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PubChem
| Name: | Methoxamine |
|---|---|
| PubChem Compound ID: | 6081 |
| Description: | An alpha-1 adrenergic agonist that causes prolonged peripheral VASOCONSTRICTION. |
| Molecular formula: | C11H18ClNO3 |
| Molecular weight: | 247.718 g/mol |
| Synonyms: |
DL-2-Amino-1-(2,5-dimethoxyphenyl)propanol hydrochloride; 2-Amino-1-(2,5-dimethoxyphenyl)-1-propanol hydrochloride; Vasoxyl hydrochloride; Benzenemethanol, alpha-(1-aminoethyl)-2,5-dimethoxy-, hydrochloride; D01020; Methoxamine hydrochloride (JAN); (+-)-alpha-(1-Aminoethyl)-2,5-dimethoxybenzyl alcohol hydrochloride; EINECS 200-499-7; SMR000058479; 390-28-3.
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DrugBank
Identification
| Name: | Methoxamine |
|---|---|
| Name (isomeric): | DB00723 |
| Drug Type: | small molecule |
| Description: | An alpha-1 adrenergic agonist that causes prolonged peripheral VASOCONSTRICTION. |
| Brand: | Methoxamedrine, Vasoxyl, Metoxamina [INN-Spanish], Methoxaminum [INN-Latin], Vasoxine, Methoxamin, Pseudomethoxamine, Metossamina [DCIT] |
| Category: | Adrenergic alpha-Agonists, Sympathomimetics, Vasoconstrictor Agents |
| CAS number: | 390-28-3 |
Pharmacology
| Indication: | Indicated for the treatment and management of hypotension. |
|---|---|
| Pharmacology: |
Methoxamine is a potent sympathomimetic amine that increases both systolic and diastolic blood pressure. Methoxamine is indicated for prevention and treatment of the acute hypotensive state occurring with spinal anesthesia. It is also indicated as adjunctive treatment of hypotension due to hemorrhage, reactions to medications, surgical complication...
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| Mechanism of Action: | Methoxamine acts through peripheral vasoconstriction by acting as a pure alpha-1 adrenergic receptor agonist, consequently increasing systemic blood pressure (both systolic and diastolic). |
| Protein binding: | Low |
| Affected organisms: | Humans and other mammals |
Interactions
| Drug interaction: |
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Targets
