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QuickView for Prednisolone (compound)

Name: Prednisolone
PubChem Compound ID: 11245343
Description: A glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states.
Molecular formula: C21H28O5
Molecular weight: 360.444 g/mol
Name: Prednisolone
Name (isomeric): DB00860
Drug Type: small molecule
Description: A glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states.
Predisolone Sodium Phosphate; Prednisolone Acetate; Prednisolonum [INN-Latin]; Methylprednisolone Acetate; Prednisolone Tebutate; Deltahydrocortisone; Prednisolona [INN-Spanish]; Prednisolone Sodium Phosphate; PRDL
Brand: Klismacort, Ultracortene H, Decortin H, Prednis, Ulacort, Nor-Pred T.B.A., Fernisolone, Delta-Cortef, Hydroretrocortine, Ocu-Pred Forte, Inflamase Mild, Key-Pred, Metacortandralone, Ak-Pred, Paracotol, Hydroretrocortin, I-Pred, Cotogesic, Pred Mild, Codelcortone, Donisolone, Delcortol, Delta F, Inflamase Forte, Econopred Plus, Di-Adreson F, Predalone 50, Predair, Erbacort, Orapred, Supercortisol, Hostacortin H, Predcor-25, Medrol Acetate, Hydeltra, Predonine, Ultra Pred, Prednelan, Fernisolone P, Precortancyl, Ultracortene-Hydrogen, Predonin, Ak-Tate, Decaprednil, Medrol, Cotolone, Nisolone, Hydrodeltalone, Hydeltra-Tba, Deltacortril, Flamasone, Depo-Medrol, Delta-Stab, Precortisyl, Predcor-Tba, Dydeltrone, Alphadrol, Ultracorten H, Dicortol, Predni-Dome, Dexa-Cortidelt Hostacortin H, Cortalone, Deltasolone, Meticortelone, Lentosone, Steran, Deltacortril Enteric, Precortalon, Solone, Predate Tba, Derpo Pd, Paracortol, Hydeltrone, Predniliderm, Ultracortene-H, Prenolone, Lite Pred, Deltisilone, Ophtho-Tate, Panafcortelone, Sterane, Articulose-50, Meti-Derm, Prelone, Rolisone, Predne-Dome, Eazolin D, M-Predrol, Predalone T.B.A., Hydrodeltisone, Scherisolon, Sterolone, Cordrol, Precortilon, Prednicen, Erbasona, Metreton, Ocu-Pred, Predcor-50, Econopred, Hydeltrasol, Predniretard, Estilsona, Co-Hydeltra, Pediapred, Deltacortenol, Pred Forte, Fernisolone-P, Predair A, Predair Forte, Predate-50
Brand name mixture:
Ak Cide Oph Soln(Prednisolone Acetate + Sulfacetamide Sodium), Blephamide Oph Ont(Prednisolone Acetate + Sulfacetamide Sodium), Blephamide Opht Suspension(Prednisolone Acetate + Sulfacetamide Sodium), Surolan Drops(Miconazole Nitrate + Polymyxin B Sulfate + Prednisolone Acetate), Dioptimyd Ointment(Prednisolone Acetate + Sulfacetamide Sodium), O...
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Category: Antineoplastic Agents, Hormonal, Adrenergic Agents, Antineoplastic Agents, Glucocorticoids, Anti-inflammatory Agents
CAS number: 50-24-8
Indication: For the treatment of primary or secondary adrenocortical insufficiency, such as congenital adrenal hyperplasia, thyroiditis. Also used to treat psoriatic arthritis, rheumatoid arthritis, ankylosing spondylitis, bursitis, acute gouty arthritis and epicondylitis. Also indicated for treatment of systemic lupus erythematosus, pemphigus and acute rhematic carditis. Can be used in the treatment of leukemias, lymphomas, thrombocytopenia purpura and autoimmune hemolytic anemia. Can be used to treat celiac disease, insulin resistance, ulcerative colitis and liver disorders.
Prednisolone is a synthetic glucocorticoid used as antiinflammatory or immunosuppressive agent. Prednisolone is indicated in the treatment of various conditions, including congenital adrenal hyperplasia, psoriatic arthritis, systemic lupus erythematosus, bullous dermatitis herpetiformis, seasonal or perennial allergic rhinitis, allergic corneal mar...
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Mechanism of Action:
Glucocorticoids such as Prednisolone can inhibit leukocyte infiltration at the site of inflammation, interfere with mediators of inflammatory response, and suppress humoral immune responses. The antiinflammatory actions of glucocorticoids are thought to involve phospholipase A2 inhibitory proteins, lipocortins, which control the biosynthesis of pot...
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Absorption: Readily absorbed by gastrointestinal tract, peak plasma concentration is reached 1-2 hours after administration.
Protein binding: Very high (>90%)
Biotransformation: Excreted in the urine as either free or glucoconjugate.
Half Life: 2-3 hours
Toxicity: LD50=500 mg/kg (oral, rat), short-term side effects include high blood glucose levels and fluid retention. Long term side effects include Cushing's syndrome, weight gain, osteoporosis, glaucoma, type II diabetes and adrenal suppression.
Affected organisms: Humans and other mammals
Food interaction:
Take with food to reduce gastric irritation.
Avoid alcohol. Avoid caffeine.
Drug interaction:
Dihydroquinidine barbiturateThe barbiturate, dihydroquinidine barbiturate, may decrease the effect of the corticosteroid, prednisolone.
EstradiolThe estrogenic agent, estradiol, may increase the effect of the corticosteroid, prednisolone.
VecuroniumVecuronium may increase the adverse neuromuscular effects of systemic corticosteroids, such as Prednisolone. Monitor for increased muscle weakness and signs of polyneuropathies and myopathy.
HexobarbitalThe barbiturate, hexobarbital, may decrease the effect of the corticosteroid, prednisolone.
SalsalateThe corticosteroid, prednisolone, may decrease the effect of the salicylate, salsalate.
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