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QuickView for Atropine (compound)
PubChem
| Name: | Atropine |
|---|---|
| PubChem Compound ID: | 154417 |
| Description: | An alkaloid, originally from Atropa belladonna, but found in other plants, mainly SOLANACEAE. |
| Molecular formula: | C17H23NO3 |
| Molecular weight: | 289.369 g/mol |
| Synonyms: |
L-Hyoscyamine; AIDS-012108; Scopolia extract (TN); Prestwick_273; Atropine; 55-48-1; Duboisine; 8-methyl-8-azabicyclo[3.2.1]oct-3-yl 3-hydroxy-2-phenylpropanoate; C02046; Hyoscyamine.
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DrugBank
Identification
| Name: | Atropine |
|---|---|
| Name (isomeric): | DB00424 |
| Drug Type: | small molecule |
| Description: | An alkaloid, originally from Atropa belladonna, but found in other plants, mainly SOLANACEAE. |
| Synonyms: |
Hyocyamine; L-Hyoscyamine; L-Tropine Tropate; L-Hyopscyamine; L-Atropine; L-Hyoscamine
|
| Brand: | Daturine, Scopolia Extract, Levsinex, Duretter, Levbid, Donnamar, Egazil, Buwecon, Egacene, Peptard, Symax, Anaspaz, Levsin, NuLev, Neoquess, Cystospaz, Duboisine, Gastrosed, OIN |
| Category: | Muscarinic Antagonists, Adjuvants, Anesthesia, Parasympatholytics, Mydriatics, Antiarrhythmic Agents, Antispasmodics, Anti-Arrhythmia Agents, Antimuscarinics, Bronchodilator Agents |
| CAS number: | 101-31-5 |
Pharmacology
| Indication: | For treatment of bladder spasms, peptic ulcer disease, diverticulitis, colic, irritable bowel syndrome, cystitis, and pancreatitis. Also used to treat certain heart conditions, to control the symptoms of Parkinson's disease and rhinitis. |
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| Pharmacology: | L-Hyoscyamine, the active optical isomer of atropine (dl-hyoscyamine), is a tertiary amine anticholinergic gastrointestinal agent. |
| Mechanism of Action: |
Hyoscyamine competes favorably with acetylcholine for binding at muscarinic receptors in the salivary, bronchial, and sweat glands as well as in the eye, heart, and gastrointestinal tract. The actions of hyoscyamine result in a reduction in salivary, bronchial, gastric and sweat gland secretions, mydriasis, cycloplegia, change in heart rate, contra...
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| Absorption: | Absorbed totally and completely by sublingual administration as well as oral administration. |
| Protein binding: | 50% |
| Biotransformation: | Hepatic |
| Half Life: | 2-3.5 hours |
| Toxicity: | Symptoms of overdose include headache, nausea, vomiting, blurred vision, dilated pupils, hot dry skin, dizziness, dryness of the mouth, difficulty in swallowing, and CNS stimulation. LD50=mg/kg(orally in rat) |
| Affected organisms: | Humans and other mammals |
Interactions
| Food interaction: |
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Targets
DrugBank
Identification
| Name: | Atropine |
|---|---|
| Name (isomeric): | DB00572 |
| Drug Type: | small molecule |
| Description: | An alkaloid, originally from Atropa belladonna, but found in other plants, mainly SOLANACEAE. |
| Synonyms: |
DL-Tropyl tropate; Atropin [German]; Atropina [Italian]; Atropine Sulfate; DL-Hyoscyamine
|
| Brand: | Atrosulf, Ocu-Tropine, I-Tropine, Atropisol, Homapin-5, Atropine Sulfate S.O.P., Troyl tropate, Atropin, Atropine Care, Atropine Sulfate Ansyr Plastic Syringe, Atropen, Atropin-flexiolen, Minims Atropine, Eyesules, Isopto Atropine, Homapin-10, Atropair, Atnaa, Atropinol, Isopto-atropine, Equipin, Tropine tropate |
| Brand name mixture: | Spascupreel Tablets(Aconitum + Agaricus + Atropine Sulfate + Chamomile + Citrullus Colocynthis + Copper Sulfate + Gelsemium Sempervirens + Magnesium Phosphate Dibasic + Passion Flower), Diban Cap(Atropine Sulfate + Attapulgite (Activated) + Hyoscyamine Sulfate + Opium + Pectin + Scopolamine Hydrobromide), Spascupreel Injeel Liq(Aconite + Atropin... show more » |
| Category: | Muscarinic Antagonists, Adjuvants, Anesthesia, Parasympatholytics, Mydriatics, Anti-Arrhythmia Agents, Bronchodilator Agents |
| CAS number: | 51-55-8 |
Pharmacology
| Indication: | For the treatment of poisoning by susceptible organophosphorous nerve agents having cholinesterase activity as well as organophosphorous or carbamate insecticides. |
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| Pharmacology: |
Atropine, a naturally occurring belladonna alkaloid, is a racemic mixture of equal parts of d- and l-hyoscyamine, whose activity is due almost entirely to the levo isomer of the drug. Atropine is commonly classified as an anticholinergic or antiparasympathetic (parasympatholytic) drug. More precisely, however, it is termed an antimuscarinic agent s...
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| Mechanism of Action: | Atropine binds to and inhibit muscarinic acetylcholine receptors, producing a wide range of anticholinergic effects. |
| Absorption: | Atropine is rapidly and well absorbed after intramuscular administration. Atropine disappears rapidly from the blood and is distributed throughout the various body tissues and fluids. |
| Protein binding: | The protein binding of atropine is 14 to 22% in plasma. |
| Biotransformation: | Much of the drug is destroyed by enzymatic hydrolysis, particularly in the liver. From 13 to 50% is excreted unchanged in the urine. |
| Route of elimination: | Much of the drug is destroyed by enzymatic hydrolysis, particularly in the liver; from 13 to 50% is excreted unchanged in the urine. |
| Half Life: | 3.0 ± 0.9 hours in adults. The half-life of atropine is slightly shorter (approximately 20 minutes) in females than males. |
| Toxicity: | Oral, mouse: LD50 = 75 mg/kg. Symptoms of overdose includes widespread paralysis of parasympathetically innervated organs. Dry mucous membranes, widely dilated and nonresponsive pupils, tachycardia, fever and cutaneous flush are especially prominent, as are mental and neurological symptoms. In instances of severe intoxication, respiratory depression, coma, circulatory collapse and death may occur. |
| Affected organisms: | Humans and other mammals |
Interactions
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Targets
Enzymes
