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PubChem
| Name: | Methyltestosterone |
|---|---|
| PubChem Compound ID: | 11869584 |
| Description: | A synthetic hormone used for androgen replacement therapy and as an hormonal antineoplastic agent (ANTINEOPLASTIC AGENTS, HORMONAL). |
| Molecular formula: | C20H30O2 |
| Molecular weight: | 302.451 g/mol |
| Synonyms: |
ZINC03881781
|
DrugBank
Identification
| Name: | Methyltestosterone |
|---|---|
| Name (isomeric): | DB06710 |
| Drug Type: | small molecule |
| Description: | A synthetic hormone used for androgen replacement therapy and as an hormonal antineoplastic agent (ANTINEOPLASTIC AGENTS, HORMONAL). |
| Brand: | Android, Virilon, Testred |
| Category: | Anabolic Agents, Hormone Replacement Agents, Androgens |
| CAS number: | 58-18-4 |
Pharmacology
| Indication: | Methyltestosterone is an anabolic steroid hormone used to treat men with a testosterone deficiency. It is also used in women to treat breast cancer, breast pain, swelling due to pregnancy, and with the addition of estrogen it can treat symptoms of menopause. |
|---|---|
| Pharmacology: |
Testosterone is a steroid hormone from the androgen group. Testosterone is primarily secreted from the testes of males. In females, it is produced in the ovaries, adrenal glands and by conversion of adrostenedione in the periphery. It is the principal male sex hormone and an anabolic steroid. In both males and females, it plays key roles in health ...
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| Mechanism of Action: |
The effects of testosterone in humans and other vertebrates occur by way of two main mechanisms: by activation of the androgen receptor (directly or as DHT), and by conversion to estradiol and activation of certain estrogen receptors. Free testosterone (T) is transported into the cytoplasm of target tissue cells, where it can bind to the androgen r...
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| Absorption: | The methyl group aids to increase oral bioavailability. |
| Protein binding: | 40% of testosterone in plasma is bound to sex hormone-binding globulin and 2% remains unbound and the rest is bound to albumin and other proteins. |
| Biotransformation: | Hepatic. Testosterone is metabolized to 17-keto steroids through two different pathways. The major active metabolites are estradiol and dihydrotestosterone (DHT). |
| Route of elimination: | 90% urine / 10% feces |
| Half Life: | 6-8 hours |
| Toxicity: | Side effects include amnesia, anxiety, discolored hair, dizziness, dry skin, hirsutism, hostility, impaired urination, paresthesia, penis disorder, peripheral edema, sweating, and vasodilation. |
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