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PubChem
| Name: | Salicylic Acid |
|---|---|
| PubChem Compound ID: | 134971 |
| Description: | A compound obtained from the bark of the white willow and wintergreen leaves, and also prepared synthetically. It has bacteriostatic, fungicidal, and keratolytic actions. Its salts, the salicylates, are used as analgesics. (From Dorland's, 28th ed) |
| Molecular formula: | C7H6O3 |
| Molecular weight: | 140.113 g/mol |
| Synonyms: |
14C-Salicylic acid; Salicylic-1-14C acid; 33148-23-1
|
DrugBank
Identification
| Name: | Salicylic Acid |
|---|---|
| Name (isomeric): | DB00936 |
| Drug Type: | small molecule |
| Description: | A compound obtained from the bark of the white willow and wintergreen leaves, and also prepared synthetically. It has bacteriostatic, fungicidal, and keratolytic actions. Its salts, the salicylates, are used as analgesics. (From Dorland's, 28th ed) |
| Synonyms: |
Salicylic acid; Salicylate; Acido salicilico; Phenol-2-carboxylic acid; O-carboxyphenol; O-hydroxybenzoic acid; Orthohydroxybenzoic acid; 2-Hydroxybenzoic acid; 2-Carboxyphenol; 2-Hydroxybenzenecarboxylic acid.
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| Brand: | Dr. Scholl's Callus Removers, Freezone, Saligel, Kyselina salicylova, Dr. Scholl's Corn Removers, Advanced pain relief callus removers, Salicylic acid soap, Duofil Wart Remover, Retarder SAX, Kyselina 2-hydroxybenzoova, Stri-dex, Duoplant, Ionil, Rutranex, Salonil, Compound W, Clear away wart remover, Salicylic acid collodion, Keralyt, Retarder W, Psoriacid-s-stift, Advanced pain relief corn removers, SAX, Dr. Scholl's Wart Remover Kit |
| Brand name mixture: | Mobilat() |
| Category: | Keratolytic Agents, Anti-Infective Agents, Antifungal Agents |
| CAS number: | 69-72-7 |
Pharmacology
| Indication: | Key additive in many skin-care products for the treatment of acne, psoriasis, callouses, corns, keratosis pilaris and warts. |
|---|---|
| Pharmacology: |
Salicylic acid treats acne by causing skin cells to slough off more readily, preventing pores from clogging up. This effect on skin cells also makes salicylic acid an active ingredient in several shampoos meant to treat dandruff. Use of straight salicylic solution may cause hyperpigmentation on unpretreated skin for those with darker skin types (Fi...
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| Mechanism of Action: |
Salicylic acid directly and irreversibly inhibits the activity of both types of cyclo-oxygenases (COX-1 and COX-2) to decrease the formation of precursors of prostaglandins and thromboxanes from arachidonic acid. Salicylate may competitively inhibit prostaglandin formation. Salicylate's antirheumatic (nonsteroidal anti-inflammatory) actions are a ...
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| Toxicity: | Oral rat LD50: 891 mg/kg. Inhalation rat LC50: > 900 mg/m3/1hr. Irritation: skin rabbit: 500 mg/24H mild. Eye rabbit: 100 mg severe. Investigated a mutagen and reproductive effector. |
| Affected organisms: | Humans and other mammals |
Targets
Enzymes
Transporters
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