Import Your Data

FAQ

More QuickView FAQs

QuickView

0
Meta-
Analysis

Bookmark Forward

QuickView for Pivampicillin (compound)

Summary
General Info

PubChem

PubChem Compound 126935

PubChem Compound 126935

Name:	Pivampicillin
PubChem Compound ID:	126935
Description:	Pivalate ester analog of AMPICILLIN.
Molecular formula:	C₂₂H₂₉N₃O₆S
Molecular weight:	463.548 g/mol

DrugBank

Identification

Name:	Pivampicillin
Name (isomeric):	DB01604
Drug Type:	small molecule
Description:	Pivalate ester analog of AMPICILLIN.
Synonyms:	Pivampicilline [inn-french]; Pivaloylampicillin; Pivampicillinum [inn-latin]; Pivampicilina [inn-spanish]; Ampicillin pivaloyloxymethyl ester; Pivaloyloxymethyl ampicillinate
Brand:	Pondocillin
Category:	Anti-Bacterial Agents, Penicillins
CAS number:	33817-20-8

Pharmacology

Indication:	or the treatment of respiratory tract infections (including acute bronchitis, acute exacerbations of chronic bronchitis and pneumonia); ear, nose and throat infections; gynecological infections; urinary tract infections (including acute uncomplicated gonococcal urethritis) when caused by non penicillinase-producing susceptible strains of the following organisms: gram-positive organisms, e.g., streptococci, pneumococci and staphylococci; gram-negative organisms, e.g., H. influenzae, N. gonorrhoeae, E. coli, P. mirabilis.
Pharmacology:	Pivampicillin is the pivaloyloxymethyl ester of (the semi-synthetic penicillin) ampicillin. It is an inactive pro-drug, which is converted during its absorption from the gastrointestinal tract to the microbiologically active ampicillin, together with formaldehyde and pivalic acid, by non-specific esterases present in most body tissues. Amounts in e... show more » Pivampicillin is the pivaloyloxymethyl ester of (the semi-synthetic penicillin) ampicillin. It is an inactive pro-drug, which is converted during its absorption from the gastrointestinal tract to the microbiologically active ampicillin, together with formaldehyde and pivalic acid, by non-specific esterases present in most body tissues. Amounts in excess of 99% of the pivampicillin absorbed are converted to ampicillin within 15 minutes of absorption. show less «
Mechanism of Action:	Ampicillin (the active metabolite of pivampicillin) has a bactericidal action resulting from inhibition of cell wall mucopeptide biosynthesis.
Absorption:	Absorbed following oral administration.
Half Life:	Approximately 1 hour.
Affected organisms:	Enteric bacteria and other eubacteria

Interactions

Food interaction:

Take without regard to meals.

Drug interaction:

Oxytetracycline	Possible antagonism of action
Ethinyl Estradiol	This anti-infectious agent could decrease the effect of the oral contraceptive
Methacycline	Possible antagonism of action
Doxycycline	Possible antagonism of action
Demeclocycline	Possible antagonism of action

Targets

Penicillin-binding proteins 1A/1B