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QuickView for Penicillin V (compound)

Name: Penicillin V
PubChem Compound ID: 4730
Description: A broad-spectrum penicillin antibiotic used orally in the treatment of mild to moderate infections by susceptible gram-positive organisms.
Molecular formula: C16H17N2O5S-
Molecular weight: 349.383 g/mol
Name: Penicillin V
Name (isomeric): DB00417
Drug Type: small molecule
Description: A broad-spectrum penicillin antibiotic used orally in the treatment of mild to moderate infections by susceptible gram-positive organisms.
Penicillin V Potassium; Phenoxymethylenepenicillinic Acid; Penicillin Phenoxymethyl; Phenoxymethylpenicillinic Acid Potassium Salt; Phenoxymethyl Penicillin; Fenoximetilpenicilina [INN-Spanish]; Phenoxymethylpenicillin Potassium; Fenossimetilpenicillina [Dcit]; Phenoximethylpenicillinum; Phenoxymethylpenicillinic Acid
Brand: Crystapen V, Oracillin, Veetids '125', Betapen-Vk, Meropenin, Phenocillin, V-Cyline, Fenospen, Calcipen, Veetids, Distaquaine V, Ospen, Penapar-Vk, V-Tablopen, Eskacillian V, Phenomycilline, Beromycin, V-Cil, Vebecillin, Fenacilin, Ledercillin Vk, Uticillin Vk, Pen-Vee, Pen-Vee K, V-Cillin K, Pen-V, Veetids '250', Oratren, Acipen V, Compocillin V, Apopen, Veetids '500', Stabicillin, V-Cillin, Beepen-Vk, Phenopenicillin, V-Cylina, Robicillin, Pen-Oral, Eskacillin V, Rocilin, Pfizerpen Vk, Fenoxypen, Penicillin-Vk, Penicillin Vk
Brand name mixture:
Mineralytes Sol(Calcium Chloride + Dextrose + Magnesium Chloride + Potassium Acetate + Sodium Acetate + Sodium Chloride), Zoomycetine Spray(Chloramphenicol + Isopropyl Alcohol + Methyl Violet), Pro En Vimi Aureo-Sulfa-Vit(Chlortetracycline Hydrochloride + Sulfamethazine + Vitamin a + Vitamin D3 + Vitamin E), Multi Wormer for Dogs(Dichlorophene +...
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Category: Anti-Bacterial Agents, Penicillins
CAS number: 87-08-1
Indication: For the treatment of mild to moderately severe infections (e.g. dental infection, infections in the heart, middle ear infections, rheumatic fever, scarlet fever, skin infections, upper and lower respiratory tract infections) due to microorganisms
Penicillin V is a penicillin beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually gram-positive, organisms. The name "penicillin" can either refer to several variants of penicillin available, or to the group of antibiotics derived from the penicillins. Penicillin V has in vitro activity against ...
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Mechanism of Action: By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, Penicillin V inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that Penicillin V interferes with an autolysin inhibitor.
Absorption: 25% of the dose given is absorbed, 50-60% bioavailable
Protein binding: 80%
Biotransformation: About 35-70% of an oral dose is metabolized to penicilloic acid, an inactive metabolite. Small amounts of 6-aminopenicillanic acid have been recovered in the urine of patients on penicillin G. A small percentage of the drug appears to be hydroxylated into one or more active metabolites, which are also excreted via urine.
Route of elimination: Mostly renal. A small percentage is eliminated by feces and the biliary route.
Half Life: 30 to 40 minutes
Toxicity: LD50 >1040 mg/kg (Orally in rats with Sodium salt); Nausea, vomiting, stomach pain, diarrhea, and, in rare cases, major motor seizures
Affected organisms: Bacteria
Food interaction:
Absorption is increased when taken on an empty stomach (one hour before or two hours after meals).
Drug interaction:
OxytetracyclinePossible antagonism of action
MethacyclinePossible antagonism of action
DoxycyclinePossible antagonism of action
DemeclocyclinePossible antagonism of action
RolitetracyclinePossible antagonism of action
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