Bookmark
Forward
QuickView for state government (compound)
PubChem
| Name: | Flunitrazepam |
|---|---|
| PubChem Compound ID: | 3380 |
| Description: | A benzodiazepine with pharmacologic actions similar to those of DIAZEPAM that can cause ANTEROGRADE AMNESIA. Some reports indicate that it is used as a date rape drug and suggest that it may precipitate violent behavior. The United States Government has banned the importation of this drug. |
| Molecular formula: | C16H12FN3O3 |
| Molecular weight: | 313.283 g/mol |
| Synonyms: |
Rohypnol; 1,3-Dihydro-5-(o-fluorophenyl)-1-methyl-7-nitro-2H-1,4-benzodiazepin-2-one; EINECS 216-597-8; 5-(o-Fluorophenyl)-1,3-dihydro-1-methyl-7-nitro-2H-1,4-benzodiazepin-2-one; DEA No. 2763; CCRIS 5287; NSC708829; DivK1c_000981; HSDB 6960; Flunitrazepamum [INN-Latin].
show more » |
DrugBank
Identification
| Name: | Flunitrazepam |
|---|---|
| Name (isomeric): | DB01544 |
| Drug Type: | small molecule |
| Description: | A benzodiazepine with pharmacologic actions similar to those of DIAZEPAM that can cause ANTEROGRADE AMNESIA. Some reports indicate that it is used as a date rape drug and suggest that it may precipitate violent behavior. The United States Government has banned the importation of this drug. |
| Synonyms: |
Flunitrazepamum [inn-latin]
|
| Brand: | Narcozep, Roipnol, Rohypnol, Primun |
| Category: | Benzodiazepines, Anti-anxiety Agents, GABA Modulators, Hypnotics and Sedatives |
| CAS number: | 1622-62-4 |
Pharmacology
| Indication: | For short-term treatment of severe insomnias, that are not responsive to other hypnotics. |
|---|---|
| Pharmacology: |
Flunitrazepam is a powerful hypnotic drug that is a benzodiazepine derivative. It has powerful hypnotic, sedative, anxiolytic, and skeletal muscle relaxant properties. The drug is sometimes used as a date rape drug. In the United States, the drug has not been approved by the Food and Drug Administration for medical use, and is considered to be an i...
show more » |
| Mechanism of Action: |
Benzodiazepines bind nonspecifically to benzodiazepine receptors BNZ1, which mediates sleep, and BNZ2, which affects affects muscle relaxation, anticonvulsant activity, motor coordination, and memory. As benzodiazepine receptors are thought to be coupled to gamma-aminobutyric acid-A (GABAA) receptors, this enhances the effects of GABA by increasing...
show more » |
| Absorption: | 50% (suppository) and 64-77% (oral) |
| Biotransformation: | Hepatic. |
| Half Life: | 18-26 hours |
| Toxicity: | Symptoms of overdose include confusion, coma, impaired coordination, sleepiness, and slowed reaction time. |
| Affected organisms: | Humans and other mammals |
Interactions
| Food interaction: |
| ||||
|---|---|---|---|---|---|
| Drug interaction: |
|
Targets
Enzymes
