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QuickView for Oxytetracycline (compound)
PubChem
| Name: | Oxytetracycline |
|---|---|
| PubChem Compound ID: | 11972604 |
| Description: | A TETRACYCLINE analog isolated from the actinomycete STREPTOMYCES rimosus and used in a wide variety of clinical conditions. |
| Molecular formula: | C22H28N2O11 |
| Molecular weight: | 496.465 g/mol |
| Synonyms: |
CAS-6153-64-6; NCGC00017060-01
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DrugBank
Identification
| Name: | Oxytetracycline |
|---|---|
| Name (isomeric): | DB00595 |
| Drug Type: | small molecule |
| Description: | A TETRACYCLINE analog isolated from the actinomycete STREPTOMYCES rimosus and used in a wide variety of clinical conditions. |
| Brand: | Oxytetracycline HCl, Oxytetracycline anhydrous, Terramycin |
| Category: | Anti-Bacterial Agents, Tetracyclines |
| CAS number: | 79-57-2 |
Pharmacology
| Indication: | Oxytetracycline is indicated for treatment of infections caused by a variety of Gram positive and Gram negative microorganisms including <i>Mycoplasma pneumoniae, Pasteurella pestis, Escherichia coli, Haemophilus influenzae</i> (respiratory infections), and <i>Diplococcus pneumoniae</i>. |
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| Pharmacology: |
Oxytetracycline is known as a broad-spectrum antibiotic due to its activity against such a wide range of infections. It was the second of the tetracyclines to be discovered. Oxytetracycline, like other tetracyclines, is used to treat many infections common and rare. Its better absorption profile makes it preferable to tetracycline for moderately se...
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| Mechanism of Action: |
Oxytetracycline inhibits cell growth by inhibiting translation. It binds to the 30S ribosomal subunit and prevents the amino-acyl tRNA from binding to the A site of the ribosome. The binding is reversible in nature. Oxytetracycline is lipophilic and can easily pass through the cell membrane or passively diffuses through porin channels in the bacter...
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| Absorption: | Readily absorbed following oral administration. |
| Toxicity: | Adverse effects may include stomach or bowel upsets and rarely allergic reactions. Very rarely severe headache and vision problems may be signs of dangerous intracranial hypertenion. |
| Affected organisms: | Enteric bacteria and other eubacteria |
Interactions
| Drug interaction: |
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Targets
Transporters
