Name: | Fenoprofen |
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PubChem Compound ID: | 10332019 |
Description: | An anti-inflammatory analgesic and antipyretic highly bound to plasma proteins. It is pharmacologically similar to ASPIRIN, but causes less gastrointestinal bleeding. |
Molecular formula: | C15H14O3 |
Molecular weight: | 243.276 g/mol |
Name: | Fenoprofen |
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Name (isomeric): | DB00573 |
Drug Type: | small molecule |
Description: | An anti-inflammatory analgesic and antipyretic highly bound to plasma proteins. It is pharmacologically similar to ASPIRIN, but causes less gastrointestinal bleeding. |
Synonyms: |
Fenoprofen calcium; Fenoprofen calcium hydrate; Feneprofen calcium salt dihydrate
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Brand: | Nalfon |
Category: | Propionic acid derivatives, Cyclooxygenase Inhibitors |
CAS number: | 34597-40-5 |
Indication: | For relief of the signs and symptoms of rheumatoid arthritis and osteoarthritis. Also for the relief of mild to moderate pain. |
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Pharmacology: |
Fenoprofen is a propionic acid derivative with analgesic, antiinflammatory and antipyretic properties. Fenoprofen inhibits prostaglandin synthesis by decreasing the enzyme needed for biosynthesis. In patients with rheumatoid arthritis, the anti-inflammatory action of fenoprofen has been evidenced by relief of pain, increase in grip strength, and re...
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Mechanism of Action: | Fenoprofen's exact mode of action is unknown, but it is thought that prostaglandin synthetase inhibition is involved. Fenoprofen has been shown to inhibit prostaglandin synthetase isolated from bovine seminal vesicles. |
Absorption: | Rapidly absorbed under fasting conditions, and peak plasma levels of 50 µg/mL are achieved within 2 hours after oral administration of 600 mg doses. |
Protein binding: | 99% to albumin. |
Biotransformation: | About 90% of a single oral dose is eliminated within 24 hours as fenoprofen glucuronide and 4'-hydroxyfenoprofen glucuronide, the major urinary metabolites of fenoprofen. |
Half Life: | Plasma half-life is approximately 3 hours. |
Toxicity: | Symptoms of overdose appear within several hours and generally involve the gastrointestinal and central nervous systems. They include dyspepsia, nausea, vomiting, abdominal pain, dizziness, headache, ataxia, tinnitus, tremor, drowsiness, and confusion. Hyperpyrexia, tachycardia, hypotension, and acute renal failure may occur rarely following overdose. Respiratory depression and metabolic acidosis have also been reported following overdose with certain NSAIDs. |
Affected organisms: | Humans and other mammals |
Food interaction: |
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