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QuickView for clavulanate (compound)
DrugBank
Identification
| Name: | Clavulanate |
|---|---|
| Name (isomeric): | DB00766 |
| Drug Type: | small molecule |
| Synonyms: |
Clavulanic Acid
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| Brand name mixture: | Amoksiklav(potassium clavulanate + amoxicillin), Neo-Duplamox(potassium clavulanate + amoxicillin), Klavocin(potassium clavulanate + amoxicillin), Augmentin(potassium clavulanate + amoxicillin), Ciblor(potassium clavulanate + amoxicillin) |
| Category: | Anti-Bacterial Agents, Enzyme Inhibitors |
| CAS number: | 58001-44-8 |
Pharmacology
| Indication: | For use with Amoxicillin, clavulanic acid is suitable for the treatment of infections with <i>Staph. aureus</i> and <i>Bacteroides fragilis</i>, or with beta-lactamase producing <i>H. influenzae</i> and <i>E. coli</i>. |
|---|---|
| Pharmacology: | Clavulanic acid, produced by the fermentation of Streptomyces Clavuligerus, is a beta-lactam structurally related to the penicillins. Clavulanic acid is used in conjunction with amoxicillin for the treatment of bronchitis and urinary tract, skin, and soft tissue infections caused by beta-lactamase producing organisms. |
| Mechanism of Action: |
Clavulanic acid competitively and irreversibly inhibits a wide variety of beta-lactamases, commonly found in microorganisms resistant to penicillins and cephalosporins. Binding and irreversibly inhibiting the beta-lactamase results in a restauration of the antimicrobial activity of beta-lactam antibiotics against lactamase-secreting-resistant bacte...
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| Absorption: | 75% |
| Protein binding: | Low (22 to 30%) |
| Biotransformation: | Hepatic |
| Half Life: | 1.0 hour |
| Toxicity: | Gastrointestinal symptoms including stomach and abdominal pain, vomiting, and diarrhea. Rash, hyperactivity, or drowsiness have also been observed in a small number of patients |
| Affected organisms: | Enteric bacteria and other eubacteria |
Interactions
| Drug interaction: |
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Targets
