QuickView for Guanethidine (compound)

NSC29863; Octadin; CAS-60-02-6; Guanetidina [INN-Spanish]; Sanotensin; Guanidine, N-[2-(hexahydro-1(2H)-azocinyl)ethyl]-;; AIDS-155922; Octatensine; KBio2_006453; EINECS 200-241-3.
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NSC29863; Octadin; CAS-60-02-6; Guanetidina [INN-Spanish]; Sanotensin; Guanidine, N-[2-(hexahydro-1(2H)-azocinyl)ethyl]-;; AIDS-155922; Octatensine; KBio2_006453; EINECS 200-241-3; Su 5864 sulfate (1:1); 55-65-2; Octadine; DivK1c_000539; Octatensin; Guanidine, [2-(hexahydro-1(2H)-azocinyl)ethyl]-; Isobarin; 2-(1-N,N-Heptamethyleneimino)ethylguanidine; KBio3_001312; Azocine, 1-((2-(aminoiminomethyl)amino)ethyl)octahydro-; Dopom; NINDS_000539; Oktadin; Spectrum4_000568; NCGC00016272-01; Oktatenzin; Guanethidine; Eutensol; Prestwick1_000317; .Beta.-1-Azacyclooctylethylguanidine; AIDS155922; Heptamethylenimine, 1-(2-guanidinoethyl)-; N-(2-Perhydroazocin-1-ylethyl)guanidine; KBio1_000539; Guanethidine sulfate; HSDB 3092; Spectrum2_001103; KBio2_003885; (2-(Octahydro-1-azocinyl)ethyl)guanidine; 2-(1'-Azacyclooctyl)ethylguanidine; 60-02-6; Guanetidin sulfate; Spectrum_000837; C07036; KBioGR_000976; Guanethidinum [INN-Latin]; Dopam; Iporal; KBio2_001317; Spectrum3_000446; KBioSS_001317; Abapresin; Ismelin sulfate; Azocine, 1-(2-guanidinoethyl)octahydro-; Oktatensin; 645-43-2; Ismelin; SPBio_001206; Guanidine, (2-(hexahydro-1(2H)-azocinyl)ethyl)-; Prestwick0_000317; SPBio_002533
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Guanethidine Sulphae; Guanethidine Monosulfate

High blood pressure can cause the heart and arteries to not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled. Guane...
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High blood pressure can cause the heart and arteries to not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled. Guanethidine works by decreasing the heart rate and relaxing the blood vessels so that blood can flow more easily through the body, thereby reducing these risks. It is a postganglionic sympathetic nerve terminal blocker that prevents the release of norepinephrine from nerve terminals.
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Guanethidine acts at the sympathetic neuroeffector junction by inhibiting or interfering with the release and/or distribution of norepinephrine, rather than acting at the effector cell by inhibiting the association of norepinephrine with its receptors. It is taken up by norepinephrine transporters. It becomes concentrated in NE transmitter vesicles...
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Guanethidine acts at the sympathetic neuroeffector junction by inhibiting or interfering with the release and/or distribution of norepinephrine, rather than acting at the effector cell by inhibiting the association of norepinephrine with its receptors. It is taken up by norepinephrine transporters. It becomes concentrated in NE transmitter vesicles, replacing NE in these vesicles. This leads to a gradual depletion of NE stores in the nerve endings. Once inside the terminal it blocks the release of noradrenaline in response to arrival of an action potential. In contrast to ganglionic blocking agents, Guanethidine suppresses equally the responses mediated by alpha-and beta-adrenergic receptors but does not produce parasympathetic blockade. Since sympathetic blockade results in modest decreases in peripheral resistance and cardiac output, Guanethidine lowers blood pressure in the supine position. It further reduces blood pressure by decreasing the degree of vasoconstriction that normally results from reflex sympathetic nervous activity upon assumption of the upright posture, thus reducing venous return and cardiac output more.
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