QuickView for Prednisone (compound)

Summary
General Info

PubChem

PubChem Compound 11908428

Name:	Prednisone
PubChem Compound ID:	11908428
Description:	A synthetic anti-inflammatory glucocorticoid derived from CORTISONE. It is biologically inert and converted to PREDNISOLONE in the liver.
Molecular formula:	C₂₁H₂₆O₅
Molecular weight:	358.428 g/mol
Synonyms:	ZINC05223485

DrugBank

Identification

Name:	Prednisone
Name (isomeric):	DB00635
Drug Type:	small molecule
Description:	A synthetic anti-inflammatory glucocorticoid derived from CORTISONE. It is biologically inert and converted to PREDNISOLONE in the liver.
Synonyms:	PRD; Dehydrocortisone; Prednisonum [INN-Latin]; Prednisona [INN-Spanish]
Brand:	Encorton, Econosone, Diadreson, Ancortone, Decortin, Cortidelt, Prednidib, Cortancyl, Fernisone, Presone, Prednicen-M, Pehacort, Dekortin, Prednison, Lisacort, Paracort, Delta Cortelan, Ultracortene, Adasone, Zenadrid, Dellacort, Supercortil, Origen Prednisone, Sone, Panafcort, Deltison, Deltisone, Pronison, Dacorten, Deltacortene, Di-Adreson, Metacortandracin, Prednizon, Colisone, Prednitone, Delta E, Sterapred, Precort, Prednicot, Delta-cortone, Deltra, Dellacort A, Deltisona, Prednilonga, Novoprednisone, Wojtab, Dacortin, Juvason, Servisone, Encortone, Deltacortisone, Deltacortone, Delta-dome, Winpred, Prednisone Intensol, Prednicorm, Parmenison, Orasone, Delta-cortisone, In-Sone, Predeltin, Nurison, Prednicort, Nizon, Ultracorten, Me-Korti, Retrocortine, Hostacortin, Deltasone, Betapar, Incocortyl, Nisona, Bicortone, Fiasone, Cotone, Cartancyl, Prednovister, Delcortin, Decortancyl, Delta-cortelan, Apo-prednisone, Rectodelt, Cortan, Decortisyl, Enkorton, Panasol, Meticorten
Brand name mixture:	Metreton Tab(Chlorpheniramine Maleate + Prednisone + Vitamin C), Sterolin Liq(Biotin + Fatty Acids Unsaturated + Inositol + Nicotinic Acid + Pheniramine Maleate + Phosphatidyl Choline + Prednisone + Vitamin a Palmitate + Vitamin B2 + Vitamin D2 + Vitamin E), Predniderm Tab(Inositol + Pheniramine Maleate + Phosphatidyl Choline + Prednisone + Vita... show more » Metreton Tab(Chlorpheniramine Maleate + Prednisone + Vitamin C), Sterolin Liq(Biotin + Fatty Acids Unsaturated + Inositol + Nicotinic Acid + Pheniramine Maleate + Phosphatidyl Choline + Prednisone + Vitamin a Palmitate + Vitamin B2 + Vitamin D2 + Vitamin E), Predniderm Tab(Inositol + Pheniramine Maleate + Phosphatidyl Choline + Prednisone + Vitamin a + Vitamin D2 + Vitamin E), Cortab(Biotin + Chlorpheniramine Maleate + D-Pantothenic Acid + Inositol + Nicotinic Acid + Prednisone + Pyridoxine Hydrochloride + Thiamine Mononitrate + Vitamin a + Vitamin B2 + Vitamin D + Vitamin E (Dl-Alpha Tocopheryl Acetate)) show less «
Category:	Antineoplastic Agents, Hormonal, Adrenergic Agents, Antineoplastic Agents, Glucocorticoids, Anti-inflammatory Agents
CAS number:	53-03-2

