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QuickView for Griseofulvin (compound)

Name: Griseofulvin
PubChem Compound ID: 3512
Description: An antifungal antibiotic. Griseofulvin may be given by mouth in the treatment of tinea infections.
Molecular formula: C17H17ClO6
Molecular weight: 352.766 g/mol
LABOTEST-BB LT00244818; BAS 00463344; MLS000028436; 78739-00-1; Griseostatin; Grisowen; Gris-PEG; NSC34533; Griseofulvin; NSC41728.
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Name: Griseofulvin
Name (isomeric): DB00400
Drug Type: small molecule
Description: An antifungal antibiotic. Griseofulvin may be given by mouth in the treatment of tinea infections.
Griseofulvinum [INN-Latin]; Griseofulvine [INN-French]; Griseofulvina [INN-Spanish]
Brand: Fulvina, Fulvicin, Grifulvin, Grisactin Ultra, Lamoryl, Fungivin, Neocid, Griseofulvin forte, Grisofulvin, Sporostatin, Grisefuline, Gricin, Griseo, Grisetin, Grizeofulvin, Sporostatin xan, Grisactin, Gresfeed, Fulvican grisactin, Gris-PEG, Fulvicin-U/F, Griscofulvin, Likuden, Poncyl, Spirofulvin, Neo-Fulcin, Fulvicin-P/G, Griseomix, Delmofulvina, Grisovin, Amudane, Fulvistatin, Greosin, Grifulvin V, Grysio, Fulvicin P/G, Guservin, Fulcin, Fulvinil, Fulvicin U/F, Murfulvin, Biogrisin-fp, Grisovin FP, Fulcine, Grifulin, Griseofulvin-forte, Curling factor, Likunden, Xuanjing
Category: Antibacterial Agents, Antibiotics, Antifungal
CAS number: 126-07-8
Indication: For the treatment of ringworm infections of the skin, hair, and nails, namely: tinea corporis, tinea pedis, tinea cruris, tinea barbae, cradle cap or other conditions caused by <i>Trichophyton</i> or <i>Microsporum</i> fungi.
Griseofulvin is a mycotoxic metabolic product of Penicillium spp. It was the first available oral agent for the treatment of dermatophytoses and has now been used for more than forty years. Griseofulvin is fungistatic with in vitro activity against various species of Microsporum Epidermophyton, and Trichophyton. It has no effect on bacteria ...
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Mechanism of Action:
Griseofulvin is fungistatic, however the exact mechanism by which it inhibits the growth of dermatophytes is not clear. It is thought to inhibit fungal cell mitosis and nuclear acid synthesis. It also binds to and interferes with the function of spindle and cytoplasmic microtubules by binding to alpha and beta tubulin. It binds to keratin in human ...
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Absorption: Poorly absorbed from GI ranging from 25 to 70% of an oral dose. Absorption is significantly enhanced by administration with or after a fatty meal.
Biotransformation: Primarily hepatic with major metabolites being 6-methyl-griseofulvin and its glucuronide conjugate.
Half Life: 9-21 hours
Toxicity: Side effects are minor: headaches, gastrointestinal reactions and cutaneous eruptions
Affected organisms: Yeast and other Trichophyton or Microsporum fungi
Food interaction:
Avoid alcohol.
Take this medication with a high fat meal, fatty foods increase bioavailability.
Drug interaction:
SecobarbitalThe barbiturate, secobarbital, decreases the effect of griseofulvin.
HexobarbitalThe barbiturate, hexobarbital, decreases the effect of griseofulvin.
AnisindioneGriseofulvin may decrease the anticoagulant effect of anisindione.
DiethylstilbestrolThe enzyme inducer, griseofulvin, decreases the effect of the hormone agent, diethylstilbestrol.
Ethinyl EstradiolThis product may cause a slight decrease of contraceptive effect
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