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QuickView for Ticarcillin (compound)

Summary
General Info

PubChem

PubChem Compound 104961

PubChem Compound 104961

Name:	Ticarcillin
PubChem Compound ID:	104961
Description:	An antibiotic derived from penicillin similar to CARBENICILLIN in action.
Molecular formula:	C₁₅H₁₆N₂O₆S₂
Molecular weight:	384.429 g/mol
Synonyms:	34787-01-4; Ticarcillin; C07139

DrugBank

Identification

Name:	Ticarcillin
Name (isomeric):	DB01607
Drug Type:	small molecule
Description:	An antibiotic derived from penicillin similar to CARBENICILLIN in action.
Synonyms:	Ticarcilina [inn-spanish]; Ticarcillin supplement; Ticarcillinum [inn-latin]; Ticarcilline [inn-french]
Brand name mixture:	Timentin(Ticarcillin + Clavulanate)
Category:	Anti-Bacterial Agents, Penicillins
CAS number:	34787-01-4

Pharmacology

Indication:	For the treatment of bacterial infections.
Pharmacology:	Ticarcillin is a semisynthetic antibiotic with a broad spectrum of bactericidal activity against many gram-positive and gram-negative aerobic and anaerobic bacteria. Ticarcillin is, however, susceptible to degradation by ß-lactamases, and therefore, the spectrum of activity does not normally include organisms which produce these enzymes.
Mechanism of Action:	Ticarcillin's antibiotic properties arise from its ability to prevent cross-linking of peptidoglycan during cell wall synthesis when the bacteria tries to divide, causing death.
Protein binding:	45%
Half Life:	1.1 hours
Toxicity:	As with other penicillins, neurotoxic reactions may arise when very high doses of ticarcillin are administered, especially in patients with impaired renal function.
Affected organisms:	Enteric bacteria and other eubacteria

Interactions

Drug interaction:

Ethinyl Estradiol	This anti-infectious agent could decrease the effect of the oral contraceptive
Fusidic Acid	Fusidic acid may reduce the effect of Ticarcillin by inhibiting bacterial growth. Ticarcillin exerts its effects on actively growing bacteria. To achieve synergism, Ticarcillin should be administered at least 2 hours prior to using Fusidic acid.
Streptomycin	Ticarcillin may reduce the serum concentration of Streptomycin. Ticarcillin may inactivate Streptomycin in vitro and the two agents should not be administered simultaneously through the same IV line.
Demeclocycline	Demeclocycline may reduce the effect of Ticarcillin by inhibiting bacterial growth. Ticarcillin exerts its effects on actively growing bacteria. To achieve synergism, Ticarcillin should be administered at least 2 hours prior to using Demeclocycline.
Amikacin	Ticarcillin may reduce the serum concentration of Amikacin. Ticarcillin may inactivate Amikacin in vitro and the two agents should not be administered simultaneously through the same IV line.

Ethinyl Estradiol	This anti-infectious agent could decrease the effect of the oral contraceptive
Fusidic Acid	Fusidic acid may reduce the effect of Ticarcillin by inhibiting bacterial growth. Ticarcillin exerts its effects on actively growing bacteria. To achieve synergism, Ticarcillin should be administered at least 2 hours prior to using Fusidic acid.
Streptomycin	Ticarcillin may reduce the serum concentration of Streptomycin. Ticarcillin may inactivate Streptomycin in vitro and the two agents should not be administered simultaneously through the same IV line.
Demeclocycline	Demeclocycline may reduce the effect of Ticarcillin by inhibiting bacterial growth. Ticarcillin exerts its effects on actively growing bacteria. To achieve synergism, Ticarcillin should be administered at least 2 hours prior to using Demeclocycline.
Amikacin	Ticarcillin may reduce the serum concentration of Amikacin. Ticarcillin may inactivate Amikacin in vitro and the two agents should not be administered simultaneously through the same IV line.
Oxytetracycline	Oxytetracycline may reduce the effect of Ticarcillin by inhibiting bacterial growth. Ticarcillin exerts its effects on actively growing bacteria. To achieve synergism, Ticarcillin should be administered at least 2 hours prior to using Oxytetracycline.
Methotrexate	The penicillin increases the effect and toxicity of methotrexate
Minocycline	Minocycline may reduce the effect of Ticarcillin by inhibiting bacterial growth. Ticarcillin exerts its effects on actively growing bacteria. To achieve synergism, Ticarcillin should be administered at least 2 hours prior to using Minocycline.
Neomycin	Ticarcillin may reduce the serum concentration of Neomycin. Ticarcillin may inactivate Neomycin in vitro and the two agents should not be administered simultaneously through the same IV line.
Tobramycin	Ticarcillin may reduce the serum concentration of Tobramycin. Ticarcillin may inactivate Tobramycin in vitro and the two agents should not be administered simultaneously through the same IV line.
Doxycycline	Doxycycline may reduce the effect of Ticarcillin by inhibiting bacterial growth. Ticarcillin exerts its effects on actively growing bacteria. To achieve synergism, Ticarcillin should be administered at least 2 hours prior to using Doxycycline.
Gentamicin	Ticarcillin may reduce the serum concentration of Gentamicin. Ticarcillin may inactivate Gentamicin in vitro and the two agents should not be administered simultaneously through the same IV line.
Kanamycin	Ticarcillin may reduce the serum concentration of Kanamycin. Ticarcillin may inactivate Kanamycin in vitro and the two agents should not be administered simultaneously through the same IV line.
Tetracycline	Tetracycline may reduce the effect of Ticarcillin by inhibiting bacterial growth. Ticarcillin exerts its effects on actively growing bacteria. To achieve synergism, Ticarcillin should be administered at least 2 hours prior to using Tetracycline.

Targets

Penicillin binding protein 2a