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QuickView for n%20methylscopolamine (compound)

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PubChem

PubChem Compound 4120

PubChem Compound 4120

Name:	N-Methylscopolamine
PubChem Compound ID:	4120
Description:	A muscarinic antagonist used to study binding characteristics of muscarinic cholinergic receptors.
Molecular formula:	C₁₈H₂₄NO₄⁺
Molecular weight:	318.388 g/mol
Synonyms:	Epoxymethamine bromide; Methoscopylamine bromide; nsc61809; (-)-Tropate(ester); Nutrop; Neo-Avagal; Methylscopolamine bromide; Epoxytropine tropate methylbromide; (-)-Scopolamine methyl bromide; 1.alpha.-H,5.alpha.H-Tropanium, 6.beta., 7.beta.-epoxy-3.alpha.-hydroxy-8-methyl-, bromide, (-)-tropate. show more » Epoxymethamine bromide; Methoscopylamine bromide; nsc61809; (-)-Tropate(ester); Nutrop; Neo-Avagal; Methylscopolamine bromide; Epoxytropine tropate methylbromide; (-)-Scopolamine methyl bromide; 1.alpha.-H,5.alpha.H-Tropanium, 6.beta., 7.beta.-epoxy-3.alpha.-hydroxy-8-methyl-, bromide, (-)-tropate; 1.alpha.H,5.alpha.H-Tropanium, 6.beta., 7.beta.-epoxy-3.alpha.-hydroxy-8-methyl-, bromide, (-)-tropate; N-Methylhyoscine bromide; Scopolamine methobromide; Hyoscine methylbromide; NSC120606; Scopolammonium, N-methylbromide; Restropin; Scopolamin methylbromide; 155-41-9; 9,9-dimethyl-3-oxa-95-azatricyclo[3.3.1.0~2,4~]non-7-yl tropate; Paraspan; Lescopine bromide; Pamine; Scopolammonium, N-methyl-, bromide; Pamine Bromide; Blocan; Methylscopolamine hydrobromide; 3-Oxa-9-azoniatricyclo[3.3.1.02,4]nonane, 7- (3-hydroxy-1-oxo-2-phenylpropoxy)-9,9-dimethyl-, bromide, [7(S)-(1.alpha.,2.beta.,4.beta.,5.alpha.,7.beta.)]-; Methscopolamine methylbromide; Diopal; Scopolamine methylbromide; Holopon; Proscomide; Methscopolamine bromide; N-Methylscopolammonium Bromide; Mescopil; Ampyrox show less «

DrugBank

Identification

Name:	N-Methylscopolamine
Name (isomeric):	DB00462
Drug Type:	small molecule
Description:	A muscarinic antagonist used to study binding characteristics of muscarinic cholinergic receptors.
Synonyms:	Methylscopolamine Bromide; Scopolamine Methobromide; Scopolamin Methylbromide; Epoxymethamine Bromide; Methoscopylamine Bromide; N-Methylscopolamine Methylsulfate; Epoxytropine Tropate Methylbromide; Methscopolamine Methylbromide; Hyoscine Methobromide; Methylscopolamine Hydrobromide. show more » Methylscopolamine Bromide; Scopolamine Methobromide; Scopolamin Methylbromide; Epoxymethamine Bromide; Methoscopylamine Bromide; N-Methylscopolamine Methylsulfate; Epoxytropine Tropate Methylbromide; Methscopolamine Methylbromide; Hyoscine Methobromide; Methylscopolamine Hydrobromide; Scopolamine Methylbromide; N-Methylscopolammonium Bromide; Hyoscine Methylbromide; Lescopine Bromide; N-Methylhyoscine Bromide; Methscopolamine show less «
Brand:	Holopon, Proscomide, Restropin, Mescopil, Pamine, Transderm Scop, Diopal, Blocan, Daipin, Ampyrox, Nutrop, Neo-Avagal, Paraspan
Brand name mixture:	Neosol M Aquadrops(methscopolamine bromide + neomycin), Scour solution coop(methscopolamine bromide + neomycin), Neomix-pamine Scour Bolus(methscopolamine bromide + neomycin sulfate), Scour solution(methscopolamine bromide + neomycin), Neomix-pamine Solution(methscopolamine bromide + neomycin sulfate), Biosol-M-Aquadrops liq(methscopolamine brom... show more » Neosol M Aquadrops(methscopolamine bromide + neomycin), Scour solution coop(methscopolamine bromide + neomycin), Neomix-pamine Scour Bolus(methscopolamine bromide + neomycin sulfate), Scour solution(methscopolamine bromide + neomycin), Neomix-pamine Solution(methscopolamine bromide + neomycin sulfate), Biosol-M-Aquadrops liq(methscopolamine bromide + neomycin sulfate) show less «
Category:	Parasympatholytics, Anticholinergic Agents, Antispasmodics
CAS number:	155-41-9

