synonyms:
DivK1c_000800; N-(2-Chloroethyl)-N-(1-methyl-2-phenoxyethyl)benzenemethanamine hydrochloride; NSC37448; 59-96-1; N-Phenoxyisopropyl-N-benzyl-beta-chloroethylamine; KBio2_003426; 4-12-00-02204 (Beilstein Handbook Reference); Dibenzylene; Benzyl(2-chloroethyl)-(1-methyl-2-phenoxyethyl)amine; Dibenzyline.
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DrugBank
Identification
Name: Phenoxybenzamine
Name (isomeric): DB00925
Drug Type: small molecule
Description: An alpha-adrenergic antagonist with long duration of action. It has been used to treat hypertension and as a peripheral vasodilator.
Synonyms:
Phenoxybenzamine Hcl; Phenoxybenzaminum [INN-Latin]; Fenossibenzamina [Dcit]; POB HCl; Phenoxybenzamine Hydrochloride; Fenoxibenzamina [INN-Spanish]
Brand: Dibenzyline Hydrochloride, Benzylyt, Dibenzyline, Dibenylin, Dibenyline, Bensylyt, Dibenzyran, Dibenzylene, Bensylyt Nen, Bensylyte
Category: Vasodilator Agents, Adrenergic alpha-Antagonists, Antihypertensive Agents
CAS number: 59-96-1
Pharmacology
Indication: For the treatment of phaeochromocytoma (malignant), benign prostatic hypertrophy and malignant essential hypertension.
Pharmacology:
Phenoxybenzamine is indicated for the control of episodes of hypertension and sweating that occur with a disease called pheochromocytoma. If tachycardia is excessive, it may be necessary to use a beta-blocking agent concomitantly. Phenoxybenzamine is a long-acting, adrenergic, alpha-receptor blocking agent which can produce and maintain "chemical s...
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Mechanism of Action: Phenoxybenzamine produces its therapeutic actions by blocking alpha receptors, leading to a muscle relaxation and a widening of the blood vessels. This widening of the blood vessels results in a lowering of blood pressure.
Absorption: Twenty to 30 percent of orally administered phenoxybenzamine appears to be absorbed in the active form.
Half Life: 24 hours
Toxicity: Symptoms of overdose are largely the result of block of the sympathetic nervous system and of the circulating epinephrine. They may include postural hypotension resulting in dizziness or fainting, tachycardia, particularly postural, vomiting; lethargy, and shock.
Affected organisms: Humans and other mammals
Interactions
Drug interaction:
TamsulosinConcomitant use of alpha1-adrenergic antagonists, Tamsulosin and Phenoxybenzamine, may result in additive antihypertensive effects. Combination therapy is not recommended.
VardenafilAdditive hypotensive effects of the PDE5 inhibitor, Vardenafil, and alpha1-blocker, Phenoxybenzamine, may occur. Monitor for hypotension during concomitant therapy.
TadalafilTadalafil may enhance the hypotensive effect of Phenoxybenzamine. Monitor for hypotension during concomitant therapy.
TreprostinilAdditive hypotensive effect. Monitor antihypertensive therapy during concomitant use.

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