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QuickView for Prednisone (compound)

Name: Prednisone
PubChem Compound ID: 11908428
Description: A synthetic anti-inflammatory glucocorticoid derived from CORTISONE. It is biologically inert and converted to PREDNISOLONE in the liver.
Molecular formula: C21H26O5
Molecular weight: 358.428 g/mol
Name: Prednisone
Name (isomeric): DB00635
Drug Type: small molecule
Description: A synthetic anti-inflammatory glucocorticoid derived from CORTISONE. It is biologically inert and converted to PREDNISOLONE in the liver.
PRD; Dehydrocortisone; Prednisonum [INN-Latin]; Prednisona [INN-Spanish]
Brand: Encorton, Econosone, Diadreson, Ancortone, Decortin, Cortidelt, Prednidib, Cortancyl, Fernisone, Presone, Prednicen-M, Pehacort, Dekortin, Prednison, Lisacort, Paracort, Delta Cortelan, Ultracortene, Adasone, Zenadrid, Dellacort, Supercortil, Origen Prednisone, Sone, Panafcort, Deltison, Deltisone, Pronison, Dacorten, Deltacortene, Di-Adreson, Metacortandracin, Prednizon, Colisone, Prednitone, Delta E, Sterapred, Precort, Prednicot, Delta-cortone, Deltra, Dellacort A, Deltisona, Prednilonga, Novoprednisone, Wojtab, Dacortin, Juvason, Servisone, Encortone, Deltacortisone, Deltacortone, Delta-dome, Winpred, Prednisone Intensol, Prednicorm, Parmenison, Orasone, Delta-cortisone, In-Sone, Predeltin, Nurison, Prednicort, Nizon, Ultracorten, Me-Korti, Retrocortine, Hostacortin, Deltasone, Betapar, Incocortyl, Nisona, Bicortone, Fiasone, Cotone, Cartancyl, Prednovister, Delcortin, Decortancyl, Delta-cortelan, Apo-prednisone, Rectodelt, Cortan, Decortisyl, Enkorton, Panasol, Meticorten
Brand name mixture:
Metreton Tab(Chlorpheniramine Maleate + Prednisone + Vitamin C), Sterolin Liq(Biotin + Fatty Acids Unsaturated + Inositol + Nicotinic Acid + Pheniramine Maleate + Phosphatidyl Choline + Prednisone + Vitamin a Palmitate + Vitamin B2 + Vitamin D2 + Vitamin E), Predniderm Tab(Inositol + Pheniramine Maleate + Phosphatidyl Choline + Prednisone + Vita...
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Category: Antineoplastic Agents, Hormonal, Adrenergic Agents, Antineoplastic Agents, Glucocorticoids, Anti-inflammatory Agents
CAS number: 53-03-2
Indication: For the treatment of drug-induced allergic reactions, perennial or seasonal allergic rhinitis, serum sickness, giant cell arteritis acute rheumatic or nonrheumatic carditis, systemic dermatomyositis, systemic lupus erythematosus, atopic dermatitis, contact dermatitis, exfoliative dermatitis, bullous dermatitis herpetiformis, severe seborrheic dermatitis, severe (Stevens-Johnson syndrome) erythema multiforme, mycosis fungoides, pemphigus, severe psoriasis, acute adrenocortical insufficiency, Addison's disease, secondary adrenocortical insufficiency, congenital adrenal hyperplasia, hypercalcemia associated with neoplasms, nonsuppurative thyroiditis, ulceratice colitis, Crohn's disease, acquired hemolytic anemia, congenital hypoplastic anemia, erythroblastopenia, adult secondary thrombocytopenia, adult idiopathic thrombocytopenia purpura, acute or subacute bursitis, epicondylitis, acute nonspecific tenosynovitis, acute or chronic lymphocytic leukemia, Hodgkin's or non-Hodgkin's lynphomas, Waldenstrom's macroglobulinemia, primary brain tumors (adjunct), nephrotic syndrome, tuberculous meningitis, multiple sclerosis, myasthenia gravis. cerebral edema, chorioretinitis, diffuse posterior choroiditis, aleergic conjunctivitis, Herpes zoster ophthalmicus, anterior segment inflammation, iridocyclitis, iritis, keratitis, optoc neuritis, sympathetic ophthalmia, corneal marginal allergic ulcers, symptomatic sarcoidosis, Loeffler's syndrome not manageable by other means, berylliosis, fulminating or disseminated pulmonary tuberculosis when used concurrently with appropriate antituberculous chemotherapy and aspiration pneumonitis.
Pharmacology: Prednisone, the most commonly-prescribed corticosteroid, is used to treat allograft rejection, asthma, systemic lupus erythematosus, and many other inflammatory states. Prednisone has very little mineralocorticoid activity.
Mechanism of Action:
Prednisone is a glucocorticoid receptor agonist. It is first metabolized in the liver to its active form, prednisolone. Prednisolone crosses cell membranes and binds with high affinity to specific cytoplasmic receptors. The result includes inhibition of leukocyte infiltration at the site of inflammation, interference in the function of mediators of...
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Absorption: Readily absorbed from the gastrointestinal tract.
Protein binding: Extensively bound to plasma proteins.
Biotransformation: Hepatic.
Half Life: 2 to 3 hours
Affected organisms: Humans and other mammals
Food interaction:
Avoid alcohol.
Take with food to reduce irritation.
Avoid taking with grapefruit juice.
Drug interaction:
EstropipateThe estrogenic agent, estropipate, may increase the effect of corticosteroid, prednisone.
EdrophoniumThe corticosteroid, prednisone, may decrease the effect of the anticholinesterase, edrophonium.
SecobarbitalThe barbiturate, secobarbital, may decrease the effect of the corticosteroid, prednisone.
ChlorotrianiseneThe estrogenic agent, chlorotrianisene, may increase the effect of corticosteroid, prednisone.
EthotoinThe enzyme inducer, ethotoin, may decrease the effect of the corticosteroid, prednisone.
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