Pharmacology

Indication:	For the treatment of drug-induced allergic reactions, perennial or seasonal allergic rhinitis, serum sickness, giant cell arteritis acute rheumatic or nonrheumatic carditis, systemic dermatomyositis, systemic lupus erythematosus, atopic dermatitis, contact dermatitis, exfoliative dermatitis, bullous dermatitis herpetiformis, severe seborrheic dermatitis, severe (Stevens-Johnson syndrome) erythema multiforme, mycosis fungoides, pemphigus, severe psoriasis, acute adrenocortical insufficiency, Addison's disease, secondary adrenocortical insufficiency, congenital adrenal hyperplasia, hypercalcemia associated with neoplasms, nonsuppurative thyroiditis, ulceratice colitis, Crohn's disease, acquired hemolytic anemia, congenital hypoplastic anemia, erythroblastopenia, adult secondary thrombocytopenia, adult idiopathic thrombocytopenia purpura, acute or subacute bursitis, epicondylitis, acute nonspecific tenosynovitis, acute or chronic lymphocytic leukemia, Hodgkin's or non-Hodgkin's lynphomas, Waldenstrom's macroglobulinemia, primary brain tumors (adjunct), nephrotic syndrome, tuberculous meningitis, multiple sclerosis, myasthenia gravis. cerebral edema, chorioretinitis, diffuse posterior choroiditis, aleergic conjunctivitis, Herpes zoster ophthalmicus, anterior segment inflammation, iridocyclitis, iritis, keratitis, optoc neuritis, sympathetic ophthalmia, corneal marginal allergic ulcers, symptomatic sarcoidosis, Loeffler's syndrome not manageable by other means, berylliosis, fulminating or disseminated pulmonary tuberculosis when used concurrently with appropriate antituberculous chemotherapy and aspiration pneumonitis.
Pharmacology:	Prednisone, the most commonly-prescribed corticosteroid, is used to treat allograft rejection, asthma, systemic lupus erythematosus, and many other inflammatory states. Prednisone has very little mineralocorticoid activity.
Mechanism of Action:	Prednisone is a glucocorticoid receptor agonist. It is first metabolized in the liver to its active form, prednisolone. Prednisolone crosses cell membranes and binds with high affinity to specific cytoplasmic receptors. The result includes inhibition of leukocyte infiltration at the site of inflammation, interference in the function of mediators of... show more » Prednisone is a glucocorticoid receptor agonist. It is first metabolized in the liver to its active form, prednisolone. Prednisolone crosses cell membranes and binds with high affinity to specific cytoplasmic receptors. The result includes inhibition of leukocyte infiltration at the site of inflammation, interference in the function of mediators of inflammatory response, suppression of humoral immune responses, and reduction in edema or scar tissue. The antiinflammatory actions of corticosteroids are thought to involve phospholipase A2 inhibitory proteins, lipocortins, which control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes. show less «
Absorption:	Readily absorbed from the gastrointestinal tract.
Protein binding:	Extensively bound to plasma proteins.
Biotransformation:	Hepatic.
Half Life:	2 to 3 hours
Affected organisms:	Humans and other mammals

Interactions

Food interaction:

Avoid alcohol.

Take with food to reduce irritation.

Avoid taking with grapefruit juice.

Drug interaction:

Estropipate	The estrogenic agent, estropipate, may increase the effect of corticosteroid, prednisone.
Edrophonium	The corticosteroid, prednisone, may decrease the effect of the anticholinesterase, edrophonium.
Secobarbital	The barbiturate, secobarbital, may decrease the effect of the corticosteroid, prednisone.
Chlorotrianisene	The estrogenic agent, chlorotrianisene, may increase the effect of corticosteroid, prednisone.
Ethotoin	The enzyme inducer, ethotoin, may decrease the effect of the corticosteroid, prednisone.

