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QuickView for Flucloxacillin (compound)

Name: Floxacillin
PubChem Compound ID: 21319
Description: Antibiotic analog of CLOXACILLIN.
Molecular formula: C19H17ClFN3O5S
Molecular weight: 453.873 g/mol
Floxapen; Flucloxacillin; 3-(2-Chloro-6-fluorophenyl)-5-methyl-4-isoxazolylpenicillin; C11748; Flucloxacilina [INN-Spanish]; 5250-39-5; EINECS 226-051-0; Flucloxacillinum [INN-Latin]; 4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[[3-(2-chloro-6-fluorophenyl)-5-methyl-4-isoxazolyl]carbonyl]amino]-3,3-dimethyl-7-oxo-, (2S,6R)-; rel-(2R,6S)-6-({[3-(2-chloro-6-fluorophenyl)-5-methylisoxazol-4-yl]carbonyl}amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylato.
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Name: Floxacillin
Name (isomeric): DB00301
Drug Type: small molecule
Description: Antibiotic analog of CLOXACILLIN.
Flucloxacilline [INN-French]; Flucloxacilina [INN-Spanish]; Floxacillin; Flucloxacillin Sodium; Flucloxacillinum [INN-Latin]; Flucloxacillin-Sodium
Brand: Sesamol, Fluclox, Floxapen
Category: Anti-Bacterial Agents, Penicillins
CAS number: 5250-39-5
Indication: Used to treat bacterial infection by susceptible microorganisms.
Flucloxacillin is a penicillin beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually gram-positive, organisms. The name "penicillin" can either refer to several variants of penicillin available, or to the group of antibiotics derived from the penicillins. Flucloxacillin has in vitro activity agai...
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Mechanism of Action: By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, flucloxacillin inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that flucloxacillin interferes with an autolysin inhibitor.
Absorption: Bioavailability is 50–70% following oral administration.
Biotransformation: Hepatic.
Half Life: 0.75–1 hour
Affected organisms: Enteric bacteria and other eubacteria
Food interaction:
Take on an empty stomach.
Drug interaction:
OxytetracyclinePossible antagonism of action
Ethinyl EstradiolThis anti-infectious agent could decrease the effect of the oral contraceptive
MethacyclinePossible antagonism of action
DoxycyclinePossible antagonism of action
DemeclocyclinePossible antagonism of action
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