Pharmacology

Indication:	Used as adjunctive therapy for the treatment of peptic ulcer. Also used to treat nausea and vomiting due to motion sickness.
Pharmacology:	Methscopolamine is a muscarinic antagonist structurally similar to the neurotransmitter acetylcholine and acts by blocking the muscarinic acetylcholine receptors and is thus classified as an anticholinergic. Methscopolamine has many uses including the prevention of motion sickness. It is not clear how Methscopolamine prevents nausea and vomiting du... show more » Methscopolamine is a muscarinic antagonist structurally similar to the neurotransmitter acetylcholine and acts by blocking the muscarinic acetylcholine receptors and is thus classified as an anticholinergic. Methscopolamine has many uses including the prevention of motion sickness. It is not clear how Methscopolamine prevents nausea and vomiting due to motion sickness. The vestibular part of the ear is very important for balance. When a person becomes disoriented due to motion, the vestibule sends a signal through nerves to the vomiting center in the brain, and vomiting occurs. Acetylcholine is a chemical that nerves use to transmit messages to each other. It is believe that Methscopolamine prevents communication between the nerves of the vestibule and the vomiting center in the brain by blocking the action of acetylcholine. Methscopolamine also may work directly on the vomiting center. Methscopolamine must be taken before the onset of motion sickness to be effective. show less «
Mechanism of Action:	Methscopolamine acts by interfering with the transmission of nerve impulses by acetylcholine in the parasympathetic nervous system (specifically the vomiting center). It does so by acting as a muscarinic antagonist.
Absorption:	Poorly and unreliably absorbed, total absorption is 10-25%.
Biotransformation:	Little is known about the fate and excretion of methscopolamine.
Toxicity:	Symptoms of a methscopolamine overdose include headache, nausea, vomiting, dry mouth, difficulty swallowing, blurred vision, dilated pupils, hot, dry skin, dizziness; drowsiness, confusion, anxiety, seizures, weak pulse, and an irregular heartbeat. In addition, a curare-like action may occur, i.e., neuromuscular blockade leading to muscular weakness and possible paralysis.
Affected organisms:	Humans and other mammals

Interactions

Drug interaction:

Tacrine	The therapeutic effects of the central acetylcholinesterase inhibitor, Tacrine, and/or the anticholinergic, Methylscopolamine, may be reduced due to antagonism. The interaction may be beneficial when the anticholinergic action is a side effect. Monitor for decreased efficacy of both agents.
Donepezil	Possible antagonism of action
Trospium	Trospium and Methylscopolamine, two anticholinergics, may cause additive anticholinergic effects and enhanced adverse/toxic effects. Monitor for enhanced anticholinergic effects.
Trimethobenzamide	Trimethobenzamide and Methylscopolamine, two anticholinergics, may cause additive anticholinergic effects and enhance their adverse/toxic effects. Monitor for enhanced anticholinergic effects.
Triprolidine	Triprolidine and Methylscopolamine, two anticholinergics, may cause additive anticholinergic effects and enhance their adverse/toxic effects. Monitor for enhanced anticholinergic effects.

Targets

Muscarinic acetylcholine receptor M1

Muscarinic acetylcholine receptor M2

Muscarinic acetylcholine receptor M3