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QuickView for Chlorotrianisene (compound)

Name: Chlorotrianisene
PubChem Compound ID: 11289
Description: A powerful synthetic, non-steroidal estrogen.
Molecular formula: C23H21ClO3
Molecular weight: 380.864 g/mol
Chlorotrisin; Rianil; Chlorotrianisene [BAN:INN]; Clorotrianiseno [INN-Spanish]; Chlortrianisoestrolum; Clorotrianisene [DCIT]; Benzene, 1,1',1''-(1-chloro-1-ethenyl-2-ylidene)tris(4-methoxy)-; SMR000058658; Chlortrianisen; Spectrum4_000954.
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Name: Chlorotrianisene
Name (isomeric): DB00269
Drug Type: small molecule
Description: A powerful synthetic, non-steroidal estrogen.
Chlorotrianisine; Chlorestrolo; Clorotrianiseno [INN-Spanish]; Chlorotrianizen; Chlortrianisoestrolum; Chlorotrianisenum [INN-Latin]; CTA; Chlortrianisestrol; Chlortrianisene; Chlortrianisen.
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Brand: Tace, Clorestrolo, Trianisestrol, Clorotrisin, Rianil, Hormonisene, Merbentul, Anisene, Tace-Fn, Metace, Khlortrianizen, Chlorotrisin
Category: Antineoplastic Agents, Hormonal, Estrogens, Non-Steroidal, Antineoplastic Agents
CAS number: 569-57-3
Indication: Used to treat symptoms of menopause, deficiencies in ovary function (including underdevelopment of female sexual characteristics and some types of infertility), and in rare cases, prostate cancer. Chlorotrianisene may also be used to prevent breast engorgement following childbirth.
Chlorotrianisene is a nonsteroidal synthetic estrogen. After menopause, when the body no longer produces estrogen, chlorotrianisene is used as a simple replacement of estrogen. The estrogen-stimulated endometrium may bleed within 48-72 hours after discontinuance of estrogen therapy. Paradoxically, prolonged estrogen therapy may cause shrinkage of t...
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Mechanism of Action:
Chlorotrianisene binds to the estrogen receptor on various estrogen receptor bearing cells. Target cells include cells in the female reproductive tract, the mammary gland, the hypothalamus, and the pituitary. Estrogens increase the hepatic synthesis of sex hormone binding globulin (SHBG), thyroid-binding globulin (TBG), and other serum proteins and...
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Absorption: Absorption following oral administration is rapid.
Protein binding: 50-80%
Biotransformation: Metabolized principally in the liver, although the kidneys, gonads, and muscle tissues may be involved to some extent. The metabolic fate of the synthetic estrogens has not been fully elucidated.
Toxicity: Acute overdosage of large doses of oral contraceptives in chidren reportedly produces almost no toxicity except nausea and vomiting. Acute overdosage of estrogens may cause nausea, and withdrawal bleeding may occur in females.
Affected organisms: Humans and other mammals
Drug interaction:
RaloxifeneAssociation not recommended
PhenytoinThe enzyme inducer, phenytoin, decreases the effect of the hormone agent, chlorotrianisene.
PrednisoneThe estrogenic agent, chlorotrianisene, may increase the effect of corticosteroid, prednisone.
PhenobarbitalThe enzyme inducer, phenobarbital, decreases the effect of the hormone agent, chlorotrianisene.
PrednisoloneThe estrogenic agent, chlorotrianisene, may increase the effect of the corticosteroid, prednisolone.
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