Estropipate	The estrogenic agent, estropipate, may increase the effect of corticosteroid, prednisone.
Edrophonium	The corticosteroid, prednisone, may decrease the effect of the anticholinesterase, edrophonium.
Secobarbital	The barbiturate, secobarbital, may decrease the effect of the corticosteroid, prednisone.
Chlorotrianisene	The estrogenic agent, chlorotrianisene, may increase the effect of corticosteroid, prednisone.
Ethotoin	The enzyme inducer, ethotoin, may decrease the effect of the corticosteroid, prednisone.
Primidone	The barbiturate, primidone, may decrease the effect of the corticosteroid, prednisone.
Butalbital	The barbiturate, butalbital, may decrease the effect of the corticosteroid, prednisone.
Dicumarol	The corticosteroid, prednisone, alters the anticoagulant effect of dicumarol.
Quinidine barbiturate	The barbiturate, quinidine barbiturate, may decrease the effect of the corticosteroid, prednisone.
Diethylstilbestrol	The estrogenic agent, diethylstilbestrol, may increase the effect of corticosteroid, prednisone.
Trastuzumab	Trastuzumab may increase the risk of neutropenia and anemia. Monitor closely for signs and symptoms of adverse events.
Mestranol	The estrogenic agent, mestranol, may increase the effect of corticosteroid, prednisone.
Salicylate-sodium	The corticosteroid, prednisone, may decrease the effect of the salicylate, salicylate-sodium.
Acetylsalicylic acid	The corticosteroid, prednisone, may decrease the effect of the salicylate, acetylsalicylic acid.
Ambenonium	The corticosteroid, prednisone, may decrease the effect of the anticholinesterase, ambenonium.
Itraconazole	The imidazole, itraconazole, may increase the effect and toxicity of the corticosteroid, prednisone.
Warfarin	The corticosteroid, prednisone, alters the anticoagulant effect of warfarin.
Bismuth Subsalicylate	The corticosteroid, prednisone, may decrease the effect of the salicylate, bismuth subsalicylate.
Salsalate	The corticosteroid, prednisone, may decrease the effect of the salicylate, salsalate.
Butethal	The barbiturate, butethal, may decrease the effect of the corticosteroid, prednisone.
Magnesium salicylate	The corticosteroid, prednisolone, may decrease the effect of magnesium salicylate.
Midodrine	Increased arterial pressure
Talbutal	The barbiturate, talbutal, may decrease the effect of the corticosteroid, prednisone.
Ketoconazole	The imidazole, ketoconazole, may increase the effect and toxicity of the corticosteroid, prednisone.
Phenobarbital	The barbiturate, phenobarbital, may decrease the effect of the corticosteroid, prednisone.
Dihydroquinidine barbiturate	The barbiturate, dihydroquinidine barbiturate, may decrease the effect of the corticosteroid, prednisone.
Quinestrol	The estrogenic agent, quinestrol, may increase the effect of corticosteroid, prednisone.
Acenocoumarol	The corticosteroid, prednisone, alters the anticoagulant effect, acenocoumarol.
Pentobarbital	The barbiturate, pentobarbital, may decrease the effect of the corticosteroid, prednisone.
Ethinyl Estradiol	The estrogenic agent, ethinyl estradiol, may increase the effect of corticosteroid, prednisone.
Anisindione	The corticosteroid, prednisone, alters the anticoagulant effect of anisindione.
Amobarbital	The barbiturate, amobarbital, may decrease the effect of the corticosteroid, prednisone.
Methylphenobarbital	The barbiturate, methylphenobarbital, may decrease the effect of the corticosteroid, prednisone.
Estriol	The estrogenic agent, estriol, may increase the effect of corticosteroid, prednisone.
Clomifene	The estrogenic agent, clomifene, may increase the effect of corticosteroid, prednisone.
Neostigmine	The corticosteroid, prednisone, may decrease the effect of the anticholinesterase, neostigmine.
Trisalicylate-choline	The corticosteroid, prednisone, may decrease the effect of the salicylate, trisalicylate-choline.
Methohexital	The barbiturate, methohexital, may decrease the effect of the corticosteroid, prednisone.
Aprobarbital	The barbiturate, aprobarbital, may decrease the effect of the corticosteroid, prednisone.
Mephenytoin	The enzyme inducer, mephenytoin, may decrease the effect of the corticosteroid, prednisone.
Butabarbital	The barbiturate, butabarbital, may decrease the effect of the corticosteroid, prednisone.
Hexobarbital	The barbiturate, hexobarbital, may decrease the effect of the corticosteroid, prednisone.
Estrone	The estrogenic agent, estrone, may increase the effect of corticosteroid, prednisone.
Vecuronium	Vecuronium may increase the adverse neuromuscular effects of systemic corticosteroids, such as Prednisone. Monitor for increased muscle weakness and signs of polyneuropathies and myopathy.
Pyridostigmine	The corticosteroid, prednisone, may decrease the effect of the anticholinesterase, pyridostigmine.
Conjugated Estrogens	The estrogenic agent may increase the effect of corticosteroid, prednisone.
Tacrine	Tacrine and Prednisone may independently exacerbate muscle weakness in myasthenia gravis patients. Monitor for additive muscle weakness effects.
Fosphenytoin	The enzyme inducer, fosphenytoin, may decrease the effect of the corticosteroid, prednisone.
Estradiol	The estrogenic agent, estradiol, may increase the effect of corticosteroid, prednisone.
Rifampin	The enzyme inducer, rifampin, may decrease the effect of the corticosteroid, prednisone.
Phenytoin	The enzyme inducer, phenytoin, may decrease the effect of the corticosteroid, prednisone.
Heptabarbital	The barbiturate, heptabarbital, may decrease the effect of the corticosteroid, prednisone.

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Targets

Glucocorticoid receptor

Enzymes

Cytochrome P450 3A4

Cytochrome P450 2C19

Transporters

Multidrug resistance protein 1

Solute carrier organic anion transporter family member 1A2