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QuickView for Halazepam (compound)


PubChem
Name: halazepam
PubChem Compound ID: 31640
Molecular formula: C17H12ClF3N2O
Molecular weight: 352.738 g/mol
Synonyms:
Halazepam (USAN); 2H-1,4-Benzodiazepin-2-one, 1,3-dihydro-7-chloro-5-phenyl-1-(2,2,2-trifluoroethyl)-; DEA No. 2762; 23092-17-3; 2H-1,4-BENZODIAZEPIN-2-ONE, 1,3-DIHYDRO-7-CHLORO-5-PHENYL-1-(2,2,2-TRIFLUOROETHY; Pacinone; Halazepamum [INN-Latin]; Paxipam (TN); 7-Chloro-1,3-dihydro-5-phenyl-1-(2,2,2-trifluoroethyl)-2H-1,4-benzodiazepin-2-one; Schering 12041.
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DrugBank
Identification
Name: halazepam
Name (isomeric): DB00801
Drug Type: small molecule
Synonyms:
Halazepamum [INN-Latin]
Brand: Pacinone, Paxipam
Category: Benzodiazepines, Anti-anxiety Agents, Muscle Relaxants, Sedative
CAS number: 23092-17-3
Pharmacology
Indication: Used to relieve anxiety, nervousness, and tension associated with anxiety disorders.
Mechanism of Action:
Benzodiazepines bind nonspecifically to benzodiazepine receptors BNZ1, which mediates sleep, and BNZ2, which affects affects muscle relaxation, anticonvulsant activity, motor coordination, and memory. As benzodiazepine receptors are thought to be coupled to gamma-aminobutyric acid-A (GABAA) receptors, this enhances the effects of GABA by increasing...
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Biotransformation: Hepatic.
Affected organisms: Humans and other mammals
Interactions
Drug interaction:
ItraconazoleItraconazole may increase the effect of the benzodiazepine, halazepam.
CimetidineCimetidine may increase the effect of the benzodiazepine, halazepam.
KetoconazoleKetoconazole may increase the effect of the benzodiazepine, halazepam.
FluconazoleFluconazole may increase the effect of the benzodiazepine, halazepam.
NelfinavirThe protease inhibitor, nelfinavir, may increase the effect of the benzodiazepine, halazepam.
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Targets