Name: | Enflurane |
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PubChem Compound ID: | 11052326 |
Description: | An extremely stable inhalation anesthetic that allows rapid adjustments of anesthesia depth with little change in pulse or respiratory rate. |
Molecular formula: | C3H2ClF5O |
Molecular weight: | 184.492 g/mol |
Synonyms: |
ZINC03872449
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Name: | Enflurane |
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Name (isomeric): | DB00228 |
Drug Type: | small molecule |
Description: | An extremely stable inhalation anesthetic that allows rapid adjustments of anesthesia depth with little change in pulse or respiratory rate. |
Synonyms: |
Anesthetic 347; Enflurano [INN-Spanish]; Anesthetic Compound No. 347; Ohio 347; Enfluranum [INN-Latin]; Methylflurether; Compound 347
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Brand: | Ethrane, Alyrane, Efrane |
Category: | Anesthetics, Inhalation, General Anesthetics |
CAS number: | 13838-16-9 |
Indication: | Used for the induction and maintenance of general anaesthesia during surgery and cesarean section and also used for analgesia during vaginal delivery. |
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Pharmacology: |
Enflurane is an extremely stable halogenated ether inhalation anesthetic that allows rapid adjustments of anesthesia depth with little change in pulse or respiratory rate. Enflurane induces muscle relaxation and reduces pains sensitivity by altering tissue excitability. Induction of and recovery from anesthesia with enflurane are rapid. Enflurane m...
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Mechanism of Action: |
Enflurane induces a reduction in junctional conductance by decreasing gap junction channel opening times and increasing gap junction channel closing times. Enflurane also activates calcium dependent ATPase in the sarcoplasmic reticulum by increasing the fluidity of the lipid membrane. It also appears to bind the D subunit of ATP synthase and NADH d...
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Absorption: | Rapidly absorbed into the circulation via the lungs. |
Protein binding: | 97% |
Biotransformation: | 2.4% of the dose is slowly metabolized hepatically via oxidation and dehalogenation (primarily through the actions of cytochrome P450 2E1). Leads to low levels of serum fluoride (15 µmol/L). |
Toxicity: | LD50=5.4 ml/kg (oral, rat). Symptoms of acute overdose include nausea, vomiting, irritation to the eyes, skin and nose/throat, headache, dizziness, and drowsiness. Symptoms of chronic overdose include hypotension, cardiac arrhythmias, respiratory depression, and liver/kidney dysfunction. |
Affected organisms: | Humans and other mammals |
Drug interaction: |
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