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PubChem
| Name: | Ampicillin |
|---|---|
| PubChem Compound ID: | 11840918 |
| Description: | Semi-synthetic derivative of penicillin that functions as an orally active broad-spectrum antibiotic. |
| Molecular formula: | C16H21N3O4S |
| Molecular weight: | 351.422 g/mol |
| Synonyms: |
6-[D(-)-ALPHA-AMINOPHENYLLACETAMIDO]PENICILLANIC ACID; Ampicillin; D(-)-ALPHA-AMINOBENZYLPENICILLIN; (2S,5R,6R)-6-{[(2R)-2-AMINO-2-PHENYLETHANOYL]AMINO}-3,3-DIMETHYL-7-OXO-4-THIA-1-AZABICYCLO[3.2.0]HEPTANE-2-CARBOXYLIC ACID; AIC
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DrugBank
Identification
| Name: | Ampicillin |
|---|---|
| Name (isomeric): | DB00415 |
| Drug Type: | small molecule |
| Description: | Semi-synthetic derivative of penicillin that functions as an orally active broad-spectrum antibiotic. |
| Synonyms: |
Ampicillin Acid; Ampicillin Base; Ampicilline; Ampicilina [INN-Spanish]; Ampicillin Trihydrate; Ampicillinum [INN-Latin]; Anhydrous Ampicillin; Aminobenzylpenicillin; D-Ampicillin; Ampicillin Sodium.
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| Brand: | Ampi-Co, Ampiscel, Penbrock, Ro-Ampen, Principen, Pen A, Deripen, Morepen, Amfipen V, Roscillin, Totacillin, Amcill, Ultrabron, Ampivax, Omnipen-N, Pfizerpen A, AB-PC, Omnipen, Servicillin, Principen '250', Texcillin, Viccillin, Pen a Oral, Ampisyn, Adobacillin, Viccillin S, Bonapicillin, Ampy-Penyl, Lifeampil, Ampimed, Amipenix S, Penbritin-S, Wypicil, Vampen, Guicitrine, Sk-Ampicillin, Amblosin, Cimex, Amplipenyl, Semicillin R, Grampenil, Totapen, Racenacillin, Copharcilin, Binotal, Duphacillin, Britacil, Amplisom, Divercillin, Ampikel, Pen Ampil, Penicline, Polycillin-N, Ampen, Ampicil, Ampifarm, Geocillin, Amfipen, Ampicin, Totacillin-N, Penbritin, Ultrabion, Trifacilina, Alpen, Norobrittin, Polycillin, Ampi-Tab, Austrapen, Ab-Pc Sol, Ampivet, Semicillin, Amplital, Ampi-Bol, Olin Kid, Delcillin, Principen '500', Qidamp, Tokiocillin, Ampipenin, Pensyn, D-Cillin, Pentrexyl, Pentrexl, Guicitrina, Penbritin Paediatric, Amplacilina, Supen, Ampichel, Totalciclina, Penbristol, Ampipenin, Nt3, Tolomol, Sumipanto, Principen '125', Spectrobid, Nuvapen, Pfizerpen-A, Ponecil, Doktacillin, Rosampline, Orbicilina, Campicillin, Synpenin, Acillin, Pentrex, Princillin, BRL, Ampicillin A, Penbritin Syrup, Amplin, Ampi, Novo-Ampicillin, Penimic |
| Brand name mixture: | Pro Biosan Kit(Ampicillin + Probenecid), Synergistin Injectable Suspension(Ampicillin + Sulbactam (Sulbactam Benzathine)) |
| Category: | Anti-Bacterial Agents, Penicillins |
| CAS number: | 69-53-4 |
Pharmacology
| Indication: | For treatment of infection (Respiratory, GI, UTI and meningitis) due to E. coli, P. mirabilis, enterococci, Shigella, S. typhosa and other Salmonella, nonpenicillinase-producing N. gononhoeae, H. influenzae, staphylococci, streptococci including streptoc |
|---|---|
| Pharmacology: |
Ampicillin is a penicillin beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually gram-positive, organisms. The name "penicillin" can either refer to several variants of penicillin available, or to the group of antibiotics derived from the penicillins. Ampicillin has in vitro activity against gram...
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| Mechanism of Action: | By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, Ampicillin inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that Ampicillin interferes with an autolysin inhibitor. |
| Route of elimination: | Ampicillin is excreted largely unchanged in the urine. |
| Affected organisms: | Enteric bacteria and other eubacteria |
Interactions
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