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QuickView for bambuterol (compound)

Name: bambuterol
PubChem Compound ID: 11726467
Molecular formula: C18H29N3O5
Molecular weight: 367.44 g/mol
Name: bambuterol
Name (isomeric): DB01408
Drug Type: small molecule
Bambuterol hydrochloride
Brand: Bambec, Oxeol
Category: Tocolytic Agents, Adrenergic beta-Agonists, Sympathomimetics, Bronchodilator Agents
CAS number: 81732-46-9
Indication: For the prevention and reversal of bronchospasm in patients 12 years of age and older with asthma and reversible bronchospasm associated with bronchitis and emphysema.
Pharmacology: Bambuterol is a long acting beta2-adrenoceptor agonist used in the treatment of asthma. It is a prodrug of terbutaline. Bambuterol causes smooth muscle relaxation, resulting in dilation of bronchial passages.
Mechanism of Action:
The pharmacologic effects of bambuterol are at least in part attributable to stimulation through beta-adrenergic receptors (beta 2 receptors) of intracellular adenyl cyclase, the enzyme that catalyzes the conversion of adenosine triphosphate (ATP) to cyclic AMP. Increased cyclic AMP levels are associated with relaxation of bronchial smooth muscle a...
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Absorption: Bioavailability is 20% following oral administration.
Biotransformation: Hepatic, extensive. Further metabolized to terbutaline by plasma cholinesterase.
Half Life: 13 hours for bambuterol and 21 hours for the primary active metabolite terbutaline.
Affected organisms: Humans and other mammals